FZD7

Uvojiti receptor 7
Uvojiti receptor 7
Identifikatori
Simboli	FZD7; FzE3
Vanjski ID	OMIM: 603410 MGI: 108570 HomoloGene: 20751 IUPHAR: FZD7 GeneCards: FZD7 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • receptorsko vezivanje; • proteinsko vezivanje; • Wnt proteinsko vezivanje; • vezivanje PDZ domena;
Celularna komponenta	• citoplazma; • ćelijska površina; • integralno sa membranom; • sinaptosom; • membrana neuronske projekcije;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • razvoj vaskulature; • morfogeneza odlivnog trakta; • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	8324
Ensembl	ENSG00000155760
UniProt	O75084
RefSeq (mRNA)	NM_003507.1
RefSeq (protein)	NP_003498.1
Lokacija (UCSC)	Chr 2:; 202.9 - 202.9 Mb
PubMed pretraga	[1]

Uvojiti-7 je protein koji je kod ljudi kodiran FZD7 genom.^[1]^[2]^[3]

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD7 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Izražavanje FZD7 gena može da umanji APC funkciju i pojača beta-katenin-posredovane signale u slabo diferenciranom ljudskim karcinomima jednjaka.^[3]

Interakcije

FZD7 formira interakcije sa DLG4.^[4]

Reference

^ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc Natl Acad Sci U S A. 95 (17): 10164—9. PMC 21479 . PMID 9707618. doi:10.1073/pnas.95.17.10164.
^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun. 252 (1): 117—22. PMID 9813155. doi:10.1006/bbrc.1998.9607.
^ ^а ^б „Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)”.
^ Hering, Heike; Sheng Morgan (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. Netherlands. 521 (1–3): 185—9. ISSN 0014-5793. PMID 12067714. doi:10.1016/S0014-5793(02)02831-4.

Literatura

Finch PW; He X; Kelley MJ (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770—5. PMC 21233 . PMID 9192640. doi:10.1073/pnas.94.13.6770.
Hering H, Sheng M (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. 521 (1–3): 185—9. PMID 12067714. doi:10.1016/S0014-5793(02)02831-4.
Strausberg RL; Feingold EA; Grouse LH (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Yao R, Natsume Y, Noda T (2005). „MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap”. Oncogene. 23 (36): 6023—30. PMID 15195140. doi:10.1038/sj.onc.1207817.
Omoto S; Hayashi T; Kitahara K (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81—90. PMID 15370539. doi:10.1080/13816810490514270.
Gerhard DS; Wagner L; Feingold EA (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Vincan E; Darcy PK; Smyth MJ (2005). „Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth”. Differentiation. 73 (4): 142—53. PMID 15901282. doi:10.1111/j.1432-0436.2005.00015.x.
Rual JF; Venkatesan K; Hao T (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.
Lim J; Hao T; Shaw C (2006). „A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell. 125 (4): 801—14. PMID 16713569. doi:10.1016/j.cell.2006.03.032.
Vincan E; Darcy PK; Farrelly CA (2007). „Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids”. Oncogene. 26 (16): 2340—52. PMID 17016432. doi:10.1038/sj.onc.1210026.
Struewing IT; Barnett CD; Zhang W (2007). „Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1”. Exp. Cell Res. 313 (16): 3526—41. PMID 17716656. doi:10.1016/j.yexcr.2007.07.012.

Vidi još

Uvojiti receptori

Spoljašnje veze

„Frizzled Receptors: FZD₇”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.

[pmid9707618-1] Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc Natl Acad Sci U S A. 95 (17): 10164—9. PMC 21479 . PMID 9707618. doi:10.1073/pnas.95.17.10164.

[pmid9813155-2] Sagara N, Toda G, Hirai M, Terada M, Katoh M (1998). „Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7”. Biochem Biophys Res Commun. 252 (1): 117—22. PMID 9813155. doi:10.1006/bbrc.1998.9607.

[entrez-3] а ^б „Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)”.

[pmid12067714-4] Hering, Heike; Sheng Morgan (2002). „Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95”. FEBS Lett. Netherlands. 521 (1–3): 185—9. ISSN 0014-5793. PMID 12067714. doi:10.1016/S0014-5793(02)02831-4.

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