Testosterone Congeners

Name
Testosterone Congeners
Accession Number
DBCAT001014  (DBCAT001357, DBCAT003190)
Description

Steroidal compounds related to TESTOSTERONE, the major mammalian male sex hormone. Testosterone congeners include important testosterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with androgenic activities.

ATC Classification
Drugs
DrugDrug Description
TestosteroneA hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause.
Nandrolone phenpropionateFor the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the...
TrilostaneUsed in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
Testosterone propionateA slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.
19-norandrostenedioneThe claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated.
5-androstenedione5-androstenedione is a prohormone of testosterone. In the United States, the Controlled Substance Act is inclusive to anabolic steroids and their precursors. Thus 5-androstenedione is a controlled substance, and its...
BolasteroneNot Available
1-Testosterone1-Testosterone is an anabolic steroid that differs from testosterone by having a 1,2-double bond instead of 4,5-double bond in its A ring.
4-Hydroxytestosterone4-Hydroxytestosterone is testosterone substituted with a hydroxy group on the fourth carbon atom. It is an anabolic steroid with no therapeutic indications, which is prohibited from use in sports by...
ClostebolNot Available
AndrostenediolAndrostenediol is an intermediate in testosterone biosynthesis, found in the testis or the adrenal glands. Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), is converted...
AndrostenedioneA delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as...
BoldenoneBoldenone is an anabolic steroid developed for veterinary use, mostly for treatment of horses. It is not indicated for use in humans in the US and is only available through...
BolandiolNot Available
CalusteroneAn anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was...
PrasteroneA steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy.
StanoloneA potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure...
16-BromoepiandrosteroneInvestigated for use/treatment in cystic fibrosis, HIV infection, hepatitis (viral, B), and malaria.
Prasterone sulfateInvestigated for use/treatment in asthma and burns and burn infections.
TrestoloneInvestigated for use/treatment in contraception and male hormonal deficiencies/abnormalities.
FluasteroneInvestigated for use/treatment in psoriasis and psoriatic disorders, hyperlipidemia, metabolic disease, cancer/tumors (unspecified), and obesity.
MethyltestosteroneA synthetic anabolic steroid used for the replacement therapy in conditions associated with testosterone deficiencies in males, such as hypogonadism, and treatment of advancing inoperable metastatic breast cancer in females.
Testosterone succinateNot Available
Nandrolone decanoateAn anabolic steroid indicated for the management of the anemia of renal insufficiency by increasing hemoglobin and red cell mass.
FormestaneFor the treatment of estrogen-receptor positive breast cancer in post-menopausal women.
DienogestAn oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol.
MiboleroneMibolerone is a potent anabolic steroid which is both higher affinity and more selective for the androgen receptor than metribolone.
AtamestaneAtamestane has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasms, Hormone-Dependent.
NandroloneAn anabolic steroid indicated to increase bone density and muscle mass in patients with osteoporosis.
MesteroloneAn anabolic steroid indicated in the treatment of low testosterone, hypogonadism, oligozoospermia, and Leydig cell failure.
MetenoloneAn anabolic steroid indicated in the treatment and prevention of muscle wasting due to diseases, drug treatments, or other catabolic processes.
Testosterone cypionateAn androgen used to treat low or absent testosterone.
Testosterone enanthateAn androgen used to treat low or absent testosterone.
Testosterone undecanoateAn androgen indicated for testosterone replacement therapy in adult males with primary hypogonadism and hypogonadotropic hypogonadism.
Testosterone enantate benzilic acid hydrazoneNot Annotated
Trestolone acetateTrestolone acetate is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is an androgen ester – specifically, the C17 acetate...
EpitestosteroneEpitestosterone is the 17-alpha isomer of testosterone, derived from pregnenolone via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone...
Clostebol acetateA steroid combined with neomycin in topical formulations for the treatment of minor skin wounds.
Testosterone decanoateA steroid indicated for testosterone replacement therapy in sterilization, missing testicle, hypopituitarism, and osteoporosis.
Testosterone isocaproateA steroid indicated for testosterone replacement therapy in sterilization, missing testicle, hypopituitarism, and osteoporosis.
Testosterone phenylpropionateA steroid indicated for testosterone replacement therapy in sterilization, missing testicle, hypopituitarism, and osteoporosis.
Prasterone enantateAn estrogen indicated for hormone replacement therapy in postmenopausal women.
5alpha-androstane-3beta,17alpha-diol5alpha-androstane-3beta,17alpha-diol is the unspecified form of the steroid, normally a major metabolite of testosterone with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.
MethylhexaneamineNot Annotated
Drugs & Drug Targets
DrugTargetType
TestosteroneAndrogen receptortarget
TestosteroneCytochrome P450 3A4enzyme
TestosteroneAromataseenzyme
TestosteroneAmine oxidase [flavin-containing] Aenzyme
TestosteroneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
TestosteroneAlbumincarrier
TestosteroneSex hormone-binding globulincarrier
TestosteroneCytochrome P450 3A5enzyme
TestosteroneCytochrome P450 3A7enzyme
TestosteroneOrganic anion transporter 3transporter
TestosteroneSolute carrier family 22 member 7transporter
TestosteroneHepatic sodium/bile acid cotransportertransporter
TestosteroneBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
TestosteroneCytochrome P450 1A1enzyme
TestosteroneCytochrome P450 1B1enzyme
TestosteroneCytochrome P450 2A13enzyme
TestosteroneCytochrome P450 2B6enzyme
TestosteroneCytochrome P450 2C19enzyme
TestosteroneCytochrome P450 2C8enzyme
TestosteroneCytochrome P450 2C9enzyme
TestosteroneCytochrome P450 3A43enzyme
TestosteroneEstrogen receptortarget
TestosteroneMineralocorticoid receptortarget
TestosteroneSolute carrier organic anion transporter family member 1B3transporter
Nandrolone phenpropionateAndrogen receptortarget
Trilostane3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
Trilostane3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2target
TrilostaneEstrogen receptor betatarget
TrilostaneEstrogen receptortarget
Testosterone propionateAndrogen receptortarget
Testosterone propionateCatechol O-methyltransferaseenzyme
Testosterone propionateUDP-glucuronosyltransferase 1A1enzyme
Testosterone propionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone propionateCytochrome P450 3A4enzyme
Testosterone propionateATP-dependent translocase ABCB1transporter
Testosterone propionateSex hormone-binding globulincarrier
Testosterone propionateAlbumincarrier
5-androstenedioneCytochrome P450 3A4enzyme
1-TestosteroneAndrogen receptortarget
AndrostenediolEstrogen receptortarget
AndrostenediolEstrogen receptor betatarget
AndrostenedioneAldo-keto reductase family 1 member C3target
Androstenedione17-beta-hydroxysteroid dehydrogenase type 1target
Androstenedione6-deoxyerythronolide B hydroxylasetarget
Androstenedione3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
AndrostenedioneCytochrome P450 3A4enzyme
AndrostenedioneAldo-keto reductase family 1 member C3enzyme
AndrostenedioneAromatasetarget
BoldenoneAndrogen receptortarget
CalusteroneAndrogen receptortarget
PrasteroneCytochrome P450 3A7enzyme
PrasteronePeroxisome proliferator-activated receptor alphatarget
PrasteroneEstrogen receptortarget
PrasteroneSigma non-opioid intracellular receptor 1target
PrasteroneEstrogen receptor betatarget
PrasteroneNuclear receptor subfamily 1 group I member 2target
PrasteroneNuclear receptor subfamily 1 group I member 3target
PrasteroneGABA(A) Receptortarget
PrasteroneNMDA receptortarget
PrasteroneAndrogen receptortarget
Prasterone17-beta-hydroxysteroid dehydrogenase type 1enzyme
PrasteroneSulfotransferase 2A1enzyme
PrasteroneSulfotransferase 2B1enzyme
Prasterone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1enzyme
PrasteroneCholesterol oxidaseenzyme
PrasteroneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
PrasteroneSolute carrier organic anion transporter family member 1B3transporter
PrasteroneSolute carrier organic anion transporter family member 2B1transporter
PrasteroneSolute carrier organic anion transporter family member 1B1transporter
PrasteroneSolute carrier organic anion transporter family member 1A2transporter
PrasteroneMultidrug resistance-associated protein 1transporter
PrasteroneBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
PrasteroneATP-binding cassette sub-family C member 4transporter
PrasteroneGlucose-6-phosphate 1-dehydrogenasetarget
StanoloneSex hormone-binding globulincarrier
StanoloneAndrogen receptortarget
Stanolone17-beta-hydroxysteroid dehydrogenase type 1target
StanoloneATP-dependent translocase ABCB1transporter
StanoloneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
StanoloneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
StanoloneAromataseenzyme
StanoloneEstrogen receptortarget
StanoloneMineralocorticoid receptortarget
StanoloneAldo-keto reductase family 1 member C3enzyme
16-BromoepiandrosteroneGlucose-6-phosphate 1-dehydrogenasetarget
16-BromoepiandrosteroneAndrogen receptortarget
Prasterone sulfateAromataseenzyme
Prasterone sulfateCytochrome P450 3A7enzyme
Prasterone sulfateProstaglandin G/H synthase 2enzyme
Prasterone sulfateOrganic anion transporter 3transporter
Prasterone sulfateSolute carrier organic anion transporter family member 1A2transporter
Prasterone sulfateSolute carrier organic anion transporter family member 1B1transporter
Prasterone sulfateSolute carrier organic anion transporter family member 1B3transporter
Prasterone sulfateSolute carrier organic anion transporter family member 2B1transporter
Prasterone sulfateSodium-dependent organic anion transportertransporter
Prasterone sulfateBile salt export pumptransporter
MethyltestosteroneCytochrome P450 2B6enzyme
MethyltestosteroneCytochrome P450 3A4enzyme
MethyltestosteroneAndrogen receptortarget
MethyltestosteroneSolute carrier organic anion transporter family member 1A2transporter
MethyltestosteroneOrganic anion transporter 3transporter
MethyltestosteroneAlbumincarrier
MethyltestosteroneSex hormone-binding globulincarrier
MethyltestosteroneEstrogen receptortarget
MethyltestosteroneAromataseenzyme
Testosterone succinateNeocarzinostatintarget
Nandrolone decanoateAndrogen receptortarget
Nandrolone decanoateAromataseenzyme
Nandrolone decanoateAmine oxidase [flavin-containing] Benzyme
Nandrolone decanoateAmine oxidase [flavin-containing] Aenzyme
Nandrolone decanoateProtein c-Fostarget
Nandrolone decanoate5-hydroxytryptamine 2 receptortarget
Nandrolone decanoate5-hydroxytryptamine receptor 1Btarget
Nandrolone decanoateInsulin-like growth factor 1 receptortarget
Nandrolone decanoateDopamine receptortarget
Nandrolone decanoateUDP-glucuronosyltransferase 2B7enzyme
Nandrolone decanoateUDP-glucuronosyltransferase 1A4enzyme
Nandrolone decanoateUDP-glucuronosyltransferase 2B4enzyme
Nandrolone decanoateUDP-glucuronosyltransferase 1A3enzyme
Nandrolone decanoateUDP-glucuronosyltransferase 1A1enzyme
Nandrolone decanoateUDP-glucuronosyltransferase 1A10enzyme
Nandrolone decanoateSex hormone-binding globulincarrier
FormestaneCytochrome P450 3A4enzyme
FormestaneAromatasetarget
DienogestCytochrome P450 3A4enzyme
DienogestProgesterone receptortarget
DienogestAndrogen receptortarget
MiboleroneAndrogen receptortarget
NandroloneAndrogen receptortarget
Testosterone cypionateAndrogen receptortarget
Testosterone cypionateCytochrome P450 3A4enzyme
Testosterone cypionateAmine oxidase [flavin-containing] Aenzyme
Testosterone cypionateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
Testosterone cypionateAlbumincarrier
Testosterone cypionateSex hormone-binding globulincarrier
Testosterone cypionateCytochrome P450 3A5enzyme
Testosterone cypionateCytochrome P450 3A7enzyme
Testosterone cypionateSolute carrier organic anion transporter family member 1A2transporter
Testosterone cypionateOrganic anion transporter 3transporter
Testosterone cypionateSolute carrier family 22 member 7transporter
Testosterone cypionateATP-dependent translocase ABCB1transporter
Testosterone cypionateHepatic sodium/bile acid cotransportertransporter
Testosterone cypionateSolute carrier family 22 member 3transporter
Testosterone cypionateSolute carrier family 22 member 4transporter
Testosterone cypionateBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
Testosterone cypionateCytochrome P450 1A1enzyme
Testosterone cypionateCytochrome P450 2A13enzyme
Testosterone cypionateCytochrome P450 2B6enzyme
Testosterone cypionateCytochrome P450 2C19enzyme
Testosterone cypionateCytochrome P450 2C8enzyme
Testosterone cypionateCytochrome P450 2C9enzyme
Testosterone cypionateCytochrome P450 3A43enzyme
Testosterone cypionateEstrogen receptortarget
Testosterone cypionateMineralocorticoid receptortarget
Testosterone cypionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone cypionateAromataseenzyme
Testosterone enanthateAndrogen receptortarget
Testosterone enanthateCytochrome P450 3A4enzyme
Testosterone enanthateAmine oxidase [flavin-containing] Aenzyme
Testosterone enanthateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
Testosterone enanthateAlbumincarrier
Testosterone enanthateSex hormone-binding globulincarrier
Testosterone enanthateCytochrome P450 3A5enzyme
Testosterone enanthateCytochrome P450 3A7enzyme
Testosterone enanthateSolute carrier organic anion transporter family member 1A2transporter
Testosterone enanthateOrganic anion transporter 3transporter
Testosterone enanthateSolute carrier family 22 member 7transporter
Testosterone enanthateATP-dependent translocase ABCB1transporter
Testosterone enanthateHepatic sodium/bile acid cotransportertransporter
Testosterone enanthateSolute carrier family 22 member 3transporter
Testosterone enanthateSolute carrier family 22 member 4transporter
Testosterone enanthateBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
Testosterone enanthateCytochrome P450 1A1enzyme
Testosterone enanthateCytochrome P450 2A13enzyme
Testosterone enanthateCytochrome P450 2B6enzyme
Testosterone enanthateCytochrome P450 2C19enzyme
Testosterone enanthateCytochrome P450 2C8enzyme
Testosterone enanthateCytochrome P450 2C9enzyme
Testosterone enanthateCytochrome P450 3A43enzyme
Testosterone enanthateEstrogen receptortarget
Testosterone enanthateMineralocorticoid receptortarget
Testosterone enanthate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone enanthateAromataseenzyme
Testosterone undecanoateAndrogen receptortarget
Testosterone undecanoateCytochrome P450 3A4enzyme
Testosterone undecanoateAmine oxidase [flavin-containing] Aenzyme
Testosterone undecanoateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
Testosterone undecanoateAlbumincarrier
Testosterone undecanoateSex hormone-binding globulincarrier
Testosterone undecanoateCytochrome P450 3A5enzyme
Testosterone undecanoateCytochrome P450 3A7enzyme
Testosterone undecanoateSolute carrier organic anion transporter family member 1A2transporter
Testosterone undecanoateOrganic anion transporter 3transporter
Testosterone undecanoateSolute carrier family 22 member 7transporter
Testosterone undecanoateATP-dependent translocase ABCB1transporter
Testosterone undecanoateHepatic sodium/bile acid cotransportertransporter
Testosterone undecanoateSolute carrier family 22 member 4transporter
Testosterone undecanoateBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
Testosterone undecanoateCytochrome P450 1A1enzyme
Testosterone undecanoateCytochrome P450 1B1enzyme
Testosterone undecanoateCytochrome P450 2A13enzyme
Testosterone undecanoateCytochrome P450 2B6enzyme
Testosterone undecanoateCytochrome P450 2C19enzyme
Testosterone undecanoateCytochrome P450 2C8enzyme
Testosterone undecanoateCytochrome P450 2C9enzyme
Testosterone undecanoateCytochrome P450 3A43enzyme
Testosterone undecanoate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone undecanoateSolute carrier family 22 member 2transporter
Testosterone undecanoateMultidrug and toxin extrusion protein 1transporter
Testosterone undecanoateSolute carrier organic anion transporter family member 1B3transporter
Testosterone undecanoateAromataseenzyme
EpitestosteroneAldo-keto reductase family 1 member C1target
EpitestosteroneAldo-keto reductase family 1 member C2target
5alpha-androstane-3beta,17alpha-diolSex hormone-binding globulincarrier