Familial idiopathic atrial fibrillation with bradyarrhythmia
- PMID: 8750801
- DOI: 10.1007/BF02115617
Familial idiopathic atrial fibrillation with bradyarrhythmia
Abstract
A 10-year-old boy is reported who presented with idiopathic atrial fibrillation and bradyarrhythmia. After history of intrauterine and postnatal bradycardia, atrial fibrillation was first documented electrocardiographically at 16 months of age. An underlying structural heart disease was not evident. At the age of 10 years, implantation of a permanent ventricular demand pacemaker was indicated after syncope due to severe bradyarrhythmia. The family history revealed five persons of four generations with bradyarrhythmias. Idiopathic atrial fibrillation known since childhood was documented in three close relatives. A high grade AV block resulting in bradyarrhythmias and the occurrence of ST-T-changes in precordial leads could be demonstrated in all affected family members suggesting a diffuse general conduction abnormality in these patients. In this family, idiopathic atrial fibrillation seems to be transmitted as an autosomal dominant trait.
Conclusion: Atrial fibrillation without underlying heart disease is extremely rare in children. Careful electrocardiographic follow-up of these patients and the evaluation of ECG recordings of all family members is recommended.
Similar articles
-
[Familial idiopathic atrial fibrillation with bradyarrhythmia].Z Kardiol. 1993 Nov;82(11):674-7. Z Kardiol. 1993. PMID: 8291288 German.
-
Clinical relevance of atrial fibrillation/flutter, stroke, pacemaker implant, and heart failure in Emery-Dreifuss muscular dystrophy: a long-term longitudinal study.Stroke. 2003 Apr;34(4):901-8. doi: 10.1161/01.STR.0000064322.47667.49. Epub 2003 Mar 20. Stroke. 2003. PMID: 12649505
-
Prevalence and Prognostic Significance of Bradyarrhythmias in Patients Screened for Atrial Fibrillation vs Usual Care: Post Hoc Analysis of the LOOP Randomized Clinical Trial.JAMA Cardiol. 2023 Apr 1;8(4):326-334. doi: 10.1001/jamacardio.2022.5526. JAMA Cardiol. 2023. PMID: 36790817 Free PMC article.
-
[Bradycardia-induced syncope].Ther Umsch. 1997 Mar;54(3):144-50. Ther Umsch. 1997. PMID: 9333979 Review. German.
-
[Syncope in bradycardic cardiac arrhythmias].Herz. 1993 Jun;18(3):182-6. Herz. 1993. PMID: 8330853 Review. German.
Cited by
-
Fetal Arrhythmias: Genetic Background and Clinical Implications.Pediatr Cardiol. 2019 Feb;40(2):247-256. doi: 10.1007/s00246-018-2008-3. Epub 2018 Nov 26. Pediatr Cardiol. 2019. PMID: 30478614 Review.
-
Genomics of Atrial Fibrillation.Curr Cardiol Rep. 2016 Jun;18(6):55. doi: 10.1007/s11886-016-0735-8. Curr Cardiol Rep. 2016. PMID: 27139902 Free PMC article. Review.
-
Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.Nat Commun. 2014 Aug 21;5:4664. doi: 10.1038/ncomms5664. Nat Commun. 2014. PMID: 25144323 Free PMC article.
-
T-type channels in the sino-atrial and atrioventricular pacemaker mechanism.Pflugers Arch. 2014 Apr;466(4):791-9. doi: 10.1007/s00424-014-1482-6. Epub 2014 Feb 27. Pflugers Arch. 2014. PMID: 24573175 Review.
-
Familial aggregation in lone atrial fibrillation.Hum Genet. 2005 Nov;118(2):179-84. doi: 10.1007/s00439-005-0034-8. Epub 2005 Nov 15. Hum Genet. 2005. PMID: 16133178
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical