GPR182
| G protein spregnuti receptor 182 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR182; 7TMR; AMR; MGC34399; gamrh; hrhAMR | ||||||||||
| Vanjski ID | OMIM: 605307 MGI: 109545 HomoloGene: 5255 IUPHAR: GPR182 GeneCards: GPR182 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 11318 | 11536 | |||||||||
| Ensembl | ENSG00000166856 | n/a | |||||||||
| UniProt | O15218 | n/a | |||||||||
| RefSeq (mRNA) | NM_007264 | NM_007412 | |||||||||
| RefSeq (protein) | NP_009195 | NP_031438 | |||||||||
| Lokacija (UCSC) |
Chr 12: 55.67 - 55.68 Mb | n/a | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GPR182 (ili G protein spregnuti receptor 182) je ljudski gen (i asocirani protein) koji je orfan GPCR.[1]
Kad je ovaj gen bio kloniran prvi put, pretpostavljeno je da kodira adrenomedulin receptor.[2] Međutim kad je korespondirajući protein izražen, utvrđeno je da ne proizvodi respons na adrenomedulin (ADM).[3]
Naknadno je bilo pokazano da jedan drugi GPCR receptor, CALCRL u kompleksu sa RAMP2 može da funkcioniše kao ADM receptor.[4]
Literatura
[уреди | уреди извор]- ^ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (2003). „The G protein-coupled receptor repertoires of human and mouse”. Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903—8. PMC 153653
. PMID 12679517. doi:10.1073/pnas.0230374100.
- ^ Hänze J, Dittrich K, Dötsch J, Rascher W (1997). „Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system”. Biochem. Biophys. Res. Commun. 240 (1): 183—8. PMID 9367907. doi:10.1006/bbrc.1997.7631.
- ^ Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (1998). „Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response”. Biochem. Biophys. Res. Commun. 244 (3): 832—7. PMID 9535752. doi:10.1006/bbrc.1998.8349.
- ^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (1998). „RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor”. Nature. 393 (6683): 333—9. PMID 9620797. doi:10.1038/30666.
Dodatna literatura
[уреди | уреди извор]- Lah JJ, Frishman WH (2002). „Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential.”. Heart disease (Hagerstown, Md.). 2 (3): 259—65. PMID 11728267.
- Mukoyama M; Sugawara A; Nagae T; et al. (2002). „Role of adrenomedullin and its receptor system in renal pathophysiology.”. Peptides. 22 (11): 1925—31. PMID 11754983. doi:10.1016/S0196-9781(01)00525-3.
- Fowler DE, Wang P (2002). „The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).”. Int. J. Mol. Med. 9 (5): 443—9. PMID 11956648.
- Kato J, Kitamura K, Kangawa K, Eto T (1995). „Receptors for adrenomedullin in human vascular endothelial cells.”. Eur. J. Pharmacol. 289 (2): 383—5. PMID 7621913. doi:10.1016/0922-4106(95)90117-5.
- Martínez A, Miller MJ, Catt KJ, Cuttitta F (1997). „Adrenomedullin receptor expression in human lung and in pulmonary tumors.”. J. Histochem. Cytochem. 45 (2): 159—64. PMID 9016306.
- Hänze J, Dittrich K, Dötsch J, Rascher W (1997). „Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system.”. Biochem. Biophys. Res. Commun. 240 (1): 183—8. PMID 9367907. doi:10.1006/bbrc.1997.7631.
- Martínez A; Elsasser TH; Muro-Cacho C; et al. (1997). „Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument.”. Endocrinology. 138 (12): 5597—604. PMID 9389548. doi:10.1210/en.138.12.5597.
- Kennedy SP; Sun D; Oleynek JJ; et al. (1998). „Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.”. Biochem. Biophys. Res. Commun. 244 (3): 832—7. PMID 9535752. doi:10.1006/bbrc.1998.8349.
- Jiménez N; Calvo A; Martínez A; et al. (1999). „Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate.”. J. Histochem. Cytochem. 47 (9): 1167—78. PMID 10449538.
- Kuwasako K; Kitamura K; Ito K; et al. (2002). „The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors.”. J. Biol. Chem. 276 (52): 49459—65. PMID 11591721. doi:10.1074/jbc.M108369200.
- Forneris M; Gottardo L; Albertin G; et al. (2002). „Expression and function of adrenomedullin and its receptors in Conn's adenoma cells.”. Int. J. Mol. Med. 8 (6): 675—9. PMID 11712085.
- Hänze J; Groneberg DA; Rose F; et al. (2002). „Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia.”. Biochem. Biophys. Res. Commun. 291 (5): 1160—5. PMID 11883938. doi:10.1006/bbrc.2002.6595.
- Dumont CE; Muff R; Flühmann B; et al. (2003). „Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.”. Brain Res. 955 (1-2): 64—71. PMID 12419522. doi:10.1016/S0006-8993(02)03365-6.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Chosa E; Hamada H; Kitamura K; et al. (2003). „Expression of adrenomedullin and its receptor by chondrocyte phenotype cells.”. Biochem. Biophys. Res. Commun. 303 (1): 379—86. PMID 12646214. doi:10.1016/S0006-291X(03)00347-4.
- Xu P; Dai AG; Zhou HD; et al. (2004). „[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]”. Zhonghua Jie He He Hu Xi Za Zhi. 26 (12): 765—8. PMID 14720432.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.