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Link to original content: http://pubmed.ncbi.nlm.nih.gov/39517291/
The Effects of Interventions with Glucosinolates and Their Metabolites in Cruciferous Vegetables on Inflammatory Bowel Disease: A Review - PubMed Skip to main page content
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Review
. 2024 Nov 1;13(21):3507.
doi: 10.3390/foods13213507.

The Effects of Interventions with Glucosinolates and Their Metabolites in Cruciferous Vegetables on Inflammatory Bowel Disease: A Review

Jichun Zhao  1   2   3 , Xiaoqin Zhang  1 , Fuhua Li  1   2   3 , Xiaojuan Lei  1   2   3 , Lihong Ge  4 , Honghai Li  1   2   3 , Nan Zhao  5 , Jian Ming  1   2   3
Affiliations
Review

The Effects of Interventions with Glucosinolates and Their Metabolites in Cruciferous Vegetables on Inflammatory Bowel Disease: A Review

Jichun Zhao et al. Foods. .

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract which affects millions of individuals worldwide. Despite advancements in treatment options, there is increasing interest in exploring natural interventions with minimal side effects. Cruciferous vegetables, such as broccoli, cabbage, and radishes, contain bioactive compounds known as glucosinolates (GLSs), which have shown promising effects in alleviating IBD symptoms. This review aims to provide a comprehensive overview of the physiological functions and mechanisms of cruciferous GLSs and their metabolites in the context of IBD. Reviewed studies demonstrated that GLSs attenuated all aspects of IBD, including regulating the intestinal microbiota composition, exerting antioxidant and anti-inflammatory effects, restoring intestinal barrier function, and regulating epigenetic mechanisms. In addition, a few interventions with GLS supplementation in clinical studies were also discussed. However, there are still several challenges and remaining knowledge gaps, including variations in animals' experimental outcomes, the bioavailability of certain compounds, and few clinical trials to validate their effectiveness in human subjects. Addressing these issues will contribute to a better understanding of the therapeutic potential of cruciferous GLSs and their metabolites in the management of IBD.

Keywords: IBD; anti-inflammatory; antioxidant; cruciferous vegetables; glucosinolates; gut microbiota.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The attenuating mechanism of GLSs and metabolites on IBD through anti-inflammatory and antioxidant activity, maintaining the intestinal barrier, gut microbiota modulation and modulating epigenetics.
See this image and copyright information in PMC

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