- Played a suicidal mental patient in the music video for the Melissa Etheridge song "Come to My Window". Lewis' erratic behavior frightened the director to the point where he yelled "Cut!" several times for fear that Lewis had truly suffered a mental/emotional breakdown.
- Legally emancipated from her parents at age 14.
- Arrested for being underage in an underground dance club at age 16. The arresting officer, who recognized her dad when he picked her up at the station, gave Juliette her mug shot (the charges were dropped), which now hangs, poster-size, in her home (this picture can be seen at Fan Page)
- Drove without driver's license until she was 21. She owned a car bought under a friend's name and had been driving illegally since age 15. Eventually got a license after she got caught not stopping at a stop sign.
- Dropped out of high school just three weeks after starting.
- Had a four-year relationship with Brad Pitt. She was 16 years old, while Pitt was 26 when their relationship began in 1989. They met on the set of the TV movie Too Young to Die? (1990), in which they played a couple, and worked together again in Kalifornia (1993). They lived together and the relationship ended in 1993.
- Fronts a rock band called "Juliette and the Licks" which is touring on Van's Warped Tour in 2004.
- Auditioned for the role of Lydia Deetz which was played by Winona Ryder in Beetlejuice (1988).
- Her song from Natural Born Killers (1994) was used in another song, "Bad Brother" by The Infidels.
- Turned down the role of Mia Thermopolis that eventually went to Anne Hathaway in The Princess Diaries (2001).
- Father almost named her Snow Lake.
- Friend of Alanis Morissette.
- Although she is now divorced, she remains good friends with her ex-husband, Stephen Berra.
- Posed for a portrait in US Magazine, by Peggy Sirota, which featured nothing but an extreme close-up of the soles of her bare feet.
- Performed in Finnish rock music festival Ruisrock. (July 2007)
- Chosen by Empire magazine as one of the 100 Sexiest Stars in film history (#75). (1995)
- Sister-in-law of Ethan Suplee. He is married to her sister Brandy Lewis.
- Ranked #7 on Tropopkin's Top 25 Most Intriguing People [Issue #100]
- She was introduced to her future husband Stephen Berra by her younger sister Brandy Lewis.
- London, England, in rehearsal to star as "May" (alongside Martin Henderson as "Eddie") in the upcoming revival of Sam Shepard's "Fool for Love", which opens at the Apollo Theatre on 13th June. (May 2006)
- She was in Buenos Aires, Argentina only for one day (October 26), where she acted with her band The Licks in a private event. (October 2007)
- Starred with both the Quaid brothers,Randy in "National Lampoon's Christmas Vacation" (1989) and Dennis in "Cold Creek Manor" (2003).
- After she was emancipated, she briefly resided with Karen Black, who was a friend of her father.
- Is a member of the Church of Scientology.
- As of 2018, has never appeared in a film nominated for the Best Picture Oscar.
- Juliette Lewis bears a striking resemblance to the late actress Gina Mastrogiacomo.
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