Neuroplasticity in Parkinson's disease

doi:10.1007/s00702-024-02813-y

Review

. 2024 Nov;131(11):1329-1339.

doi: 10.1007/s00702-024-02813-y. Epub 2024 Aug 5.

Neuroplasticity in Parkinson's disease

Bogdan Ovidiu Popescu^{1

2}, Lucia Batzu^{3

4}, Pedro J Garcia Ruiz⁵, Delia Tulbă⁶, Elena Moro⁷, Patrick Santens^{8

9}

Affiliations

¹ Department of Clinical Neurosciences, 'Carol Davila' University of Medicine and Pharmacy Bucharest, Bucharest, Romania. bogdan.popescu@umfcd.ro.
² Laboratory of Cell Biology, Neurosciences and Experimental Myology, 'Victor Babeș' National Institute of Pathology, Bucharest, Romania. bogdan.popescu@umfcd.ro.
³ Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.
⁴ Parkinson's Foundation Centre of Excellence, King's College Hospital, London, UK.
⁵ Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain.
⁶ Department of Clinical Neurosciences, 'Carol Davila' University of Medicine and Pharmacy Bucharest, Bucharest, Romania.
⁷ Division of Neurology, Centre Hospitalier Universitaire de Grenoble, Grenoble Alpes University, Grenoble Institute of Neuroscience, INSERM U1216, Grenoble, France.
⁸ Department of Neurology, University Hospital Ghent, Ghent, Belgium.
⁹ Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

PMID: 39102007
PMCID: PMC11502561
DOI: 10.1007/s00702-024-02813-y

Review

Neuroplasticity in Parkinson's disease

Bogdan Ovidiu Popescu et al. J Neural Transm (Vienna). 2024 Nov.

. 2024 Nov;131(11):1329-1339.

doi: 10.1007/s00702-024-02813-y. Epub 2024 Aug 5.

Authors

Bogdan Ovidiu Popescu^{1

2}, Lucia Batzu^{3

4}, Pedro J Garcia Ruiz⁵, Delia Tulbă⁶, Elena Moro⁷, Patrick Santens^{8

9}

Affiliations

¹ Department of Clinical Neurosciences, 'Carol Davila' University of Medicine and Pharmacy Bucharest, Bucharest, Romania. bogdan.popescu@umfcd.ro.
² Laboratory of Cell Biology, Neurosciences and Experimental Myology, 'Victor Babeș' National Institute of Pathology, Bucharest, Romania. bogdan.popescu@umfcd.ro.
³ Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.
⁴ Parkinson's Foundation Centre of Excellence, King's College Hospital, London, UK.
⁵ Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain.
⁶ Department of Clinical Neurosciences, 'Carol Davila' University of Medicine and Pharmacy Bucharest, Bucharest, Romania.
⁷ Division of Neurology, Centre Hospitalier Universitaire de Grenoble, Grenoble Alpes University, Grenoble Institute of Neuroscience, INSERM U1216, Grenoble, France.
⁸ Department of Neurology, University Hospital Ghent, Ghent, Belgium.
⁹ Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

PMID: 39102007
PMCID: PMC11502561
DOI: 10.1007/s00702-024-02813-y

Abstract

Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, affecting millions of people and rapidly increasing over the last decades. Even though there is no intervention yet to stop the neurodegenerative pathology, many efficient treatment methods are available, including for patients with advanced PD. Neuroplasticity is a fundamental property of the human brain to adapt both to external changes and internal insults and pathological processes. In this paper we examine the current knowledge and concepts concerning changes at network level, cellular level and molecular level as parts of the neuroplastic response to protein aggregation pathology, synapse loss and neuronal loss in PD. We analyse the beneficial, compensatory effects, such as augmentation of nigral neurons efficacy, as well as negative, maladaptive effects, such as levodopa-induced dyskinesia. Effects of physical activity and different treatments on neuroplasticity are considered and the opportunity of biomarkers identification and use is discussed.

Keywords: AMPA; BDNF; Biomarkers; Dopamine; NMDA; Neuroplasticity; Parkinson’s disease.

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References

1. Agosta F, Gatti R, Sarasso E, Volonté MA, Canu E, Meani A, Sarro L, Copetti M, Cattrysse E, Kerckhofs E, Comi G, Falini A, Filippi M (2017) Brain plasticity in Parkinson’s disease with freezing of gait induced by action observation training. J Neurol 264(1):88–101. 10.1007/s00415-016-8309-7 - PubMed
1. Ahlskog JE (2011) Does vigorous exercise have a neuroprotective effect in Parkinson disease? Neurology 77(3):288–294. 10.1212/WNL.0b013e318225ab66 - PMC - PubMed
1. Ahlskog JE (2018) Aerobic exercise: evidence for a direct brain effect to slow parkinson disease progression. Mayo Clin Proc 93(3):360–372. 10.1016/j.mayocp.2017.12.015 - PubMed
1. Albin RL, Leventhal DK (2017) The missing, the short, and the long: Levodopa responses and dopamine actions. Ann Neurol 82(1):4–19. 10.1002/ana.24961 - PMC - PubMed
1. Anderson RW, Farokhniaee A, Gunalan K, Howell B, McIntyre CC (2018) Action potential initiation, propagation, and cortical invasion in the hyperdirect pathway during subthalamic deep brain stimulation. Brain Stimul 11(5):1140–1150. 10.1016/j.brs.2018.05.008 - PMC - PubMed

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[1] Agosta F, Gatti R, Sarasso E, Volonté MA, Canu E, Meani A, Sarro L, Copetti M, Cattrysse E, Kerckhofs E, Comi G, Falini A, Filippi M (2017) Brain plasticity in Parkinson’s disease with freezing of gait induced by action observation training. J Neurol 264(1):88–101. 10.1007/s00415-016-8309-7 - PubMed

[2] Agosta F, Gatti R, Sarasso E, Volonté MA, Canu E, Meani A, Sarro L, Copetti M, Cattrysse E, Kerckhofs E, Comi G, Falini A, Filippi M (2017) Brain plasticity in Parkinson’s disease with freezing of gait induced by action observation training. J Neurol 264(1):88–101. 10.1007/s00415-016-8309-7 - PubMed

[3] Ahlskog JE (2011) Does vigorous exercise have a neuroprotective effect in Parkinson disease? Neurology 77(3):288–294. 10.1212/WNL.0b013e318225ab66 - PMC - PubMed

[4] Ahlskog JE (2011) Does vigorous exercise have a neuroprotective effect in Parkinson disease? Neurology 77(3):288–294. 10.1212/WNL.0b013e318225ab66 - PMC - PubMed

[5] Ahlskog JE (2018) Aerobic exercise: evidence for a direct brain effect to slow parkinson disease progression. Mayo Clin Proc 93(3):360–372. 10.1016/j.mayocp.2017.12.015 - PubMed

[6] Ahlskog JE (2018) Aerobic exercise: evidence for a direct brain effect to slow parkinson disease progression. Mayo Clin Proc 93(3):360–372. 10.1016/j.mayocp.2017.12.015 - PubMed

[7] Albin RL, Leventhal DK (2017) The missing, the short, and the long: Levodopa responses and dopamine actions. Ann Neurol 82(1):4–19. 10.1002/ana.24961 - PMC - PubMed

[8] Albin RL, Leventhal DK (2017) The missing, the short, and the long: Levodopa responses and dopamine actions. Ann Neurol 82(1):4–19. 10.1002/ana.24961 - PMC - PubMed

[9] Anderson RW, Farokhniaee A, Gunalan K, Howell B, McIntyre CC (2018) Action potential initiation, propagation, and cortical invasion in the hyperdirect pathway during subthalamic deep brain stimulation. Brain Stimul 11(5):1140–1150. 10.1016/j.brs.2018.05.008 - PMC - PubMed

[10] Anderson RW, Farokhniaee A, Gunalan K, Howell B, McIntyre CC (2018) Action potential initiation, propagation, and cortical invasion in the hyperdirect pathway during subthalamic deep brain stimulation. Brain Stimul 11(5):1140–1150. 10.1016/j.brs.2018.05.008 - PMC - PubMed

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Neuroplasticity in Parkinson's disease

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Neuroplasticity in Parkinson's disease

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