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Link to original content: http://pubmed.ncbi.nlm.nih.gov/7384810/
Evolution of the hemoglobin S and C genes in world populations - PubMed Skip to main page content
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. 1980 Jul 18;209(4454):388-91.
doi: 10.1126/science.7384810.

Evolution of the hemoglobin S and C genes in world populations

Y W Kan, A M Dozy

Evolution of the hemoglobin S and C genes in world populations

Y W Kan et al. Science. .

Abstract

A polymorphic HpaI endonuclease recognition site on the 3' side of the beta-globin gene was used to analyze the evolution of the beta-globin gene mutants S and C. Study of the world wide distribution of the normal and variant HpaI sites showed that the mutation which resulted in the variant 13.0-kilobase fragment arose in a localized region in West Africa. It predated the hemoglobin S and C mutations, both of which arose separately from a chromosome with the variant 13.0-kilobase HpaI site. In contrast, the sickle genes in other parts of Africa and in Asia are associated with the normal 7.6-kilobase HpaI fragment, indicating that the sickle mutations in these other areas arose separately from that in West Africa.

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