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Link to original content: http://pubmed.ncbi.nlm.nih.gov/38724126/
Psychedelics and Evidence-based Psychotherapy: A Systematic Review with Recommendations for Advancing Psychedelic Therapy Research - PubMed Skip to main page content
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Review
. 2024 Jun;47(2):367-398.
doi: 10.1016/j.psc.2024.02.006. Epub 2024 Mar 19.

Psychedelics and Evidence-based Psychotherapy: A Systematic Review with Recommendations for Advancing Psychedelic Therapy Research

Lewis Leone  1 , Bryan McSpadden  1 , Annamarie DeMarco  2 , Lauren Enten  2 , Rachel Kline  2 , Gregory A Fonzo  3
Affiliations
Review

Psychedelics and Evidence-based Psychotherapy: A Systematic Review with Recommendations for Advancing Psychedelic Therapy Research

Lewis Leone et al. Psychiatr Clin North Am. 2024 Jun.

Abstract

Administration of psychedelics for mental health treatment, typically referred to as "psychedelic-assisted therapy," is a broad term with a very heterogeneous implementation. Despite increasing interest in the clinical application of psychedelic compounds for psychiatric disorders, there is no consensus on how to best integrate the psychedelic experience with evidence-based psychotherapeutic treatment. This systematic review provides a timely appraisal of existing approaches to combining psychotherapy with psychedelics and provides clear recommendations to best develop, optimize, and integrate evidence-based psychotherapy with psychedelic administration for straightforward scientific inference and maximal therapeutic benefit.

Keywords: Evidence-based treatment; Psychedelic-assisted therapy; Psychedelics; Treatment development.

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Conflict of interest statement

Disclosure Dr. G A. Fonzo has received monetary compensation for consulting work with SynapseBio AI, and he owns equity in Alto Neuroscience. Neither of these activities are related to the content of this work. All of the other authors report no commercial or financial conflicts of interest.

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