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Review
. 2024 Aug 6:11:1419229.
doi: 10.3389/fnut.2024.1419229. eCollection 2024.

Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle

Colleen S Deane #  1 , Jake Cox #  2 , Philip J Atherton  2   3
Affiliations
Review

Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle

Colleen S Deane et al. Front Nutr. .

Abstract

Protein nutrition is critical for the maintenance of skeletal muscle mass across the lifecourse and for the growth of muscle in response to resistance exercise - both acting via the stimulation of protein synthesis. The transient anabolic response to protein feeding may vary in magnitude and duration, depending on, e.g., timing, dose, amino acid composition and delivery mode, which are in turn influenced by physical activity and age. This review aims to: (i) summarise the fundamental metabolic responses of muscle to protein feeding, (ii) discuss key variables regulating muscle anabolic responses to protein feeding, and (iii) explore how these variables can be optimised for muscle anabolism in response to physical activity and ageing.

Keywords: ageing; exercise; muscle; nutrition; protein.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

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Variables regulating age-related anabolic responses to protein nutrition in skeletal muscle.
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Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was also supported by the Medical Research Council, United Kingdom (grant no. MR/P021220/1) as part of the MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research awarded to the Universities of Nottingham and Birmingham, and the National Institute for Health Research, United Kingdom, Nottingham Biomedical Research Centre.

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