iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: http://pubmed.ncbi.nlm.nih.gov/39451518/
TRIM25, TRIM28 and TRIM59 and Their Protein Partners in Cancer Signaling Crosstalk: Potential Novel Therapeutic Targets for Cancer - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 25;46(10):10745-10761.
doi: 10.3390/cimb46100638.

TRIM25, TRIM28 and TRIM59 and Their Protein Partners in Cancer Signaling Crosstalk: Potential Novel Therapeutic Targets for Cancer

De Chen Chiang  1 , Beow Keat Yap  1
Affiliations
Review

TRIM25, TRIM28 and TRIM59 and Their Protein Partners in Cancer Signaling Crosstalk: Potential Novel Therapeutic Targets for Cancer

De Chen Chiang et al. Curr Issues Mol Biol. .

Abstract

Aberrant expression of TRIM proteins has been correlated with poor prognosis and metastasis in many cancers, with many TRIM proteins acting as key oncogenic factors. TRIM proteins are actively involved in many cancer signaling pathways, such as p53, Akt, NF-κB, MAPK, TGFβ, JAK/STAT, AMPK and Wnt/β-catenin. Therefore, this review attempts to summarize how three of the most studied TRIMs in recent years (i.e., TRIM25, TRIM28 and TRIM59) are involved directly and indirectly in the crosstalk between the signaling pathways. A brief overview of the key signaling pathways involved and their general cross talking is discussed. In addition, the direct interacting protein partners of these TRIM proteins are also highlighted in this review to give a picture of the potential protein-protein interaction that can be targeted for future discovery and for the development of novel therapeutics against cancer. This includes some examples of protein partners which have been proposed to be master switches to various cancer signaling pathways.

Keywords: TRIM25; TRIM28; TRIM59; cancer; pathway; tripartite motif.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
TRIM25, TRIM28 and TRIM59 in the signaling crosstalk between p53, Akt, NF-κB, MAPK p38, TGFβ, AMPK, JAK/STAT and Wnt/β-catenin pathways. For simplicity, only crosstalk that directly involves the interacting protein partners of TRIM25, TRIM28 and TRIM59 are shown in the diagram.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Hatakeyama S. TRIM family proteins: Roles in autophagy, immunity, and carcinogenesis. Trends Biochem. Sci. 2017;42:297–311. doi: 10.1016/j.tibs.2017.01.002. - DOI - PubMed
    1. Venuto S., Merla G. E3 ubiquitin ligase TRIM proteins, cell cycle and mitosis. Cells. 2019;8:510. doi: 10.3390/cells8050510. - DOI - PMC - PubMed
    1. McNab F.W., Rajsbaum R., Stoye J.P., O’Garra A. Tripartite-motif proteins and innate immune regulation. Curr. Opin. Immunol. 2011;23:46–56. doi: 10.1016/j.coi.2010.10.021. - DOI - PubMed
    1. Mallery D.L., McEwan W.A., Bidgood S.R., Towers G.J., Johnson C.M., James L.C. Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21) Proc. Natl. Acad. Sci. USA. 2010;107:19985–19990. doi: 10.1073/pnas.1014074107. - DOI - PMC - PubMed
    1. Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., et al. The tripartite motif family identifies cell compartments. EMBO J. 2001;20:2140–2151. doi: 10.1093/emboj/20.9.2140. - DOI - PMC - PubMed

Grants and funding

This research received no external funding.

LinkOut - more resources