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Link to original content: http://www.informatics.jax.org/marker/MGI:101875
Thpo MGI Mouse Gene Detail - MGI:101875 - thrombopoietin
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Thpo Gene Detail
Summary
  • Symbol
    Thpo
  • Name
    thrombopoietin
  • Synonyms
    Mpllg, myeloproliferative leukemia virus oncogene ligand, TPO, TPO-1, TPO-2, TPO-3, TPO-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:101875
    NCBI Gene: 21832
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20543204-20553261 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.51 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101875
 protein coding gene Chr16:20543204-20553261 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022655
 protein coding gene Chr16:18074997-18080575 (-)
A/J MGP_AJ_G0022617
 protein coding gene Chr16:17202469-17207784 (-)
AKR/J MGP_AKRJ_G0022592
 protein coding gene Chr16:17849718-17855034 (-)
BALB/cJ MGP_BALBcJ_G0022621
 protein coding gene Chr16:17358521-17363849 (-)
C3H/HeJ MGP_C3HHeJ_G0022386
 protein coding gene Chr16:18023333-18028661 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023072
 protein coding gene Chr16:18432451-18437779 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020590
 protein coding gene Chr16:17886238-17895593 (-)
CAST/EiJ MGP_CASTEiJ_G0021916
 protein coding gene Chr16:17997877-18007127 (-)
CBA/J MGP_CBAJ_G0022358
 protein coding gene Chr16:19183258-19188574 (-)
DBA/2J MGP_DBA2J_G0022490
 protein coding gene Chr16:17129537-17134865 (-)
FVB/NJ MGP_FVBNJ_G0022465
 protein coding gene Chr16:17171189-17176539 (-)
LP/J MGP_LPJ_G0022557
 protein coding gene Chr16:17799059-17812022 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022485
 protein coding gene Chr16:18849461-18855037 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023083
 protein coding gene Chr16:17823442-17829020 (-)
PWK/PhJ MGP_PWKPhJ_G0021657
 protein coding gene Chr16:17399405-17409271 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021487
 protein coding gene Chr16:17625839-17635312 (-)
WSB/EiJ MGP_WSBEiJ_G0021960
 protein coding gene Chr16:17817278-17822841 (-)



Homology
more
  • Human Ortholog
    THPO, thrombopoietin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THPO, thrombopoietin
  • Synonyms
    CAMT2, MGDF, MKCSF, ML, MPLLG, THC9, THCYT1, TPO
  • Links
    NCBI Gene ID: 7066
    neXtProt AC: NX_P40225
    UniProt: P40225

  • Chr Location
    Xq27.1
Human Diseases
more
  • Diseases
    4 with human THPO associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations at this locus are unable to produce normal amounts of megakaryocytes and platelets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    59
  • cDNA Data
    14
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21832 NCBI Gene Model | MGI Sequence Detail 10058 C57BL/6J ±  kb
    transcript NM_009379 RefSeq | MGI Sequence Detail 2416 ZRU/MplStud  
    polypeptide P40226 UniProt | EBI | MGI Sequence Detail 356 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 14
      Primer pair 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16629, MGD-MRK-18701
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 14
      Gene Ontology 8
      Phenotypes 53
    • Earliest
      J:18896 Lok S, et al., Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo [see comments]. Nature. 1994 Jun 16;369(6481):565-8
    • Latest
      J:351065 Sun Y, et al., Notch1 regulates hepatic thrombopoietin production. Blood. 2024 Jun 27;143(26):2778-2790
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory