depletion (n.)

"empty, reduce, or exhaust by drawing away," 1807, originally in medicine (of blood-letting, purgatives), back-formation from depletion, which is from Latin deplere "to empty," literally "to un-fill," from de "off, away" (see de-) + plere "to fill" (from PIE root *pele- (1) "to fill"). General sense by 1859. Related: Depleted; depleting.

active word-forming element in English and in many verbs inherited from French and Latin, from Latin de "down, down from, from, off; concerning" (see de), also used as a prefix in Latin, usually meaning "down, off, away, from among, down from," but also "down to the bottom, totally" hence "completely" (intensive or completive), which is its sense in many English words.

As a Latin prefix it also had the function of undoing or reversing a verb's action, and hence it came to be used as a pure privative — "not, do the opposite of, undo" — which is its primary function as a living prefix in English, as in defrost (1895), defuse (1943), de-escalate (1964), etc. In some cases, a reduced form of dis-.

*pelə-, Proto-Indo-European root meaning "to fill," with derivatives referring to abundance and multitude.

It forms all or part of: accomplish; complete; compliment; comply; depletion; expletive; fele; fill; folk; full (adj.); gefilte fish; hoi polloi; implement; manipulation; nonplus; plebe; plebeian; plebiscite; pleiotropy; Pleistocene; plenary; plenitude; plenty; plenum; plenipotentiary; pleo-; pleonasm; plethora; Pliocene; pluperfect; plural; pluri-; plus; Pollux; poly-; polyamorous; polyandrous; polyclinic; polydactyl; polydipsia; Polydorus; polyethylene; polyglot; polygon; polygraph; polygyny; polyhedron; polyhistor; polymath; polymer; polymorphous; Polynesia; polyp; Polyphemus; polyphony; polysemy; polysyllabic; polytheism; replenish; replete; supply; surplus; volkslied.

It is the hypothetical source of/evidence for its existence is provided by: Sanskrit purvi "much," prayah "mostly;" Avestan perena-, Old Persian paru "much;" Greek polys "much, many," plethos "people, multitude, great number," ploutos "wealth;" Latin plus "more," plenus "full;" Lithuanian pilus "full, abundant;" Old Church Slavonic plunu; Gothic filu "much," Old Norse fjöl-, Old English fela, feola "much, many;" Old English folgian; Old Irish lan, Welsh llawn "full;" Old Irish il, Welsh elu "much."