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Link to original content: http://pubmed.ncbi.nlm.nih.gov/38849981/
Topological differences of striato-thalamo-cortical circuit in functional brain network between premature ejaculation patients with and without depression - PubMed Skip to main page content
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. 2024 Jun;14(6):e3585.
doi: 10.1002/brb3.3585.

Topological differences of striato-thalamo-cortical circuit in functional brain network between premature ejaculation patients with and without depression

Xinyue Zhang  1 , Peining Niu  2 , Mengqing Su  3 , Li Zhou  3 , Yunke Huang  4 , Jianhuai Chen  5 , Shaowei Liu  6
Affiliations

Topological differences of striato-thalamo-cortical circuit in functional brain network between premature ejaculation patients with and without depression

Xinyue Zhang et al. Brain Behav. 2024 Jun.

Abstract

Introduction: Premature ejaculation (PE), a common male sexual dysfunction, often accompanies by abnormal psychological factors, such as depression. Recent neuroimaging studies have revealed structural and functional brain abnormalities in PE patients. However, there is limited neurological evidence supporting the comorbidity of PE and depression. This study aimed to explore the topological changes of the functional brain networks of PE patients with depression.

Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 60 PE patients (30 with depression and 30 without depression) and 29 healthy controls (HCs). Functional brain networks were constructed for all participants based on rs-fMRI data. The nodal parameters including nodal centrality and efficiency were calculated by the method of graph theory analysis and then compared between groups. In addition, the results were corrected for multiple comparisons by family-wise error (FWE) (p < .05).

Results: PE patients with depression had increased degree centrality and global efficiency in the right pallidum, as well as increased degree centrality in the right thalamus when compared with HCs. PE patients without depression showed increased degree centrality in the right pallidum and thalamus, as well as increased global efficiency in the right precuneus, pallidum, and thalamus when compared with HCs. PE patients with depression demonstrated decreased degree centrality in the right pallidum and thalamus, as well as decreased global efficiency in the right precuneus, pallidum, and thalamus when compared to those without depression. All the brain regions above survived the FWE correction.

Conclusion: The results suggested that increased and decreased functional connectivity, as well as the capability of global integration of information in the brain, might be related to the occurrence of PE and the comorbidity depression in PE patients, respectively. These findings provided new insights into the understanding of the pathological mechanisms underlying PE and those with depression.

Keywords: brain network; depression; graph theoretical analysis; premature ejaculation; resting‐state functional magnetic resonance imaging.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
The small‐worldness characteristics of the brain networks. Small‐worldness index σ plotted for network sparsity ranging from 0.05 to 0.4. PE: premature ejaculation; HC: health controls.
FIGURE 2
FIGURE 2
Comparison of nodal parameters between groups. Multigroup comparisons were carried out by one‐way analysis of variance (ANOVA) test with post hoc contrasts by least‐significant difference (LSD) test. *indicated significant differences between two premature ejaculation (PE) groups; #indicated significant differences between PE without depression and health controls (HCs). △indicated significant differences between PE with depression and HCs. In order to account for the multiple comparisons, a family‐wise error (FWE) correction was applied to the initial p‐value of .05.
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