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Link to original content: http://pubmed.ncbi.nlm.nih.gov/39120268/
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Review
. 2024 Jul 23;13(15):1236.
doi: 10.3390/cells13151236.

Unraveling the Dynamics of Estrogen and Progesterone Signaling in the Endometrium: An Overview

Isabelle Dias Da Silva  1 , Vincent Wuidar  1 , Manon Zielonka  1 , Christel Pequeux  1
Affiliations
Review

Unraveling the Dynamics of Estrogen and Progesterone Signaling in the Endometrium: An Overview

Isabelle Dias Da Silva et al. Cells. .

Abstract

The endometrium is crucial for the perpetuation of human species. It is a complex and dynamic tissue lining the inner wall of the uterus, regulated throughout a woman's life based on estrogen and progesterone fluctuations. During each menstrual cycle, this multicellular tissue undergoes cyclical changes, including regeneration, differentiation in order to allow egg implantation and embryo development, or shedding of the functional layer in the absence of pregnancy. The biology of the endometrium relies on paracrine interactions between epithelial and stromal cells involving complex signaling pathways that are modulated by the variations of estrogen and progesterone levels across the menstrual cycle. Understanding the complexity of estrogen and progesterone receptor signaling will help elucidate the mechanisms underlying normal reproductive physiology and provide fundamental knowledge contributing to a better understanding of the consequences of hormonal imbalances on gynecological conditions and tumorigenesis. In this narrative review, we delve into the physiology of the endometrium, encompassing the complex signaling pathways of estrogen and progesterone.

Keywords: endometrium; estrogen receptor; progesterone receptor; progestogen; signaling pathway; transcription factor.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Estrogen levels throughout woman’s life, adapted from [8,9]. Created with BioRender.com (accessed on 16 June 2024).
Figure 2
Figure 2
Woman’s menstrual cycle according to estrogen and progesterone fluctuation levels. Created with BioRender.com (accessed on 16 June 2024).
Figure 3
Figure 3
ER Signaling in response to estrogens during proliferative phase. Created with BioRender.com (accessed on 16 June 2024).
Figure 4
Figure 4
PR signaling in response to progesterone during secretory phase. Created with BioRender.com (accessed on 19 June 2024).
See this image and copyright information in PMC

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References

    1. Zacur H.A. Hormonal Changes Throughout Life in Women. Headache J. Head Face Pain. 2006;46:S50–S55. doi: 10.1111/j.1526-4610.2006.00554.x. - DOI - PubMed
    1. Soares C.N. Taking a Fresh Look at Mood, Hormones, and Menopause. Menopause. 2020;27:371–373. doi: 10.1097/GME.0000000000001506. - DOI - PubMed
    1. Rosenfield R.L., Lipton R.B., Drum M.L. Thelarche, Pubarche, and Menarche Attainment in Children with Normal and Elevated Body Mass Index. Pediatrics. 2009;123:84–88. doi: 10.1542/peds.2008-0146. - DOI - PubMed
    1. Mihm M., Gangooly S., Muttukrishna S. The Normal Menstrual Cycle in Women. Anim. Reprod. Sci. 2011;124:229–236. doi: 10.1016/j.anireprosci.2010.08.030. - DOI - PubMed
    1. Cha J., Sun X., Dey S.K. Mechanisms of Implantation: Strategies for Successful Pregnancy. Nat. Med. 2012;18:1754. doi: 10.1038/nm.3012. - DOI - PMC - PubMed

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