Cilia and vesicular particles in the endocrine pancreas of the Mongolian gerbil
- PMID: 4918214
- PMCID: PMC2107918
- DOI: 10.1083/jcb.45.3.532
Cilia and vesicular particles in the endocrine pancreas of the Mongolian gerbil
Abstract
Though the general appearance and the cellular composition of the pancreatic islets of the Mongolian gerbil (Meriones unguiculatus) conformed to those of most other rodent species, some peculiar ultrastructural details were found. Thus there were diversiform, mainly vesicular particles with varying electron opacity in these islets. The vesicular particles showed a clear association to cilia which seemed to possess a basic fiber pattern of 9 + 0. The basal bodies were localized in the cytoplasm of the islet parenchymal cells, most often in the beta-cells, and the vesicular particles occurred in the portions of cilia that were protruding into intercellular spaces. The cilia were often swollen, and the vesicular particles were mainly found in the space between the ciliary membranes and the longitudinal fibers. A few vesicular particles could be seen inside and sometimes seemingly in contact with these fibers. Occasionally, there were morphologically similar structures in the cytoplasm of adjacent beta-cells. The vesicular particles were differentiated from the vesicles occurring in nerve structures by their larger size, as well as by their heterogeneous shape and electron opacity. The nature of the vesicular particles and the significance of their presence in cilia and in the cytoplasm of some of the islet cells remain unknown. Among other possibilities, it is, however, suggested that the vesicular particles may represent secretory material.
Similar articles
-
Obesity and pancreatic islet hyperplasia in the Mongolian gerbil.Diabetologia. 1972 Aug;8(4):274-82. doi: 10.1007/BF01225571. Diabetologia. 1972. PMID: 4564648 No abstract available.
-
Aspects of the ultrastructure and function of the subcommissural organ in the Mongolian gerbil (Meriones unguiculatus).J Submicrosc Cytol Pathol. 2001 Jan-Apr;33(1-2):73-82. J Submicrosc Cytol Pathol. 2001. PMID: 11686412
-
Cellular composition of the pancreatic islets in Mongolian gerbils (Meriones unguiculatus).Anat Histol Embryol. 1994 Jun;23(2):120-7. doi: 10.1111/j.1439-0264.1994.tb00244.x. Anat Histol Embryol. 1994. PMID: 7978346
-
Submicroscopic cytodifferentiation.Ergeb Anat Entwicklungsgesch. 1971;45(4):7-118. Ergeb Anat Entwicklungsgesch. 1971. PMID: 4337387 Review. No abstract available.
-
Novel aspects of intra-islet communication: Primary cilia and filopodia.Adv Biol Regul. 2023 Jan;87:100919. doi: 10.1016/j.jbior.2022.100919. Epub 2022 Oct 4. Adv Biol Regul. 2023. PMID: 36266190 Review.
Cited by
-
Structure, interaction and nervous connectivity of beta cell primary cilia.Nat Commun. 2024 Oct 24;15(1):9168. doi: 10.1038/s41467-024-53348-5. Nat Commun. 2024. PMID: 39448638 Free PMC article.
-
Keeping pace: the primary cilium as the conducting baton of the islet.Diabetologia. 2024 May;67(5):773-782. doi: 10.1007/s00125-024-06096-6. Epub 2024 Feb 14. Diabetologia. 2024. PMID: 38353726 Free PMC article. Review.
-
Scanning electron microscopy of human islet cilia.Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2302624120. doi: 10.1073/pnas.2302624120. Epub 2023 May 19. Proc Natl Acad Sci U S A. 2023. PMID: 37205712 Free PMC article.
-
Islet cilia and glucose homeostasis.Front Cell Dev Biol. 2022 Dec 1;10:1082193. doi: 10.3389/fcell.2022.1082193. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36531945 Free PMC article. Review.
-
Cilia Action in Islets: Lessons From Mouse Models.Front Endocrinol (Lausanne). 2022 Jun 23;13:922983. doi: 10.3389/fendo.2022.922983. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35813631 Free PMC article. Review.
