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Link to original content: http://pubmed.ncbi.nlm.nih.gov/39159129/
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Review
. 2024 Aug 18;16(16):12073-12100.
doi: 10.18632/aging.206078. Epub 2024 Aug 18.

Targeting multiple hallmarks of mammalian aging with combinations of interventions

Alexander Y Panchin  1 , Anna Ogmen  2   3 , Artem S Blagodatski  4 , Anastasia Egorova  2 , Mikhail Batin  2 , Timofey Glinin  2   5
Affiliations
Review

Targeting multiple hallmarks of mammalian aging with combinations of interventions

Alexander Y Panchin et al. Aging (Albany NY). .

Abstract

Aging is currently viewed as a result of multiple biological processes that manifest themselves independently, reinforce each other and in their totality lead to the aged phenotype. Genetic and pharmaceutical approaches targeting specific underlying causes of aging have been used to extend the lifespan and healthspan of model organisms ranging from yeast to mammals. However, most interventions display only a modest benefit. This outcome is to be expected if we consider that even if one aging process is successfully treated, other aging pathways may remain intact. Hence solving the problem of aging may require targeting not one but many of its underlying causes at once. Here we review the challenges and successes of combination therapies aimed at increasing the lifespan of mammals and propose novel directions for their development. We conclude that both additive and synergistic effects on mammalian lifespan can be achieved by combining interventions that target the same or different hallmarks of aging. However, the number of studies in which multiple hallmarks were targeted simultaneously is surprisingly limited. We argue that this approach is as promising as it is understudied.

Keywords: aging; combination therapy; hallmarks; lifespan and healthspan; mouse; synergistic effect.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare no conflicts of interest related to this study.

Figures

Figure 1
Figure 1
Possible strategies of development of aging combination therapies. This figure illustrates the various hallmarks of aging that could be addressed by different existing interventions. Additionally, it proposes four example combinations of therapies, each detailing which specific treatment targets a particular hallmark of aging.
See this image and copyright information in PMC

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