Serine protease 1

Details

Name
Serine protease 1
Kind
protein
Synonyms
  • 3.4.21.4
  • Anionic trypsin I
  • Anionic trypsin-I
  • Beta-trypsin
  • Cationic trypsinogen
  • Pretrypsinogen I
  • TRP1
  • TRY1
  • TRYP1
  • Trypsin I
  • Trypsin-1
Gene Name
PRSS1
UniProtKB Entry
P07477Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0016543|Serine protease 1
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
Number of residues
247
Molecular Weight
26557.88
Theoretical pI
6.48
GO Classification
Components
collagen-containing extracellular matrix
General Function
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates
Specific Function
metal ion binding
Pfam Domain Function
Signal Regions
1-15
Transmembrane Regions
Not Available
Cellular Location
Secreted, extracellular space
Gene sequence
>lcl|BSEQ0016544|Trypsin-1 (PRSS1)
ATGAATCCACTCCTGATCCTTACCTTTGTGGCAGCTGCTCTTGCTGCCCCCTTTGATGAT
GATGACAAGATCGTTGGGGGCTACAACTGTGAGGAGAATTCTGTCCCCTACCAGGTGTCC
CTGAATTCTGGCTACCACTTCTGTGGTGGCTCCCTCATCAACGAACAGTGGGTGGTATCA
GCAGGCCACTGCTACAAGTCCCGCATCCAGGTGAGACTGGGAGAGCACAACATCGAAGTC
CTGGAGGGGAATGAGCAGTTCATCAATGCAGCCAAGATCATCCGCCACCCCCAATACGAC
AGGAAGACTCTGAACAATGACATCATGTTAATCAAGCTCTCCTCACGTGCAGTAATCAAC
GCCCGCGTGTCCACCATCTCTCTGCCCACCGCCCCTCCAGCCACTGGCACGAAGTGCCTC
ATCTCTGGCTGGGGCAACACTGCGAGCTCTGGCGCCGACTACCCAGACGAGCTGCAGTGC
CTGGATGCTCCTGTGCTGAGCCAGGCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACC
AGCAACATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAGGGTGATTCT
GGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGTTGTCTCCTGGGGTGATGGCTGT
GCCCAGAAGAACAAGCCTGGAGTCTACACCAAGGTCTACAACTATGTGAAATGGATTAAG
AACACCATAGCTGCCAATAGCTAA
Chromosome Location
7
Locus
7q34
External Identifiers
ResourceLink
UniProtKB IDP07477
UniProtKB Entry NameTRY1_HUMAN
GenBank Protein ID521216
GenBank Gene IDM22612
GeneCard IDPRSS1
GenAtlas IDPRSS1
HGNC IDHGNC:9475
PDB ID(s)1FXY, 1TRN, 2RA3, 4WWY, 4WXV, 7QE8, 7QE9, 8H3S
KEGG IDhsa:5644
IUPHAR/Guide To Pharmacology ID2397
NCBI Gene ID5644
General References
  1. Emi M, Nakamura Y, Ogawa M, Yamamoto T, Nishide T, Mori T, Matsubara K: Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene. 1986;41(2-3):305-10. [Article]
  2. Rowen L, Koop BF, Hood L: The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science. 1996 Jun 21;272(5269):1755-62. [Article]
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  5. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Teich N, Ockenga J, Hoffmeister A, Manns M, Mossner J, Keim V: Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation. Gastroenterology. 2000 Aug;119(2):461-5. [Article]
  8. Koshikawa N, Yasumitsu H, Nagashima Y, Umeda M, Miyazaki K: Identification of one- and two-chain forms of trypsinogen 1 produced by a human gastric adenocarcinoma cell line. Biochem J. 1994 Oct 1;303 ( Pt 1):187-90. [Article]
  9. Kimland M, Russick C, Marks WH, Borgstrom A: Immunoreactive anionic and cationic trypsin in human serum. Clin Chim Acta. 1989 Sep 15;184(1):31-46. [Article]
  10. Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK Jr, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD: Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996 Oct;14(2):141-5. [Article]
  11. Teich N, Bauer N, Mossner J, Keim V: Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants. Am J Gastroenterol. 2002 Feb;97(2):341-6. [Article]
  12. Sahin-Toth M, Kukor Z, Nemoda Z: Human cationic trypsinogen is sulfated on Tyr154. FEBS J. 2006 Nov;273(22):5044-50. [Article]
  13. Szabo A, Salameh MA, Ludwig M, Radisky ES, Sahin-Toth M: Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids. PLoS One. 2014 Jul 10;9(7):e102063. doi: 10.1371/journal.pone.0102063. eCollection 2014. [Article]
  14. Gaboriaud C, Serre L, Guy-Crotte O, Forest E, Fontecilla-Camps JC: Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151. J Mol Biol. 1996 Jun 28;259(5):995-1010. [Article]
  15. Gorry MC, Gabbaizedeh D, Furey W, Gates LK Jr, Preston RA, Aston CE, Zhang Y, Ulrich C, Ehrlich GD, Whitcomb DC: Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology. 1997 Oct;113(4):1063-8. [Article]
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  17. Witt H, Luck W, Becker M: A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology. 1999 Jul;117(1):7-10. [Article]
  18. Ferec C, Raguenes O, Salomon R, Roche C, Bernard JP, Guillot M, Quere I, Faure C, Mercier B, Audrezet MP, Guillausseau PJ, Dupont C, Munnich A, Bignon JD, Le Bodic L: Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis. J Med Genet. 1999 Mar;36(3):228-32. [Article]
  19. Chen JM, Raguenes O, Ferec C, Deprez PH, Verellen-Dumoulin C: A CGC>CAT gene conversion-like event resulting in the R122H mutation in the cationic trypsinogen gene and its implication in the genotyping of pancreatitis. J Med Genet. 2000 Nov;37(11):E36. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
2H-Benzimidazol-2-amineexperimentalunknowntargetDetails
Bis(5-Amidino-Benzimidazolyl)MethaneexperimentalunknowntargetDetails
2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamideexperimentalunknowntargetDetails
CRA_17693experimentalunknowntargetDetails
N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl EsterexperimentalunknowntargetDetails
MonoisopropylphosphorylserineexperimentalunknowntargetDetails
[4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-MethanoneexperimentalunknowntargetDetails
Bis(5-Amidino-2-Benzimidazolyl)MethanoneexperimentalunknowntargetDetails
AmylamineexperimentalunknowntargetDetails
CRA_16847experimentalunknowntargetDetails
Bis-BenzamidineexperimentalunknowntargetDetails
CRA_17312experimentalunknowntargetDetails
Zk-806450experimentalunknowntargetDetails
[4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-AmmoniumexperimentalunknowntargetDetails
4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-BenzamidineexperimentalunknowntargetDetails
CRA_10762experimentalunknowntargetDetails
AminomethylcyclohexaneexperimentalunknowntargetDetails
BenzylamineexperimentalunknowntargetDetails
(1R,2S)-2-PhenylcyclopropanaminiumexperimentalunknowntargetDetails
RPR131247experimentalunknowntargetDetails
RWJ-56423experimentalyestargetinhibitorDetails
CRA_10972experimentalunknowntargetDetails
CRA_1801experimentalunknowntargetDetails
[N-[N-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-L-aspartyl]-D-(4-amidino-phenylalanyl)]-piperidineexperimentalunknowntargetDetails
BenzamidineexperimentalyestargetinhibitorDetails
Bis(5-Amidino-2-Benzimidazolyl)Methane KetoneexperimentalunknowntargetDetails
4-FluorobenzylamineexperimentalunknowntargetDetails
ZK-806711experimentalunknowntargetDetails
(2S,3R)-2-[[4-(Tert-butylcarbamoyl)piperazine-1-carbonyl]amino]-6-(diaminomethylideneamino)-3-formylhexanoic acidexperimentalunknowntargetDetails
bis(5-amidino-benzimidazolyl)methanone zincexperimentalunknowntargetDetails
CRA_11092experimentalunknowntargetDetails
Zinc;[amino-[2-[[5-[amino(azaniumylidene)methyl]benzimidazol-1-id-2-yl]methyl]benzimidazol-1-id-5-yl]methylidene]azaniumexperimentalunknowntargetDetails
[(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl EsterexperimentalunknowntargetDetails
N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-PiperazineexperimentalunknowntargetDetails
N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic AcidexperimentalunknowntargetDetails
CRA_23653experimentalunknowntargetDetails
Cyclotheonamide AexperimentalunknowntargetDetails
Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone HydrateexperimentalunknowntargetDetails
4-PhenylbutylamineexperimentalunknowntargetDetails
PhenethylamineexperimentalunknowntargetDetails
Aeruginosin 98-BexperimentalunknowntargetDetails
3-PhenylpropylamineexperimentalunknowntargetDetails
RPR128515experimentalunknowntargetDetails
Imino[2-(2-oxo-1,2-dihydro-3-pyridinyl)-1H-benzimidazol-5-yl]methanaminiumexperimentalunknowntargetDetails
CRA_9678experimentalunknowntargetDetails
PhosphorylisopropaneexperimentalunknowntargetDetails
4-PIPERIDIN-4-YLBUTANALexperimentalunknowntargetDetails
Aprotininapproved, investigational, withdrawnyestargetDetails
diethyl [(1R)-1,5-diaminopentyl]boronateexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidineexperimentalunknowntargetDetails
2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-CarboxamidineexperimentalunknowntargetDetails
2-(2-Hydroxy-Phenyl)-1h-Indole-5-CarboxamidineexperimentalyestargetinhibitorDetails
N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideexperimentalunknowntargetDetails
6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineexperimentalunknowntargetDetails
N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideexperimentalunknowntargetDetails
2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDEexperimentalunknowntargetDetails
2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDEexperimentalunknowntargetDetails
CRA-9334experimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamideexperimentalunknowntargetDetails
ZK-805623experimentalunknowntargetDetails
CRA_10655experimentalunknowntargetDetails
CRA_10656experimentalunknowntargetDetails
CRA_8696experimentalunknowntargetDetails
3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATEexperimentalunknowntargetDetails
CRA_9785experimentalunknowntargetDetails
CRA_1802experimentalunknowntargetDetails
CRA_9076experimentalunknowntargetDetails
6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidineexperimentalunknowntargetDetails
CRA_10991experimentalunknowntargetDetails
5-Amidino-BenzimidazoleexperimentalunknowntargetDetails
4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDEexperimentalunknowntargetDetails
Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-IsopropylesterexperimentalunknowntargetDetails
Hemi-BabimexperimentalunknowntargetDetails
DiminazeneexperimentalunknowntargetDetails
5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acidexperimentalunknowntargetDetails
CRA_10433experimentalunknowntargetDetails
CRA_1144experimentalunknowntargetDetails
4-Iodobenzo[B]Thiophene-2-CarboxamidineexperimentalunknowntargetDetails
Thieno[2,3-B]Pyridine-2-CarboxamidineexperimentalunknowntargetDetails
Benzo[B]Thiophene-2-CarboxamidineexperimentalunknowntargetDetails
1-(4-Amidinophenyl)-3-(4-Chlorophenyl)UreaexperimentalunknowntargetDetails
1-(2-Amidinophenyl)-3-(Phenoxyphenyl)UreaexperimentalunknowntargetDetails
+/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATEexperimentalunknowntargetDetails
2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDEexperimentalunknowntargetDetails
2-Naphthalenesulfonic acidexperimentalunknowntargetDetails
1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACIDexperimentalunknowntargetDetails
RWJ-51084experimentalunknowntargetDetails
2,5-bis-O-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-D-glucitolexperimentalunknowntargetDetails
2-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOLexperimentalunknowntargetDetails
2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOLexperimentalunknowntargetDetails
1,4:3,6-Dianhydro-2-O-(3-carbamimidoylphenyl)-5-O-(4-carbamimidoylphenyl)-D-glucitolexperimentalunknowntargetDetails
3,5-DiiodotyrosineexperimentalunknowntargetDetails
[N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATEexperimentalunknowntargetDetails
GabexateinvestigationalnoenzymeinhibitorDetails
NafamostatinvestigationalyestargetinhibitorDetails
CamostatexperimentalunknowntargetinhibitorDetails
Bortezomibapproved, investigationalyestargetinhibitorDetails
MelagatranexperimentalyestargetinhibitorDetails