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Case Reports
. 2024 Aug 30;12(9):e9305.
doi: 10.1002/ccr3.9305. eCollection 2024 Sep.

Psychedelic-assisted therapy for palliative care within a home treatment setting: A case report

Seragnoli Federico  1   2 , Martignoni Geo  3 , Martignoni Entela  3 , Silke Bachmann  1   4 , Rabitti Elisa  5 , Cavuto Silvio  6 , Dubus Zoë  7 , Penzenstadler Louise  1 , Thorens Gabriel  1 , Billieux Joël  2 , Zullino Daniele  1   8
Affiliations
Case Reports

Psychedelic-assisted therapy for palliative care within a home treatment setting: A case report

Seragnoli Federico et al. Clin Case Rep. .

Abstract

Key clinical message: This case study describes the feasibility and safety of psychedelic-assisted therapy (PAT) as a home-based intervention for a patient with throat cancer experiencing significant existential distress. The patient tolerated the intervention well. This case supports the feasibility and safety of PAT for patients with life-threatening conditions in a home setting.

Abstract: Psychedelic-assisted therapy (PAT), as it is practiced today, merges traditional psychotherapeutic techniques with the use of psychedelics such as LSD, psilocybin, or MDMA with the aim of unlocking deeper insights in patients and treating mental conditions that are resistant to other forms of therapy. The present case study describes the safety of PAT as a home-based intervention for a patient with throat cancer experiencing significant existential distress. The patient tolerated the intervention well and was asked to report on measures of anxiety, depression, and distress related to his somatic condition. The observations provided by this clinical case report align with previous findings, suggesting that PAT can be safely applied to potentially provide relief from existential distress in patients with life-threatening conditions. As this is a single-case study, generalizations should be made cautiously. Moreover, placebo effects, expectancy effects, and the natural course of the disease may influence outcomes. Future research should consider controlled trials to ascertain the efficacy and safety of such interventions in diverse settings.

Keywords: home treatment; palliative care; psychedelic; psychedelic‐assisted therapy; throat cancer.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. By declaring no competing interests, the authors affirm that their research findings and interpretations are presented without any undue influence from personal or financial relationships.

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