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The Impact of Cornelian Cherry (Cornus mas L.) on Cardiometabolic Risk Factors: A Meta-Analysis of Randomised Controlled Trials - PubMed Skip to main page content
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Meta-Analysis
. 2024 Jul 8;16(13):2173.
doi: 10.3390/nu16132173.

The Impact of Cornelian Cherry (Cornus mas L.) on Cardiometabolic Risk Factors: A Meta-Analysis of Randomised Controlled Trials

Oleg Frumuzachi  1   2 , Helena Kieserling  2 , Sascha Rohn  2 , Andrei Mocan  3 , Gianina Crișan  1
Affiliations
Meta-Analysis

The Impact of Cornelian Cherry (Cornus mas L.) on Cardiometabolic Risk Factors: A Meta-Analysis of Randomised Controlled Trials

Oleg Frumuzachi et al. Nutrients. .

Abstract

This meta-analysis aimed to summarise clinical evidence regarding the effect of supplementation with cornelian cherry (Cornus mas L.) on different cardiometabolic outcomes. An extensive literature survey was carried out until 10 April 2024. A total of 415 participants from six eligible studies were included. The overall results from the random-effects model indicated that cornelian cherry supplementation significantly reduced body weight (standardised mean difference [SMD] = -0.27, confidence interval [CI]: -0.52, -0.02, p = 0.03), body mass index (SMD = -0.42, CI: -0.73, -0.12, p = 0.007), fasting blood glucose (SMD = -0.46, CI: -0.74, -0.18, p = 0.001), glycated haemoglobin (SMD = -0.70, CI: -1.19, -0.22, p = 0.005), and HOMA-IR (SMD = -0.89, CI: -1.62, -0.16, p = 0.02), while high-density lipoprotein cholesterol significantly increased (SMD = 0.38, CI: 0.10, 0.65, p = 0.007). A sensitivity analysis showed that cornelian cherry supplementation significantly reduced total plasma triglycerides, total cholesterol, low-density lipoprotein cholesterol, and insulin levels. Cornelian cherry supplementation did not significantly affect waist circumference and liver parameters among the participants. Considering these findings, this meta-analysis indicates that supplementation with cornelian cherry may impact diverse cardiometabolic risk factors among individuals considered to be at a high risk.

Keywords: anthocyanins; glucose metabolism; lipid profile; metabolic disease; weight loss.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The PRISMA flowchart depicting the study selection process.
Figure 2
Figure 2
The evaluation of risk of bias concerning each aspect across the studies included in the meta-analysis. D1—randomisation process, D2—deviations from intended interventions, D3—missing outcome data, D4—measurement of the outcome, and D5—selection of the reported results [28,29,30,31,32,33].
Figure 3
Figure 3
Risk of bias across individual elements, presented as percentage (intention-to-treat), for studies included in the meta-analysis.
Figure 4
Figure 4
Forest plot representation of RCTs exploring the impact of cornelian cherry supplementation on anthropometric measurements ((A): body weight, (B): BMI, and (C): waist circumference) [28,29,30,32,33].
Figure 5
Figure 5
Forest plot representation of RCTs exploring the impact of cornelian cherry supplementation on blood lipid levels ((A): total triglycerides, (B): total cholesterol, (C): LDL-C, and (D): HDL-C) [28,29,30,33].
Figure 6
Figure 6
Forest plot representation of RCTs exploring the impact of cornelian cherry supplementation on glycaemic parameters ((A): fasting blood glucose, (B): insulin, (C): HbA1c, and (D): HOMA-IR) [28,29,30,33].
Figure 7
Figure 7
Forest plot representation of RCTs exploring the impact of cornelian cherry supplementation on liver parameters ((A): AST and (B): ALT) [28,29,31].
See this image and copyright information in PMC

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References

    1. Qorbani M., Mahdavi-Gorabi A., Khatibi N., Ejtahed H.S., Khazdouz M., Djalalinia S., Sahebkar A., Esmaeili-Abdar M., Hasani M. Dietary diversity score and cardio-metabolic risk factors: An updated systematic review and meta-analysis. Eat. Weight Disord. 2022;27:85–100. doi: 10.1007/s40519-020-01090-4. - DOI - PubMed
    1. Sattar N., Forrest E., Preiss D. Non-alcoholic fatty liver disease. BMJ. 2014;349:g4596. doi: 10.1136/bmj.g4596. - DOI - PMC - PubMed
    1. Lan Q., Zhang Y., Lin F., Meng Q., Buys N.J., Fan H., Sun J. Association between serum aminotransferases and risk of new-onset cardiometabolic disease in a healthy chinese population: A cohort study. Front. Public Health. 2022;10:902393. doi: 10.3389/fpubh.2022.902393. - DOI - PMC - PubMed
    1. Porter S.A., Pedley A., Massaro J.M., Vasan R.S., Hoffmann U., Fox C.S. Aminotransferase levels are associated with cardiometabolic risk above and beyond visceral fat and insulin resistance: The Framingham Heart Study. Arterioscler. Thromb. Vasc. Biol. 2013;33:139–146. doi: 10.1161/ATVBAHA.112.300075. - DOI - PMC - PubMed
    1. Lavie C.J., Ozemek C., Carbone S., Katzmarzyk P.T., Blair S.N. Sedentary behavior, Exercise, and Cardiovascular Health. Circ. Res. 2019;124:799–815. doi: 10.1161/CIRCRESAHA.118.312669. - DOI - PubMed

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