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Link to original content: http://pubmed.ncbi.nlm.nih.gov/38962719/
Bacterial therapies at the interface of synthetic biology and nanomedicine - PubMed Skip to main page content
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. 2024 Feb;2(2):120-135.
doi: 10.1038/s44222-023-00119-4. Epub 2023 Oct 10.

Bacterial therapies at the interface of synthetic biology and nanomedicine

Jaeseung Hahn  1 , Suwan Ding  1 , Jongwon Im  1 , Tetsuhiro Harimoto  1 , Kam W Leong  1   2 , Tal Danino  1   3   4
Affiliations

Bacterial therapies at the interface of synthetic biology and nanomedicine

Jaeseung Hahn et al. Nat Rev Bioeng. 2024 Feb.

Abstract

Bacteria are emerging as living drugs to treat a broad range of disease indications. However, the inherent advantages of these replicating and immunostimulatory therapies also carry the potential for toxicity. Advances in synthetic biology and the integration of nanomedicine can address this challenge through the engineering of controllable systems that regulate spatial and temporal activation for improved safety and efficacy. Here, we review recent progress in nanobiotechnology-driven engineering of bacteria-based therapies, highlighting limitations and opportunities that will facilitate clinical translation.

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Conflict of interest statement

Competing interests The authors declare no competing interests.

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