Frederick Crane

Nadh Oxidase Assay For Neoplasia Determination

Application

#5605810 Feb 25, 1997

Filed

Apr 5, 1994

Inventor

D. James Morr e (West Lafayette, IN) · Steven R. Byrn (West Lafayette, IN) · Frederick L. Crane (West Lafayette, IN) · Dorothy M. Morr e (West Lafayette, IN)

Appl. No.

8/222799

Assignee

Purdue Research Foundation (West Lafayett, IN)

International Classification

C12Q 126, C12N 999

U.S. Classification

435 25

Abstract

NADH oxidase is shown to be a target for a variety of uses in diagnosis and therapy. Particularly, the NADH oxidase associated with neoplastic cells is immunologically and biologically different from NADH oxidase associated with normal cells. Thus, the presence of tumor cells in patients can be monitored by monitoring the NADH oxidase of serum. In addition, use of the NADH oxidase associated with tumor cells provides opportunities for assays for screening drugs which are specific for neoplastic cells and can serve as anticancer drugs or growth inhibitors.

Method And Apparatus For Providing Security Features In Paper

Application

#4437935 Mar 20, 1984

Filed

Jun 3, 1981

Inventor

Frederick G. Crane (Dalton, MA)

Appl. No.

6/269850

Assignee

Crane and Company (Dalton, MA)

International Classification

D21D 300, D21H 510

U.S. Classification

162103

Abstract

A security device is integrally combined with the fibres of the paper in a paper-making process. A carrier web of water-dispersible fibres carrying the security element is brought into contact with the paper stock during the paper-making process. The carrier web becomes rapidly dispersed upon contact with the wet stock leaving the security element firmly attached to the paper fibres in the stock. In one embodiment, the security element comprises a plastic diffraction grating structure. In a further embodiment, the carrier web comprises an open porous structure for enhancing intermixing with the paper stock.