Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors.
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Miescher GC, Taylor V, Olivieri G, Mindermann T, Schrock E, Steck AJ
Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors.
Brain Res Mol Brain Res. 1997 Jun;46(1-2):17-24.
- PubMed ID
- 9191074 [ View in PubMed]
- Abstract
EHK-1 is a neuronal ELK-related receptor tyrosine kinase which interacts with multiple, membrane-anchored ligands. Recent experiments have suggested a role for some of these ligands in the formation of neuronal pathways. Here, we report the isolation of human EHK-1 cDNAs and the localization of the human EHK-1 gene to chromosome 4q12. Six EHK-1 mRNA splice variants encoding cell-surface receptors with catalytic domains were identified in adult human brain where a 120-kDa EHK-1 protein predominates. Immunohistochemistry for EHK-1 reveals a dendritic staining pattern in cortical neurons and cerebellar Purkinje cells and a marked accumulation of EHK-1 in the somas of pyramidal neurons within the cortex and hippocampus. Interestingly, we have identified lineage aberrant expression of EHK-1 in a number of human gliomas. In addition to functions during development, EHK-1 may be involved in the maintenance of the adult nervous system and contribute to glioma development.