OPN1LW
| edit |
| Opsin 1, senzitivan na dugačke talasne dužine | |||||||||||
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| Identifikatori | |||||||||||
| Simboli | OPN1LW; CBP; CBBM; RCP | ||||||||||
| Vanjski ID | OMIM: 303900 MGI: 1097692 HomoloGene: 68064 GeneCards: OPN1LW Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5956 | 14539 | |||||||||
| Ensembl | ENSG00000102076 | ENSMUSG00000031394 | |||||||||
| UniProt | P04000 | O35599 | |||||||||
| RefSeq (mRNA) | NM_020061 | NM_008106 | |||||||||
| RefSeq (protein) | NP_064445 | NP_032132 | |||||||||
| Lokacija (UCSC) | Chr X: 153.06 - 153.08 Mb | Chr X: 70.38 - 70.4 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
OPN1LW, crveno-senzitivni opsin, je protein koji je kod ljudi kodiran OPN1LW genom.[1]
Ovaj gen kodira pigment iz familije opsina koji apsorbuje svetlost. On se naziva crveni fotopigment kupastih ćelija, ili opsin senzitivan na dugačke talasne dužine. Opsini su grupa G-protein spregnutih receptora sa sedam transmembranskih domena, ekstracelularnim N-terminusnim domenom, i citosolnim C-terminusom. Ovaj gen i opsinski geni srednjih-talasnih dužina su grupisani na X hromozomu. Česte neravnomerne rekombinacije i konverzije gena se mogu javiti između tih sekvenci. X hromozomi mogu da imaju spajanja gena opsina srednje i duge talasne dužine, ili višestruke kopije tih gena. Defekti ovog gena su uzrok parcijalne slepoće za boje.[1]
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- Voegel JJ, Heine MJ, Tini M, et al. (1998). „The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.”. EMBO J. 17 (2): 507–19. DOI:10.1093/emboj/17.2.507. PMC 1170401. PMID 9430642.
- Zhao Z, Hewett-Emmett D, Li WH (1998). „Frequent gene conversion between human red and green opsin genes.”. J. Mol. Evol. 46 (4): 494–6. DOI:10.1007/PL00013147. PMID 9541545.
- Nakayama TA, Zhang W, Cowan A, Kung M (1999). „Mutagenesis studies of human red opsin: trp-281 is essential for proper folding and protein-retinal interactions.”. Biochemistry 37 (50): 17487–94. DOI:10.1021/bi982077u. PMID 9860863.
- John SK, Smith JE, Aguirre GD, Milam AH (2000). „Loss of cone molecular markers in rhodopsin-mutant human retinas with retinitis pigmentosa.”. Mol. Vis. 6: 204–15. PMID 11063754.
- Ueyama H, Kuwayama S, Imai H, et al. (2002). „Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies.”. Biochem. Biophys. Res. Commun. 294 (2): 205–9. DOI:10.1016/S0006-291X(02)00458-8. PMID 12051694.
- Fitzgerald KA, Rowe DC, Barnes BJ, et al. (2003). „LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.”. J. Exp. Med. 198 (7): 1043–55. DOI:10.1084/jem.20031023. PMC 2194210. PMID 14517278.
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- Ross MT, Grafham DV, Coffey AJ, et al. (2005). „The DNA sequence of the human X chromosome.”. Nature 434 (7031): 325–37. DOI:10.1038/nature03440. PMC 2665286. PMID 15772651.