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In Reply: Dr Albanes and Dr Huang and colleagues stress the potential importance of trials with 0 events. In our primary analyses, we calculated RRs and therefore excluded trials with 0 events (405 trials with 40 000 participants). Sensitivity analyses including 1 hypothetical trial with 1 death in each study arm and 40 000 participants reached the same conclusion as the primary analysis (RR, 1.02; 95% CI; 0.98-1.06). Trials with 0 events are likely to have specific characteristics (eg, short duration, low dose). We did not use imputation techniques because they are based on the assumption that any trial can be replaced by a new randomly chosen trial in the same sample.¹

Albanes argues that vitamin A is not an antioxidant. However, vitamin A has antioxidant activity.² In our systematic review, we included 2 trials of vitamin A monotherapy. The trials found no significant effect of vitamin A, and their exclusion had . . . [Full Text of this Article]

Lise Lotte Gluud, MD, DrMedSci
lgluud@ctu.rh.dk
Copenhagen Trial Unit
Center for Clinical Intervention Research
Rigshospitalet
Copenhagen University Hospital
Copenhagen, Denmark

Goran Bjelakovic, MD, DrMedSci
Department of Internal Medicine, Gastroenterology, and Hepatology
University of Nis
Nis, Serbia

Dimitrinka Nikolova, MA
Copenhagen Trial Unit
Center for Clinical Intervention Research
Rigshospitalet
Copenhagen University Hospital

Rosa G. Simonetti, MD
Cattedra di Gastroenterologia
Ospedale V. Cervello
Palermo, Italy

Christian Gluud, MD, DrMedSci
Copenhagen Trial Unit
Center for Clinical Intervention Research
Rigshospitalet
Copenhagen University Hospital

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