Initial characterization of the human central proteome.

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Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J

Initial characterization of the human central proteome.

BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17.

PubMed ID
21269460 [ View in PubMed
]
Abstract

BACKGROUND: On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitously expressed in all human cells. Composition and properties of the central proteome are investigated through bioinformatics analyses. RESULTS: We experimentally identify a central proteome comprising 1,124 proteins that are ubiquitously and abundantly expressed in human cells using state of the art mass spectrometry and protein identification bioinformatics. The main represented functions are proteostasis, primary metabolism and proliferation. We further characterize the central proteome considering gene structures, conservation, interaction networks, pathways, drug targets, and coordination of biological processes. Among other new findings, we show that the central proteome is encoded by exon-rich genes, indicating an increased regulatory flexibility through alternative splicing to adapt to multiple environments, and that the protein interaction network linking the central proteome is very efficient for synchronizing translation with other biological processes. Surprisingly, at least 10% of the central proteome has no or very limited functional annotation. CONCLUSIONS: Our data and analysis provide a new and deeper description of the human central proteome compared to previous results thereby extending and complementing our knowledge of commonly expressed human proteins. All the data are made publicly available to help other researchers who, for instance, need to compare or link focused datasets to a common background.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
17-beta-hydroxysteroid dehydrogenase type 2P37059Details
Glycogen phosphorylase, liver formP06737Details
NAD(P) transhydrogenase, mitochondrialQ13423Details
Alcohol dehydrogenase class-3P11766Details
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialP50213Details
Tyrosine-protein kinase ABL1P00519Details
7-dehydrocholesterol reductaseQ9UBM7Details
Dehydrogenase/reductase SDR family member 4Q9BTZ2Details
RAF proto-oncogene serine/threonine-protein kinaseP04049Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialO00217Details
Phenylalanine--tRNA ligase alpha subunitQ9Y285Details
TransketolaseP29401Details
Pyridoxal kinaseO00764Details
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingQ15738Details
Pyruvate kinase PKLRP30613Details
Delta-aminolevulinic acid dehydrataseP13716Details
Prolyl 4-hydroxylase subunit alpha-1P13674Details
Serine--tRNA ligase, cytoplasmicP49591Details
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialP10515Details
L-lactate dehydrogenase B chainP07195Details
Acetyl-CoA acetyltransferase, mitochondrialP24752Details
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrialQ9HCC0Details
Alpha-aminoadipic semialdehyde synthase, mitochondrialQ9UDR5Details
Hypoxanthine-guanine phosphoribosyltransferaseP00492Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialO95299Details
Creatine kinase B-typeP12277Details
Ferritin light chainP02792Details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1Q02809Details
Pyruvate kinase PKMP14618Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5O43920Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialO75380Details
Methylsterol monooxygenase 1Q15800Details
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialP11177Details
Carcinoembryonic antigen-related cell adhesion molecule 1P13688Details
Adenine phosphoribosyltransferaseP07741Details
3-hydroxyisobutyrate dehydrogenase, mitochondrialP31937Details
Hemoglobin subunit alphaP69905Details
Aldehyde dehydrogenase, mitochondrialP05091Details
Alpha-aminoadipic semialdehyde dehydrogenaseP49419Details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialP19404Details
Mitochondrial inner membrane m-AAA protease component AFG3L2Q9Y4W6Details
Tubulin beta chainP07437Details
NAD-dependent malic enzyme, mitochondrialP23368Details
Cysteine desulfuraseQ9Y697Details
Succinate-semialdehyde dehydrogenase, mitochondrialP51649Details
Sigma non-opioid intracellular receptor 1Q99720Details
Biotin--protein ligaseP50747Details
NADH-cytochrome b5 reductase 3P00387Details
D-3-phosphoglycerate dehydrogenaseO43175Details
2-oxoglutarate dehydrogenase complex component E1Q02218Details
Glutamate--cysteine ligase catalytic subunitP48506Details
DNA ligase 3P49916Details
Cytochrome c oxidase subunit NDUFA4O00483Details
Creatine kinase U-type, mitochondrialP12532Details
NADH dehydrogenase [ubiquinone] 1 subunit C2O95298Details
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialP31040Details
Carnitine O-palmitoyltransferase 2, mitochondrialP23786Details
Glutamate dehydrogenase 1, mitochondrialP00367Details
Pyridoxine-5'-phosphate oxidaseQ9NVS9Details
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7P56937Details
Glutathione synthetaseP48637Details
Bifunctional glutamate/proline--tRNA ligaseP07814Details
Scavenger receptor class B member 1Q8WTV0Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialO75489Details
NADH-ubiquinone oxidoreductase chain 3P03897Details
Lysine--tRNA ligaseQ15046Details
DNA ligase 1P18858Details
NEDD8-activating enzyme E1 regulatory subunitQ13564Details
Leucine--tRNA ligase, mitochondrialQ15031Details
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicP21695Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6P56556Details
Calcium-transporting ATPase type 2C member 1P98194Details
Asparagine synthetase [glutamine-hydrolyzing]P08243Details
Ribosyldihydronicotinamide dehydrogenase [quinone]P16083Details
Angiotensin-converting enzymeP12821Details
Large neutral amino acids transporter small subunit 1Q01650Details
Valine--tRNA ligaseP26640Details
Pyrroline-5-carboxylate reductase 1, mitochondrialP32322Details
Tryptophan--tRNA ligase, cytoplasmicP23381Details
Tyrosine--tRNA ligase, cytoplasmicP54577Details
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrialQ02252Details
Microsomal triglyceride transfer protein large subunitP55157Details
Threonine--tRNA ligase 1, cytoplasmicP26639Details
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrialO75746Details
Neutral amino acid transporter B(0)Q15758Details
Adrenodoxin, mitochondrialP10109Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialO43674Details
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrialP30038Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10O96000Details
Purine nucleoside phosphorylaseP00491Details
4-aminobutyrate aminotransferase, mitochondrialP80404Details
5'-AMP-activated protein kinase subunit beta-1Q9Y478Details
Trifunctional enzyme subunit alpha, mitochondrialP40939Details
Cytosolic purine 5'-nucleotidaseP49902Details
Gamma-glutamyl hydrolaseQ92820Details
Carbonic anhydrase 1P00915Details
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialP13995Details
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrialQ9UJS0Details
ChronophinQ96GD0Details
Antithrombin-IIIP01008Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3O43676Details
Arginase-1P05089Details
4-trimethylaminobutyraldehyde dehydrogenaseP49189Details
HCG20471, isoform CRA_cQ5T1J1Details
Serine hydroxymethyltransferase, mitochondrialP34897Details
Alanine--tRNA ligase, cytoplasmicP49588Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4O95168Details
Sorbitol dehydrogenaseQ00796Details
Spermidine synthaseP19623Details
Retinol-binding protein 1P09455Details
S-adenosylmethionine synthase isoform type-2P31153Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialQ16795Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialO75251Details
Retinol-binding protein 4P02753Details
3-hydroxyacyl-CoA dehydrogenase type-2Q99714Details
GMP synthase [glutamine-hydrolyzing]P49915Details
Carbonic anhydrase 2P00918Details
Cystathionine beta-synthaseP35520Details
Thymidylate synthaseP04818Details
Ribonucleoside-diphosphate reductase large subunitP23921Details
Dihydrofolate reductaseP00374Details
Serine hydroxymethyltransferase, cytosolicP34896Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1O75438Details
Beta-adrenergic receptor kinase 1P25098Details
Acetyl-coenzyme A synthetase, cytoplasmicQ9NR19Details
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrialQ96I99Details
Tyrosine--tRNA ligase, mitochondrialQ9Y2Z4Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8P51970Details
Riboflavin kinaseQ969G6Details
AmidophosphoribosyltransferaseQ06203Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6O95139Details
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialQ16836Details
Guided entry of tail-anchored proteins factor CAMLGP49069Details
Dihydroorotate dehydrogenase (quinone), mitochondrialQ02127Details
Aspartate aminotransferase, mitochondrialP00505Details
KynureninaseQ16719Details
Neutrophil elastaseP08246Details
Isovaleryl-CoA dehydrogenase, mitochondrialP26440Details
Ferritin heavy chainP02794Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7O95182Details
Carnitine O-palmitoyltransferase 1, liver isoformP50416Details
S-adenosylmethionine synthase isoform type-1Q00266Details
Peroxisomal multifunctional enzyme type 2P51659Details
Annexin A1P04083Details
Ornithine aminotransferase, mitochondrialP04181Details
L-lactate dehydrogenase A chainP00338Details
RAC-alpha serine/threonine-protein kinaseP31749Details
Serine/threonine-protein kinase A-RafP10398Details
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3AQ14432Details
Serine palmitoyltransferase 1O15269Details
Caspase-1P29466Details
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialQ96RQ3Details
Monocarboxylate transporter 4O15427Details
Leucine carboxyl methyltransferase 1Q9UIC8Details
4-hydroxyphenylpyruvate dioxygenaseP32754Details
Corrinoid adenosyltransferase MMABQ96EY8Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5Q16718Details
Aldehyde dehydrogenase X, mitochondrialP30837Details
Neutral amino acid transporter AP43007Details
Aminoacylase-1Q03154Details
ATP synthase subunit delta, mitochondrialP30049Details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialP49821Details
Isoleucine--tRNA ligase, cytoplasmicP41252Details
Propionyl-CoA carboxylase alpha chain, mitochondrialP05165Details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialP28331Details
Low-density lipoprotein receptorP01130Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialO43181Details
SerotransferrinP02787Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7P17568Details
Retinal dehydrogenase 2O94788Details
Branched-chain-amino-acid aminotransferase, cytosolicP54687Details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialO75600Details
Argininosuccinate lyaseP04424Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Q9P0J0Details
Nicotinate-nucleotide pyrophosphorylase [carboxylating]Q15274Details
Aspartyl/asparaginyl beta-hydroxylaseQ12797Details
Aspartate aminotransferase, cytoplasmicP17174Details
AlbuminP02768Details
Chromodomain-helicase-DNA-binding protein 1O14646Details
Thyroxine-binding globulinP05543Details
Fibrinogen alpha chainP02671Details
Dihydropteridine reductaseP09417Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11Q86Y39Details
Glyceraldehyde-3-phosphate dehydrogenaseP04406Details
Methionine--tRNA ligase, cytoplasmicP56192Details
Propionyl-CoA carboxylase beta chain, mitochondrialP05166Details
Acyl carrier protein, mitochondrialO14561Details
DNA polymerase alpha catalytic subunitP09884Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2O43678Details
NADH-ubiquinone oxidoreductase chain 4P03905Details
Aldehyde dehydrogenase 1A1P00352Details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialO43837Details
Phenylalanine--tRNA ligase beta subunitQ9NSD9Details
Guanidinoacetate N-methyltransferaseQ14353Details
Cysteine dioxygenase type 1Q16878Details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialP08559Details
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialP45954Details
Squalene monooxygenaseQ14534Details
(3R)-3-hydroxyacyl-CoA dehydrogenaseQ92506Details
Mitochondrial carnitine/acylcarnitine carrier proteinO43772Details
Retinaldehyde dehydrogenase 3P47895Details
Peroxisomal bifunctional enzymeQ08426Details
Heme oxygenase 2P30519Details
Malate dehydrogenase, cytoplasmicP40925Details
Aldo-keto reductase family 1 member C3P42330Details
Retinol dehydrogenase 13Q8NBN7Details
Flavin reductase (NADPH)P30043Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9Q9Y6M9Details
ADP/ATP translocase 1P12235Details
Aldehyde dehydrogenase family 3 member A2P51648Details
Phosphoserine aminotransferaseQ9Y617Details
NADP-dependent malic enzymeP48163Details
Isobutyryl-CoA dehydrogenase, mitochondrialQ9UKU7Details
Glutamate--cysteine ligase regulatory subunitP48507Details
Asparagine--tRNA ligase, cytoplasmicO43776Details
Putative hydrolase DDAH2O95865Details
Choline-phosphate cytidylyltransferase AP49585Details
C-1-tetrahydrofolate synthase, cytoplasmicP11586Details
Glycine dehydrogenase (decarboxylating), mitochondrialP23378Details
Tyrosine-protein phosphatase non-receptor type 1P18031Details
ADP/ATP translocase 3P12236Details
Acetyl-CoA carboxylase 1Q13085Details
Hemoglobin subunit betaP68871Details
UMP-CMP kinaseP30085Details
Long-chain-fatty-acid--CoA ligase 1P33121Details
UDP-glucose 6-dehydrogenaseO60701Details
Glutathione reductase, mitochondrialP00390Details
Cytosolic phospholipase A2P47712Details
Serine palmitoyltransferase 2O15270Details
GDP-L-fucose synthaseQ13630Details
Monocarboxylate transporter 1P53985Details
Argininosuccinate synthaseP00966Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialO95169Details
5'-AMP-activated protein kinase catalytic subunit alpha-1Q13131Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3O95167Details
Peptidyl-prolyl cis-trans isomerase FKBP1AP62942Details
Retinoic acid-induced protein 3Q8NFJ5Details
Pyruvate carboxylase, mitochondrialP11498Details
Cysteine--tRNA ligase, cytoplasmicP49589Details
ADP/ATP translocase 2P05141Details
DNA polymerase alpha subunit BQ14181Details
Aldehyde dehydrogenase, dimeric NADP-preferringP30838Details
Branched-chain-amino-acid aminotransferase, mitochondrialO15382Details
Inosine-5'-monophosphate dehydrogenase 2P12268Details
Aspartate--tRNA ligase, cytoplasmicP14868Details
Pyrroline-5-carboxylate reductase 2Q96C36Details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialO75306Details
Sodium/potassium-transporting ATPase subunit alpha-1P05023Details
Methionine synthaseQ99707Details
Heme oxygenase 1P09601Details
Translocator proteinP30536Details
Dihydrolipoyl dehydrogenase, mitochondrialP09622Details
Histidine--tRNA ligase, cytoplasmicP12081Details
Biliverdin reductase AP53004Details
DNA topoisomerase 2-alphaP11388Details
Acetyl-coenzyme A synthetase 2-like, mitochondrialQ9NUB1Details
Aldo-keto reductase family 1 member B1P15121Details
ATPase GET3O43681Details
Phenylalanine-4-hydroxylaseP00439Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12Q9UI09Details
Glutamate dehydrogenase 2, mitochondrialP49448Details
Arginase-2, mitochondrialP78540Details
Inosine-5'-monophosphate dehydrogenase 1P20839Details
Short-chain specific acyl-CoA dehydrogenase, mitochondrialP16219Details
Methionine synthase reductaseQ9UBK8Details
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1O94760Details
Epidermal growth factor receptorP00533Details
Leucine--tRNA ligase, cytoplasmicQ9P2J5Details
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialP51553Details
5'-AMP-activated protein kinase subunit beta-2O43741Details
Farnesyl pyrophosphate synthaseP14324Details
Methylmalonyl-CoA mutase, mitochondrialP22033Details
Sphingosine-1-phosphate lyase 1O95470Details
Malate dehydrogenase, mitochondrialP40926Details
Cellular retinoic acid-binding protein 2P29373Details
Nicotinamide N-methyltransferaseP40261Details
Multidrug resistance-associated protein 1P33527Details
Cystathionine gamma-lyaseP32929Details
Glucocorticoid receptorP04150Details
Glutathione S-transferase kappa 1Q9Y2Q3Details
Glutathione S-transferase Mu 3P21266Details
Glutathione S-transferase PP09211Details
Glutathione S-transferase omega-1P78417Details
Glutathione peroxidase 1P07203Details
Glutathione peroxidase 2P18283Details
Glutathione S-transferase theta-1P30711Details
Maleylacetoacetate isomeraseO43708Details
Delta-1-pyrroline-5-carboxylate synthaseP54886Details
Glutaminase kidney isoform, mitochondrialO94925Details
Ephrin type-A receptor 2P29317Details
Dipeptidyl peptidase 4P27487Details
Perilipin-3O60664Details
L-xylulose reductaseQ7Z4W1Details
Dual specificity mitogen-activated protein kinase kinase 1Q02750Details
Protein-tyrosine kinase 2-betaQ14289Details
Protein kinase C beta typeP05771Details
CTP synthase 1P17812Details
Lanosterol 14-alpha demethylaseQ16850Details
Lysosomal alpha-glucosidaseP10253Details
Alpha-synucleinP37840Details
Trifunctional purine biosynthetic protein adenosine-3P22102Details
Protein S100-A13Q99584Details
Sulfotransferase 2A1Q06520Details
Cyclin-dependent kinase 5Q00535Details
Signal transducer and activator of transcription 5BP51692Details
DNA (cytosine-5)-methyltransferase 1P26358Details
CalpastatinP20810Details
Peroxiredoxin-5, mitochondrialP30044Details
Sepiapterin reductaseP35270Details
Alpha-2-macroglobulinP01023Details
Sialidase-1Q99519Details
Hepatocyte growth factor receptorP08581Details
Growth factor receptor-bound protein 2P62993Details
Apolipoprotein A-IIP02652Details
Mitogen-activated protein kinase 1P28482Details
Sulfotransferase 1A1P50225Details
Complement decay-accelerating factorP08174Details
Phosphatidylcholine transfer proteinQ9UKL6Details
Cytochrome bP00156Details
Cathepsin BP07858Details
Cathepsin DP07339Details
Bifunctional epoxide hydrolase 2P34913Details
Alpha-1-antitrypsinP01009Details
MyeloblastinP24158Details
Eukaryotic translation initiation factor 4EP06730Details
Fatty acid synthaseP49327Details
Lactoylglutathione lyaseQ04760Details
Spermine synthaseP52788Details
Apoptosis-inducing factor 1, mitochondrialO95831Details
Tissue factor pathway inhibitorP10646Details
Plasminogen activator inhibitor 2P05120Details
DNA topoisomerase 1P11387Details
Lysosomal acid glucosylceramidaseP04062Details
Inositol monophosphatase 2O14732Details
Transforming growth factor beta-1 proproteinP01137Details
Catenin beta-1P35222Details
Thiopurine S-methyltransferaseP51580Details
Aurora kinase AO14965Details
Parkinson disease protein 7Q99497Details
LactotransferrinP02788Details
Long-chain-fatty-acid--CoA ligase 4O60488Details
Glycine--tRNA ligaseP41250Details
Cytochrome b-c1 complex subunit 1, mitochondrialP31930Details
Cytochrome cP99999Details
Cathepsin GP08311Details
CalnexinP27824Details
Peptidyl-prolyl cis-trans isomerase AP62937Details
Rho-associated protein kinase 1Q13464Details
Mitogen-activated protein kinase 14Q16539Details
ATP-dependent translocase ABCB1P08183Details
Ferrochelatase, mitochondrialP22830Details
Protein-glutamine gamma-glutamyltransferase 2P21980Details
Solute carrier family 2, facilitated glucose transporter member 1P11166Details
AngiotensinogenP01019Details
Mitogen-activated protein kinase 3P27361Details
Glycogen synthase kinase-3 betaP49841Details
VitronectinP04004Details
ATP-binding cassette sub-family C member 2Q92887Details
Tyrosine-protein phosphatase non-receptor type 11Q06124Details
Cyclin-dependent kinase 2P24941Details
MyeloperoxidaseP05164Details
Aminopeptidase NP15144Details
Cyclin-dependent kinase 1P06493Details
Neutrophil gelatinase-associated lipocalinP80188Details
Intercellular adhesion molecule 1P05362Details
Nuclear factor NF-kappa-B p105 subunitP19838Details
Glucose-6-phosphate 1-dehydrogenaseP11413Details
Protein S100-A1P23297Details
Fatty acid CoA ligase Acsl3O95573Details
Endoplasmic reticulum chaperone BiPP11021Details
Hexokinase-1P19367Details
Ras-related C3 botulinum toxin substrate 1P63000Details
CD44 antigenP16070Details
Apolipoprotein EP02649Details
Heat shock protein HSP 90-alphaP07900Details
S-methyl-5'-thioadenosine phosphorylaseQ13126Details
Protein kinase C alpha typeP17252Details
Phospholipid hydroperoxide glutathione peroxidase GPX4P36969Details
Vitamin D-binding proteinP02774Details
Geranylgeranyl transferase type-1 subunit betaP53609Details
Protein-L-isoaspartate(D-aspartate) O-methyltransferaseP22061Details
Deoxyhypusine synthaseP49366Details
Inositol monophosphatase 1P29218Details
Beta-hexosaminidase subunit betaP07686Details
Inhibitor of nuclear factor kappa-B kinase subunit betaO14920Details
E3 ubiquitin-protein ligase XIAPP98170Details
Endothelial protein C receptorQ9UNN8Details
Caspase-3P42574Details
EndoplasminP14625Details
Microtubule-associated protein 1AP78559Details
Annexin A2P07355Details
RAC-beta serine/threonine-protein kinaseP31751Details
Cytochrome b5P00167Details
14-3-3 protein zeta/deltaP63104Details
ProsaposinP07602Details
Tissue factorP13726Details
Phosphatidylethanolamine-binding protein 1P30086Details
FibronectinP02751Details
Insulin-degrading enzymeP14735Details
NAD(P)H dehydrogenase [quinone] 1P15559Details
Quinone oxidoreductaseQ08257Details
ATP-binding cassette sub-family C member 4O15439Details
Glutathione S-transferase Mu 2P28161Details
Transforming protein RhoAP61586Details
Protein S100-PP25815Details
Glucose-6-phosphate isomeraseP06744Details
Fibroblast growth factor receptor 4P22455Details
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrialP33316Details
CatalaseP04040Details
Casein kinase II subunit alphaP68400Details
Serum amyloid P-componentP02743Details
m7GpppX diphosphataseQ96C86Details
Thymidylate kinaseP23919Details
Bifunctional purine biosynthesis protein ATICP31939Details
Isocitrate dehydrogenase [NADP] cytoplasmicO75874Details
Thymidine kinase, cytosolicP04183Details
Adenylate kinase isoenzyme 1P00568Details
Protein-glutamine gamma-glutamyltransferase EQ08188Details
Tyrosine-protein kinase BTKQ06187Details
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformP48736Details
Tyrosine-protein kinase SYKP43405Details
Acetyl-CoA acetyltransferase, cytosolicQ9BWD1Details
Galectin-3P17931Details
Tyrosine-protein kinase CSKP41240Details
Tubulin beta-4B chainP68371Details
MAP kinase-activated protein kinase 2P49137Details
GMP reductase 1P36959Details
Protein kinase C theta typeQ04759Details
Tubulin alpha-1C chainQ9BQE3Details
Tubulin alpha-4A chainP68366Details
Peptidyl-prolyl cis-trans isomerase F, mitochondrialP30405Details
Tubulin beta-4A chainP04350Details
Tubulin beta-3 chainQ13509Details
UDP-N-acetylhexosamine pyrophosphorylaseQ16222Details
Serine/threonine-protein phosphatase PP1-gamma catalytic subunitP36873Details
Lanosterol synthaseP48449Details
Adenosine 5'-monophosphoramidase HINT1P49773Details
Uridine-cytidine kinase 2Q9BZX2Details
Phosphatidylinositol transfer protein alpha isoformQ00169Details
UDP-glucose 4-epimeraseQ14376Details
Methionine aminopeptidase 2P50579Details
Glucosamine-6-phosphate isomerase 1P46926Details
DNA repair protein XRCC4Q13426Details
Coatomer subunit gamma-1Q9Y678Details
Uroporphyrinogen decarboxylaseP06132Details
Cathepsin SP25774Details
Suppressor of tumorigenicity 14 proteinQ9Y5Y6Details
2-iminobutanoate/2-iminopropanoate deaminaseP52758Details
Leukotriene A-4 hydrolaseP09960Details
Fructose-bisphosphate aldolase AP04075Details
AdenosylhomocysteinaseP23526Details
Bis(5'-adenosyl)-triphosphataseP49789Details
Ras-related protein Rab-9AP51151Details
Poly [ADP-ribose] polymerase 1P09874Details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrialP11310Details
Enoyl-CoA delta isomerase 1, mitochondrialP42126Details
Early endosome antigen 1Q15075Details
Hydroxyacylglutathione hydrolase, mitochondrialQ16775Details
Caspase-7P55210Details
Ras-related protein Rap-2aP10114Details
Serpin B5P36952Details
Kinesin-like protein KIF11P52732Details
Glycolipid transfer proteinQ9NZD2Details
Macrophage migration inhibitory factorP14174Details
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3O94766Details
Heat shock protein HSP 90-betaP08238Details
Cyclin-dependent kinase 7P50613Details
Glutaryl-CoA dehydrogenase, mitochondrialQ92947Details
ADP-ribose pyrophosphatase, mitochondrialQ9BW91Details
Interferon-stimulated gene 20 kDa proteinQ96AZ6Details
Peroxiredoxin-2P32119Details
Thioredoxin reductase 1, cytoplasmicQ16881Details
Fatty acid-binding protein 5Q01469Details
Catechol O-methyltransferaseP21964Details
Fibrinogen beta chainP02675Details
Fibrinogen gamma chainP02679Details
Laminin subunit alpha-5O15230Details
Keratin, type II cytoskeletal 8P05787Details
Laminin subunit beta-1P07942Details
Laminin subunit gamma-1P11047Details
CalreticulinP27797Details
Prolow-density lipoprotein receptor-related protein 1Q07954Details
Laminin subunit alpha-3Q16787Details
Syndecan-2P34741Details
Protein ERGIC-53P49257Details
Multiple coagulation factor deficiency protein 2Q8NI22Details
Retinoblastoma-associated proteinP06400Details
Procathepsin LP07711Details
Serpin B6P35237Details
Prolyl endopeptidaseP48147Details
Pyridoxal phosphate homeostasis proteinO94903Details
Glycogen phosphorylase, brain formP11216Details
Pyridoxal-dependent decarboxylase domain-containing protein 1Q6P996Details
Kynurenine--oxoglutarate transaminase 3Q6YP21Details
Alanine aminotransferase 2Q8TD30Details
Serine dehydratase-likeQ96GA7Details
Cyanocobalamin reductase / alkylcobalamin dealkylaseQ9Y4U1Details
Methylenetetrahydrofolate reductase (NADPH)P42898Details
Methionine adenosyltransferase 2 subunit betaQ9NZL9Details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2O00469Details
Thymidine phosphorylaseP19971Details
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3O60568Details
CDP-diacylglycerol--inositol 3-phosphatidyltransferaseO14735Details
Peptide deformylase, mitochondrialQ9HBH1Details
Prolyl 3-hydroxylase 1Q32P28Details
DNA oxidative demethylase ALKBH2Q6NS38Details
Cyclin-dependent kinase 9P50750Details
Prolyl 3-hydroxylase 3Q8IVL6Details
Prolyl 3-hydroxylase OGFOD1Q8N543Details
Cyclin-dependent kinase 6Q00534Details
Adenosine deaminaseP00813Details
Cyclin-dependent kinase 4P11802Details
Egl nine homolog 1Q9GZT9Details
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetaseP22234Details
Multifunctional protein CADP27708Details
Adenylosuccinate synthetase isozyme 2P30520Details
Aspartate--tRNA ligase, mitochondrialQ6PI48Details
Phosphoribosylformylglycinamidine synthaseO15067Details
Glutamine synthetaseP15104Details
Glutamine--tRNA ligaseP47897Details
Glutamine-dependent NAD(+) synthetaseQ6IA69Details
Methionine--tRNA ligase, mitochondrialQ96GW9Details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialO14521Details
Prolyl 4-hydroxylase subunit alpha-2O15460Details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialP21912Details
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialP53597Details
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrialP55809Details
Succinate dehydrogenase cytochrome b560 subunit, mitochondrialQ99643Details
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrialQ9P2R7Details
Mitochondrial dicarboxylate carrierQ9UBX3Details
N-acetyl-D-glucosamine kinaseQ9UJ70Details
5-oxoprolinaseO14841Details
Glutamyl aminopeptidaseQ07075Details
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrialQ5JPH6Details
Mitochondrial glutamate carrier 1Q9H936Details
Aspartyl aminopeptidaseQ9ULA0Details
Glutathione S-transferase 3, mitochondrialO14880Details
Thioredoxin domain-containing protein 12O95881Details
Microsomal glutathione S-transferase 1P10620Details
S-formylglutathione hydrolaseP10768Details
Glutaredoxin-1P35754Details
Probable glutathione peroxidase 8Q8TED1Details
Microsomal glutathione S-transferase 2Q99735Details
Sphingomyelin phosphodiesterase 4Q9NXE4Details
Glycine cleavage system H protein, mitochondrialP23434Details
Peroxisomal sarcosine oxidaseQ9P0Z9Details
Tryptophan--tRNA ligase, mitochondrialQ9UGM6Details
Probable cysteine--tRNA ligase, mitochondrialQ9HA77Details
Threonine--tRNA ligase, mitochondrialQ9BW92Details
Alanine--tRNA ligase, mitochondrialQ5JTZ9Details
All-trans-retinol 13,14-reductaseQ6NUM9Details
Retinol dehydrogenase 11Q8TC12Details
Retinol dehydrogenase 14Q9HBH5Details
Diacylglycerol kinase alphaP23743Details
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoformP62714Details
Isoleucine--tRNA ligase, mitochondrialQ9NSE4Details
Vitamin K epoxide reductase complex subunit 1-like protein 1Q8N0U8Details
Peptidyl-prolyl cis-trans isomerase HO43447Details
Peptidyl-prolyl cis-trans isomerase BP23284Details
Trans-3-hydroxy-L-proline dehydrataseQ96EM0Details
Asparaginyl-tRNA synthetaseQ96I59Details
Proteasome subunit beta type-1P20618Details
Proteasome subunit beta type-5P28074Details
Proteasome subunit beta type-2P49721Details
Guanylate kinaseQ16774Details
NADPH--cytochrome P450 reductaseP16435Details
Histone deacetylase 1Q13547Details
Histone deacetylase 2Q92769Details
Histone deacetylase 3O15379Details
Histone deacetylase 6Q9UBN7Details
Protein farnesyltransferase subunit betaP49356Details
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaP49354Details
Arachidonate 5-lipoxygenase-activating proteinP20292Details
Phosphatidylinositol 3-kinase regulatory subunit betaO00459Details
DNA-dependent protein kinase catalytic subunitP78527Details
Serine/threonine-protein kinase mTORP42345Details
Nuclear factor NF-kappa-B p100 subunitQ00653Details
Superoxide dismutase [Cu-Zn]P00441Details
NF-kappa-B essential modulatorQ9Y6K9Details
Small ribosomal subunit protein uS2P08865Details
Disintegrin and metalloproteinase domain-containing protein 10O14672Details
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformP42338Details
Nicotinamide phosphoribosyltransferaseP43490Details
DNA repair nuclease/redox regulator APEX1P27695Details
Protein kinase C delta typeQ05655Details
Alpha-galactosidase AP06280Details
DNA topoisomerase 2-betaQ02880Details
Histamine N-methyltransferaseP50135Details
Squalene synthaseP37268Details
Epithelial cell adhesion moleculeP16422Details
Ribonucleoside-diphosphate reductase subunit M2P31350Details
Ephrin type-B receptor 4P54760Details
Uridine phosphorylase 1Q16831Details
Keratin, type II cytoskeletal 7P08729Details
E3 ubiquitin-protein ligase UBR4Q5T4S7Details
NAD-dependent protein deacetylase sirtuin-1Q96EB6Details
Protein disulfide-isomeraseP07237Details
Non-selective voltage-gated ion channel VDAC1P21796Details
Voltage-dependent anion-selective channel protein 2P45880Details
Voltage-dependent anion-selective channel protein 3Q9Y277Details
Oxidoreductase HTATIP2Q9BUP3Details
Telomerase-binding protein EST1AQ86US8Details
N-terminal kinase-like proteinQ96KG9Details
Prostaglandin E synthase 3Q15185Details
Probable ATP-dependent RNA helicase DDX6P26196Details
Hypoxia-inducible factor 1-alpha inhibitorQ9NWT6Details
Actin nucleation-promoting factor WASP42768Details
Histone-lysine N-methyltransferase SETD7Q8WTS6Details
C-terminal-binding protein 1Q13363Details
GephyrinQ9NQX3Details
U1 small nuclear ribonucleoprotein AP09012Details
ATP-dependent Clp protease proteolytic subunit, mitochondrialQ16740Details
Protein S100-A11P31949Details
Mitogen-activated protein kinase 12P53778Details
Deoxycytidine kinaseP27707Details
Immunoglobulin heavy constant gamma 1P01857Details
Copper transport protein ATOX1O00244Details
Estradiol 17-beta-dehydrogenase 11Q8NBQ5Details
Beta-2-glycoprotein 1P02749Details
Protein S100-A6P06703Details
Dehydrogenase/reductase SDR family member 11Q6UWP2Details
Carbonyl reductase [NADPH] 1P16152Details
Focal adhesion kinase 1Q05397Details
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1O43252Details
Nucleoside diphosphate kinase AP15531Details
Antigen peptide transporter 1Q03518Details
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrialQ16698Details
Serine/threonine-protein phosphatase 5P53041Details
Trafficking protein particle complex subunit 3O43617Details
Annexin A3P12429Details
ADP-ribosylation factor 4P18085Details
GDP-mannose 4,6 dehydrataseO60547Details
Nucleoside diphosphate kinase BP22392Details
GalactokinaseP51570Details
Integrin beta-4P16144Details
Hydroxymethylglutaryl-CoA lyase, mitochondrialP35914Details
Calpain-1 catalytic subunitP07384Details
NAD-dependent protein deacylase sirtuin-5, mitochondrialQ9NXA8Details
E3 ubiquitin-protein transferase MAEAQ7L5Y9Details
CD9 antigenP21926Details
Cellular tumor antigen p53P04637Details
Serine/threonine-protein kinase Chk2O96017Details
Serine/threonine-protein kinase Chk1O14757Details
Cytochrome c oxidase subunit 2P00403Details
Thioredoxin reductase 2, mitochondrialQ9NNW7Details
Mitogen-activated protein kinase 13O15264Details
Amyloid-beta precursor proteinP05067Details
Tubulin beta-2A chainQ13885Details
Tubulin beta-2B chainQ9BVA1Details
Tubulin beta-6 chainQ9BUF5Details
Aurora kinase BQ96GD4Details
Puromycin-sensitive aminopeptidaseP55786Details
Bcl-2-like protein 2Q92843Details
Far upstream element-binding protein 1Q96AE4Details
cAMP-dependent protein kinase type II-alpha regulatory subunitP13861Details
cAMP-dependent protein kinase type I-alpha regulatory subunitP10644Details
High mobility group protein B1P09429Details
Heat shock protein beta-1P04792Details
Centromere-associated protein EQ02224Details
Apolipoprotein A-IP02647Details
Complement C3P01024Details
Caspase-8Q14790Details
Signal transducer and activator of transcription 3P40763Details
Ribosome-binding protein 1Q9P2E9Details
60S ribosome subunit biogenesis protein NIP7 homologQ9Y221Details
Microtubule-associated protein 4P27816Details
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2P16615Details
HLA class I histocompatibility antigen, A-3 alpha chainP04439Details
Alpha-mannosidase 2Q16706Details
Bcl-2-like protein 1Q07817Details
Casein kinase I isoform epsilonP49674Details
Histone deacetylase 5Q9UQL6Details
Adenosine kinaseP55263Details
6-phosphogluconate dehydrogenase, decarboxylatingP52209Details
Prostaglandin reductase 2Q8N8N7Details
V-type proton ATPase catalytic subunit AP38606Details
Geranylgeranyl pyrophosphate synthaseO95749Details
Rho-related GTP-binding protein RhoBP62745Details
Integrin beta-1P05556Details
Integrin alpha-VP06756Details
NischarinQ9Y2I1Details
Protein S100-A2P29034Details
Aldo-keto reductase family 1 member D1P51857Details
Ribonucleoside-diphosphate reductase subunit M2 BQ7LG56Details
DNA polymerase epsilon catalytic subunit AQ07864Details
DNA polymerase epsilon subunit 4Q9NR33Details
DNA polymerase epsilon subunit 3Q9NRF9Details
Cation-independent mannose-6-phosphate receptorP11717Details
Carbonic anhydrase-related proteinP35219Details
Tubulin gamma-1 chainP23258Details
Phosphatidylinositol 3-kinase catalytic subunit type 3Q8NEB9Details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortP63092Details
Cyclin-A2P20248Details
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Q13526Details
Nuclear receptor coactivator 2Q15596Details
Serine/threonine-protein kinase PLK1P53350Details
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformP30153Details
Lysozyme CP61626Details
Protein S100-A7P31151Details
cAMP-dependent protein kinase catalytic subunit alphaP17612Details
S-phase kinase-associated protein 1P63208Details
Mitogen-activated protein kinase 9P45984Details
Heat shock cognate 71 kDa proteinP11142Details
Beta-2-microglobulinP61769Details
Glycylpeptide N-tetradecanoyltransferase 2O60551Details
Low molecular weight phosphotyrosine protein phosphataseP24666Details
Dual specificity protein phosphatase 23Q9BVJ7Details
Mitogen-activated protein kinase 8P45983Details
Dual specificity protein kinase TTKP33981Details
Endothelin-converting enzyme 1P42892Details
Prostaglandin reductase 1Q14914Details
Poly [ADP-ribose] polymerase 2Q9UGN5Details
Serine/threonine-protein phosphatase PP1-alpha catalytic subunitP62136Details
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformP63151Details
Malonyl-CoA-acyl carrier protein transacylase, mitochondrialQ8IVS2Details
V-type proton ATPase subunit B, brain isoformP21281Details
ADP-ribosylation factor 1P84077Details
Large ribosomal subunit protein uL13P40429Details
Large ribosomal subunit protein uL14P62829Details
Large ribosomal subunit protein eL15P61313Details
Large ribosomal subunit protein eL19P84098Details
Large ribosomal subunit protein uL23P62750Details
Ribosomal protein uL24-likeQ9UNX3Details
Large ribosomal subunit protein uL2P62917Details
Large ribosomal subunit protein eL37P61927Details
Large ribosomal subunit protein uL3P39023Details
Large ribosomal subunit protein uL5P62913Details
NHP2-like protein 1P55769Details
Serine/threonine-protein kinase/endoribonuclease IRE1O75460Details
ATP synthase subunit alpha, mitochondrialP25705Details
ATP synthase subunit beta, mitochondrialP06576Details
ATP synthase subunit gamma, mitochondrialP36542Details
Triosephosphate isomeraseP60174Details
Cytochrome c1, heme protein, mitochondrialP08574Details
Cytochrome b-c1 complex subunit 2, mitochondrialP22695Details
Cytochrome b-c1 complex subunit 6, mitochondrialP07919Details
Cytochrome b-c1 complex subunit 8O14949Details
Cytochrome b-c1 complex subunit Rieske, mitochondrialP47985Details
Cytochrome b-c1 complex subunit 7P14927Details
Cytochrome b-c1 complex subunit 9Q9UDW1Details
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrialQ15118Details
Cytosol aminopeptidaseP28838Details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialQ16134Details
Protein kinase C iota typeP41743Details
Myosin-14Q7Z406Details
Proteasome subunit alpha type-1P25786Details
Proteasome subunit alpha type-2P25787Details
Proteasome subunit alpha type-3P25788Details
Proteasome subunit alpha type-4P25789Details
Proteasome subunit alpha type-5P28066Details
Proteasome subunit alpha type-6P60900Details
Proteasome subunit alpha type-7O14818Details
Proteasome subunit beta type-3P49720Details
Proteasome subunit beta type-4P28070Details
Proteasome subunit beta type-6P28072Details
Proteasome subunit beta type-7Q99436Details
Retinoid-inducible serine carboxypeptidaseQ9HB40Details
Pro-cathepsin HP09668Details
Casein kinase II subunit alpha'P19784Details
Cytochrome c oxidase subunit 4 isoform 1, mitochondrialP13073Details
Cytochrome c oxidase subunit 5A, mitochondrialP20674Details
Cytochrome c oxidase subunit 5B, mitochondrialP10606Details
Cytochrome c oxidase subunit 6CP09669Details
Cytochrome c oxidase subunit 7C, mitochondrialP15954Details
Cytochrome c oxidase subunit 6B1P14854Details
Fatty acid-binding protein, liverP07148Details
STE20-like serine/threonine-protein kinaseQ9H2G2Details
Calcium/calmodulin-dependent protein kinase type IVQ16566Details
Isopentenyl-diphosphate Delta-isomerase 1Q13907Details
Elongation factor-like GTPase 1Q7Z2Z2Details
Nuclear receptor coactivator 5Q9HCD5Details
MAP kinase-activated protein kinase 3Q16644Details
Hydroxymethylglutaryl-CoA synthase, cytoplasmicQ01581Details
GTPase KRasP01116Details
Geranylgeranyl transferase type-2 subunit alphaQ92696Details
Geranylgeranyl transferase type-2 subunit betaP53611Details
HLA class I histocompatibility antigen, B-27 alpha chainP01889Details
Mevalonate kinaseQ03426Details
Platelet-activating factor acetylhydrolase IB subunit alpha1Q15102Details
Calcium/calmodulin-dependent protein kinase type II subunit deltaQ13557Details
Serine/threonine-protein kinase 26Q9P289Details
Methionine aminopeptidase 1P53582Details
Profilin-1P07737Details
Enolase-phosphatase E1Q9UHY7Details
Peroxisomal acyl-coenzyme A oxidase 1Q15067Details
Calpain small subunit 1P04632Details
Tyrosine-protein kinase JAK1P23458Details
Annexin A5P08758Details
GelsolinP06396Details
DestrinP60981Details
Cofilin-1P23528Details
Rho-associated protein kinase 2O75116Details
Enoyl-CoA delta isomerase 2O75521Details
Protein phosphatase 3 catalytic subunit alphaQ08209Details
ADP-ribosylation factor 6P62330Details
Apolipoprotein MO95445Details
Actin-related protein 2/3 complex subunit 1BO15143Details
Actin-related protein 2P61160Details
Actin-related protein 3P61158Details
Actin-related protein 2/3 complex subunit 2O15144Details
Actin-related protein 2/3 complex subunit 3O15145Details
Actin-related protein 2/3 complex subunit 5O15511Details
Ribosomal protein S6 kinase alpha-1Q15418Details
Trafficking protein particle complex subunit 6BQ86SZ2Details
Trafficking protein particle complex subunit 5Q8IUR0Details
Trafficking protein particle complex subunit 4Q9Y296Details
Trafficking protein particle complex subunit 1Q9Y5R8Details
Elongation factor 2P13639Details
Myosin light chain 6BP14649Details
Profilin-2P35080Details
SRSF protein kinase 2P78362Details
3-hydroxyisobutyryl-CoA hydrolase, mitochondrialQ6NVY1Details
Glycylpeptide N-tetradecanoyltransferase 1P30419Details
AfadinP55196Details
Interleukin-1 receptor-associated kinase 4Q9NWZ3Details
Protein S100-A4P26447Details
Aldo-keto reductase family 1 member A1P14550Details
Aldo-keto reductase family 1 member B10O60218Details
CREB-binding proteinQ92793Details
Valacyclovir hydrolaseQ86WA6Details
Acyl-coenzyme A thioesterase 13Q9NPJ3Details
Mediator of RNA polymerase II transcription subunit 1Q15648Details
Calcium/calmodulin-dependent protein kinase type II subunit gammaQ13555Details
U6 snRNA-associated Sm-like protein LSm6P62312Details
Type II inositol 1,4,5-trisphosphate 5-phosphataseP32019Details
Ribose-5-phosphate isomeraseP49247Details
mRNA-capping enzymeO60942Details
Diphthine methyl ester synthaseQ9H2P9Details
RNA-splicing ligase RtcB homologQ9Y3I0Details
Inosine triphosphate pyrophosphataseQ9BY32Details
Stromal cell-derived factor 2Q99470Details
Mothers against decapentaplegic homolog 2Q15796Details
Protein arginine N-methyltransferase 3O60678Details
Eukaryotic peptide chain release factor GTP-binding subunit ERF3AP15170Details
Epsin-1Q9Y6I3Details
Superoxide dismutase [Mn], mitochondrialP04179Details
Phosphoglycerate kinase 1P00558Details
Thiosulfate sulfurtransferaseQ16762Details
Citrate synthase, mitochondrialO75390Details
Beta-enolaseP13929Details
Phosphoglucomutase-1P36871Details
Serpin B3P29508Details
HLA class II histocompatibility antigen, DQ beta 1 chainP01920Details
VimentinP08670Details
Uridine 5'-monophosphate synthaseP11172Details
Cytochrome b5 type BO43169Details
cAMP-dependent protein kinase catalytic subunit betaP22694Details
Acyl-CoA-binding proteinP07108Details
Adenylate kinase 2, mitochondrialP54819Details
Ras-related protein Rab-8BQ92930Details
NADPH:adrenodoxin oxidoreductase, mitochondrialP22570Details
Ras-related protein Rab-7aP51149Details
Guanine nucleotide-binding protein G(i) subunit alpha-1P63096Details
Galectin-1P09382Details
Cation-dependent mannose-6-phosphate receptorP20645Details
Inositol-3-phosphate synthase 1Q9NPH2Details
cAMP-dependent protein kinase type II-beta regulatory subunitP31323Details
Glycogenin-1P46976Details
Enoyl-CoA hydratase, mitochondrialP30084Details
Signal recognition particle 14 kDa proteinP37108Details
Aconitate hydratase, mitochondrialQ99798Details
NADH-cytochrome b5 reductase 1Q9UHQ9Details
Vesicle-fusing ATPaseP46459Details
Poly(A) polymerase alphaP51003Details
RadixinP35241Details
3-ketoacyl-CoA thiolase, peroxisomalP09110Details
V-type proton ATPase subunit C 1P21283Details
Isocitrate dehydrogenase [NADP], mitochondrialP48735Details
Ubiquitin-conjugating enzyme E2 D2P62837Details
FumarylacetoacetaseP16930Details
Unconventional myosin-IeQ12965Details
Ras-related protein Rab-5AP20339Details
ADP-ribosylation factor-like protein 1P40616Details
Palmitoyl-protein thioesterase 1P50897Details
Elongation factor Tu, mitochondrialP49411Details
Gamma-enolaseP09104Details
Cyclin-dependent kinases regulatory subunit 1P61024Details
T-complex protein 1 subunit gammaP49368Details
Pterin-4-alpha-carbinolamine dehydrataseP61457Details
Neuronal calcium sensor 1P62166Details
Ras-related protein Rab-11AP62491Details
GTP-binding nuclear protein RanP62826Details
Ras-related protein Ral-AP11233Details
N-acylneuraminate cytidylyltransferaseQ8NFW8Details
Carboxypeptidase DO75976Details
Acylphosphatase-2P14621Details
14-3-3 protein epsilonP62258Details
Transitional endoplasmic reticulum ATPaseP55072Details
Ubiquitin-like modifier-activating enzyme 1P22314Details
Sorting nexin-3O60493Details
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5O60264Details
2'-5'-oligoadenylate synthase 1P00973Details
Catechol O-methyltransferase domain-containing protein 1Q86VU5Details
Phosphoserine phosphataseP78330Details
Spectrin beta chain, non-erythrocytic 1Q01082Details
GTP-binding protein RhebQ15382Details
Protein arginine N-methyltransferase 1Q99873Details
Spliceosome RNA helicase DDX39BQ13838Details
Selenocysteine lyaseQ96I15Details
Versican core proteinP13611Details
Pyrroline-5-carboxylate reductase 3Q53H96Details
Cell division control protein 42 homologP60953Details
Kinesin-like protein KIF2CQ99661Details
Hepatocyte growth factor-regulated tyrosine kinase substrateO14964Details
Acireductone dioxygenaseQ9BV57Details
Serine/threonine-protein kinase TAO2Q9UL54Details
Small COPII coat GTPase SAR1BQ9Y6B6Details
Eukaryotic translation initiation factor 2 subunit 3P41091Details
ADP-ribosylation factor-like protein 3P36405Details
Peroxiredoxin-6P30041Details
Inhibitor of nuclear factor kappa-B kinase subunit alphaO15111Details
Keratin, type I cytoskeletal 12Q99456Details
Carbamoyl-phosphate synthase [ammonia], mitochondrialP31327Details
Bleomycin hydrolaseQ13867Details
Neutral alpha-glucosidase ABQ14697Details
Deoxycytidylate deaminaseP32321Details
Hyaluronan mediated motility receptorO75330Details
Cocaine esteraseO00748Details
Proteasome subunit beta type-9P28065Details
Proteasome subunit beta type-10P40306Details
Proteasome subunit beta type-8P28062Details
Breakpoint cluster region proteinP11274Details
Dual specificity mitogen-activated protein kinase kinase 2P36507Details
Anoctamin-1Q5XXA6Details
Kelch-like ECH-associated protein 1Q14145Details
RalA-binding protein 1Q15311Details
Carbonyl reductase [NADPH] 3O75828Details
Ethanolamine-phosphate cytidylyltransferaseQ99447Details
5'(3')-deoxyribonucleotidase, cytosolic typeQ8TCD5Details
Adenylate kinase 4, mitochondrialP27144Details
Transferrin receptor protein 1P02786Details
Serine-protein kinase ATMQ13315Details
Ribosomal protein S6 kinase alpha-3P51812Details
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseQ15125Details
Protein kinase C zeta typeQ05513Details
Membrane-associated progesterone receptor component 1O00264Details
Ras-related C3 botulinum toxin substrate 2P15153Details
5'-AMP-activated protein kinase catalytic subunit alpha-2P54646Details
5'-AMP-activated protein kinase subunit gamma-1P54619Details
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2Q14571Details
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3Q14573Details
Complement component 1 Q subcomponent-binding protein, mitochondrialQ07021Details
ThioredoxinP10599Details
Sodium/potassium-transporting ATPase subunit beta-1P05026Details
Arsenite methyltransferaseQ9HBK9Details
Sodium/potassium-transporting ATPase subunit beta-3P54709Details
Sodium/potassium-transporting ATPase subunit alpha-3P13637Details
Immunoglobulin heavy constant alpha 1P01876Details
Immunoglobulin heavy constant muP01871Details
Histone H1.4P10412Details
Cytoplasmic aconitate hydrataseP21399Details
Solute carrier family 2, facilitated glucose transporter member 8Q9NY64Details
Chloride intracellular channel protein 1O00299Details
Casein kinase II subunit betaP67870Details
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1P28907Details
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENP60484Details
Transcription factor p65Q04206Details
Ubiquitin carboxyl-terminal hydrolase isozyme L1P09936Details
Alpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1Details
Dihydropyrimidinase-related protein 2Q16555Details
Alpha-enolaseP06733Details
Protein PMLP29590Details
Programmed cell death protein 6O75340Details
Copper chaperone for superoxide dismutaseO14618Details
Protein SCO1 homolog, mitochondrialO75880Details
Nucleolar and coiled-body phosphoprotein 1Q14978Details
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Q15750Details
Protein O-GlcNAcaseO60502Details
UtrophinP46939Details
Peroxiredoxin-1Q06830Details
Apolipoprotein C-IIIP02656Details
Lysosomal protective proteinP10619Details
Tricarboxylate transport protein, mitochondrialP53007Details
Mitochondrial 2-oxodicarboxylate carrierQ9BQT8Details
Cytochrome c oxidase copper chaperoneQ14061Details
Metallothionein-1FP04733Details
CalbindinP05937Details
SorcinP30626Details
Calcineurin B homologous protein 1Q99653Details
PeflinQ9UBV8Details
Translationally-controlled tumor proteinP13693Details
Nucleobindin-1Q02818Details
Nucleobindin-2P80303Details
GrancalcinP28676Details
Calmodulin-2P0DP24Details
Calmodulin-3P0DP25Details
Protein S100-A16Q96FQ6Details
DNA-3-methyladenine glycosylaseP29372Details
Protein S100-A8P05109Details
60 kDa heat shock protein, mitochondrialP10809Details
Heat shock 70 kDa protein 13P48723Details
Small ribosomal subunit protein uS5P15880Details
Heterogeneous nuclear ribonucleoproteins A2/B1P22626Details
Heterogeneous nuclear ribonucleoprotein HP31943Details
Heterogeneous nuclear ribonucleoprotein H3P31942Details
Heterogeneous nuclear ribonucleoprotein LP14866Details
Splicing factor, proline- and glutamine-richP23246Details
Splicing factor 3A subunit 2Q15428Details
Small ribosomal subunit protein RACK1P63244Details
Alpha-actinin-1P12814Details
Annexin A4P09525Details
Stress-induced-phosphoprotein 1P31948Details
Eukaryotic translation initiation factor 6P56537Details
Eukaryotic initiation factor 4A-IP60842Details
14-3-3 protein beta/alphaP31946Details
Hepatoma-derived growth factorP51858Details
Proteasome activator complex subunit 1Q06323Details
Phosphoglycerate mutase 1P18669Details
Ran-specific GTPase-activating proteinP43487Details
AfaminP43652Details
Protein disulfide-isomerase A3P30101Details
Serpin B9P50453Details
Integrin alpha-5P08648Details
Frataxin, mitochondrialQ16595Details
Cystatin-BP04080Details
Protein S100-A9P06702Details
HuntingtinP42858Details
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1Q8N1G2Details
Neural cell adhesion molecule L1P32004Details
Copine-1Q99829Details
Minor histocompatibility antigen H13Q8TCT9Details
Prohibitin-2Q99623Details
Flap endonuclease 1P39748Details
ATP synthase subunit aP00846Details
Eukaryotic translation initiation factor 3 subunit FO00303Details
Heat shock-related 70 kDa protein 2P54652Details
RuvB-like 2Q9Y230Details
Splicing factor 3B subunit 3Q15393Details
ATP synthase subunit e, mitochondrialP56385Details
ATP synthase subunit g, mitochondrialO75964Details
Diablo IAP-binding mitochondrial proteinQ9NR28Details
Heterogeneous nuclear ribonucleoprotein FP52597Details
Heterogeneous nuclear ribonucleoprotein KP61978Details
Heat shock 70 kDa protein 4P34932Details
10 kDa heat shock protein, mitochondrialP61604Details
Heat shock protein 105 kDaQ92598Details
Nuclear migration protein nudCQ9Y266Details
26S proteasome regulatory subunit 6AP17980Details
Protein S100-A10P60903Details
Splicing factor 3A subunit 3Q12874Details
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1Q969G3Details
Tumor protein D54O43399Details
Tropomyosin alpha-1 chainP09493Details
Tropomyosin alpha-3 chainP06753Details
Tropomyosin alpha-4 chainP67936Details
Ubiquitin carboxyl-terminal hydrolase 14P54578Details
14-3-3 protein etaQ04917Details
14-3-3 protein thetaP27348Details
Proliferating cell nuclear antigenP12004Details
Alpha-2-HS-glycoproteinP02765Details
Apolipoprotein A-IVP06727Details
Chromobox protein homolog 5P45973Details
Inter-alpha-trypsin inhibitor heavy chain H2P19823Details
Keratin, type II cytoskeletal 1P04264Details
Keratin, type I cytoskeletal 10P13645Details
Keratin, type II cytoskeletal 2 epidermalP35908Details
Keratin, type I cytoskeletal 9P35527Details
Pigment epithelium-derived factorP36955Details
Lys-63-specific deubiquitinase BRCC36P46736Details
DermcidinP81605Details
DesmoplakinP15924Details
HornerinQ86YZ3Details
Inter-alpha-trypsin inhibitor heavy chain H4Q14624Details
Immunoglobulin J chainP01591Details
Junction plakoglobinP14923Details
Keratin, type I cytoskeletal 14P02533Details
Keratin, type I cytoskeletal 16P08779Details
Keratin, type II cytoskeletal 5P13647Details
Keratin, type II cytoskeletal 6AP02538Details
Pregnancy zone proteinP20742Details
Amyloid beta precursor like protein 2Q06481Details
Far upstream element-binding protein 2Q92945Details
ATP synthase subunit O, mitochondrialP48047Details
Cysteine and glycine-rich protein 1P21291Details
Filamin-AP21333Details
Heterogeneous nuclear ribonucleoprotein D0Q14103Details
Heterochromatin protein 1-binding protein 3Q5SSJ5Details
Ras GTPase-activating-like protein IQGAP1P46940Details
NucleophosminP06748Details
Large ribosomal subunit protein uL16P27635Details
Large ribosomal subunit protein eL14P50914Details
Large ribosomal subunit protein eL18Q07020Details
Large ribosomal subunit protein uL29P42766Details
Large ribosomal subunit protein uL4P36578Details
Small ribosomal subunit protein uS15P62277Details
Small ribosomal subunit protein eS17P08708Details
Small ribosomal subunit protein uS13P62269Details
Small ribosomal subunit protein eS19P39019Details
Small ribosomal subunit protein eS28P62857Details
Small ribosomal subunit protein uS7P46782Details
Small ribosomal subunit protein eS6P62753Details
Small ribosomal subunit protein eS8P62241Details
Small ribosomal subunit protein uS4P46781Details
Splicing factor 1Q15637Details
Small nuclear ribonucleoprotein Sm D2P62316Details
Serine/arginine-rich splicing factor 4Q08170Details
Transgelin-2P37802Details
ZyxinQ15942Details
Sulfotransferase 1A3P0DMM9Details
Serine/arginine-rich splicing factor 1Q07955Details
Survival motor neuron proteinB4DP61Details
TransgelinQ01995Details
Myosin-9P35579Details
Probable ATP-dependent RNA helicase DDX5P17844Details
Splicing factor 3B subunit 1O75533Details
Atypical kinase COQ8A, mitochondrialQ8NI60Details
Serine/threonine-protein kinase 24Q9Y6E0Details
Serine/threonine-protein kinase 3Q13188Details
Serine/threonine-protein kinase 38Q15208Details
Serine/threonine-protein kinase 38-likeQ9Y2H1Details
STE20/SPS1-related proline-alanine-rich protein kinaseQ9UEW8Details
Serine/threonine-protein kinase TAO1Q7L7X3Details
Serine/threonine-protein kinase TAO3Q9H2K8Details
Serine/threonine-protein kinase TBK1Q9UHD2Details
Serine/threonine-protein kinase tousled-like 1Q9UKI8Details
Serine/threonine-protein kinase tousled-like 2Q86UE8Details
TRAF2 and NCK-interacting protein kinaseQ9UKE5Details
Serine/threonine-protein kinase ULK3Q6PHR2Details
AP2-associated protein kinase 1Q2M2I8Details
Atypical kinase COQ8B, mitochondrialQ96D53Details
Tyrosine-protein kinase BlkP51451Details
BMP-2-inducible protein kinaseQ9NSY1Details
Calcium/calmodulin-dependent protein kinase type 1Q14012Details
Citron Rho-interacting kinaseO14578Details
Casein kinase I isoform alphaP48729Details
Eukaryotic translation initiation factor 2-alpha kinase 1Q9BQI3Details
Interferon-induced, double-stranded RNA-activated protein kinaseP19525Details
eIF-2-alpha kinase GCN2Q9P2K8Details
Cyclin-G-associated kinaseO14976Details
Glycogen synthase kinase-3 alphaP49840Details
Interleukin-1 receptor-associated kinase 1P51617Details
Dual specificity mitogen-activated protein kinase kinase 3P46734Details
Dual specificity mitogen-activated protein kinase kinase 6P52564Details
Mitogen-activated protein kinase kinase kinase 4Q9Y6R4Details
Mitogen-activated protein kinase kinase kinase kinase 1Q92918Details
Mitogen-activated protein kinase kinase kinase kinase 4O95819Details
Serine/threonine-protein kinase MARK1Q9P0L2Details
Serine/threonine-protein kinase MARK2Q7KZI7Details
MAP/microtubule affinity-regulating kinase 3P27448Details
CLIP-associating protein 1Q7Z460Details
Misshapen-like kinase 1Q8N4C8Details
Macrophage-stimulating protein receptorQ04912Details
Serine/threonine-protein kinase Nek1Q96PY6Details
Serine/threonine-protein kinase Nek9Q8TD19Details
Serine/threonine-protein kinase OSR1O95747Details
Serine/threonine-protein kinase PAK 1Q13153Details
Serine/threonine-protein kinase PAK 2Q13177Details
Serine/threonine-protein kinase PAK 4O96013Details
Phosphatidylinositol 4-kinase betaQ9UBF8Details
Phosphatidylinositol 5-phosphate 4-kinase type-2 betaP78356Details
Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaQ8TBX8Details
Serine/threonine-protein kinase N1Q16512Details
Serine/threonine-protein kinase N2Q16513Details
Serine/threonine-protein kinase PRP4 homologQ13523Details
Serine/threonine-protein kinase RIO1Q9BRS2Details
Serine/threonine-protein kinase RIO2Q9BVS4Details
Serine/threonine-protein kinase RIO3O14730Details
Receptor-interacting serine/threonine-protein kinase 1Q13546Details
Receptor-interacting serine/threonine-protein kinase 2O43353Details
Serine/threonine-protein kinase 10O94804Details
Epoxide hydrolase 1P07099Details
ADP-ribosylation factor-like protein 2P36404Details
Inositol polyphosphate 1-phosphataseP49441Details
Ribulose-phosphate 3-epimeraseQ96AT9Details
B-cell antigen receptor complex-associated protein beta chainP40259Details
Phosphoglycerate kinase 2P07205Details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrialQ16822Details
Exportin-1O14980Details
POU domain, class 2, transcription factor 1P14859Details
Sulfotransferase 1A4P0DMN0Details
HLA class II histocompatibility antigen, DR alpha chainP01903Details
HLA class II histocompatibility antigen, DR beta 5 chainQ30154Details
Prohibitin 1P35232Details
Hexokinase-2P52789Details
DystrophinP11532Details
Nucleotide triphosphate diphosphatase NUDT15Q9NV35Details
Voltage-gated potassium channel subunit beta-2Q13303Details
ATP-citrate synthaseP53396Details
Long-chain fatty acid transport protein 2O14975Details
Sodium-coupled neutral amino acid symporter 2Q96QD8Details
Thiamine-triphosphataseQ9BU02Details
Zinc transporter ZIP1Q9NY26Details
Metal cation symporter ZIP14Q15043Details
Apolipoprotein B-100P04114Details
HaptoglobinP00738Details
Tumor-associated calcium signal transducer 2P09758Details
Serum paraoxonase/arylesterase 2Q15165Details
V-type proton ATPase subunit d 1P61421Details
V-type proton ATPase subunit S1Q15904Details
Tyrosine-protein phosphatase non-receptor type 12Q05209Details
Tyrosine-protein phosphatase non-receptor type 6P29350Details
V-type proton ATPase 16 kDa proteolipid subunit cP27449Details
V-type proton ATPase 116 kDa subunit a 2Q9Y487Details
V-type proton ATPase subunit DQ9Y5K8Details
V-type proton ATPase subunit FQ16864Details
V-type proton ATPase subunit E 1P36543Details
V-type proton ATPase subunit HQ9UI12Details
V-type proton ATPase subunit G 1O75348Details
Mitochondrial potassium channelQ96ER9Details
Plasma membrane calcium-transporting ATPase 1P20020Details
Plasma membrane calcium-transporting ATPase 4P23634Details
Beta-galactosidaseP16278Details
Leucyl-cystinyl aminopeptidaseQ9UIQ6Details
Cell surface hyaluronidase CEMIP2Q9UHN6Details
Molybdopterin synthase catalytic subunitO96007Details
Receptor protein-tyrosine kinaseQ504U8Details
3-ketoacyl-CoA thiolase, mitochondrialP42765Details
Serine/threonine-protein kinase ATRQ13535Details
HLA class I histocompatibility antigen, alpha chain EP13747Details
Eukaryotic translation initiation factor 4E-binding protein 1Q13541Details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2P16885Details
Lysine-specific histone demethylase 1AO60341Details
Signal transducer and activator of transcription 1-alpha/betaP42224Details
Histone acetyltransferase p300Q09472Details
ELAV-like protein 1Q15717Details
Dual specificity mitogen-activated protein kinase kinase 4P45985Details
3-oxoacyl-[acyl-carrier-protein] reductaseQ8N4T8Details
Hemoglobin subunit gamma-1P69891Details
Hemoglobin subunit gamma-2P69892Details
Apoptosis regulator BAXQ07812Details
CD276 antigenQ5ZPR3Details
Bcl-2-binding component 3, isoforms 1/2Q9BXH1Details
IgG receptor FcRn large subunit p51P55899Details
Asialoglycoprotein receptor 1P07306Details