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Link to original content: http://pubmed.ncbi.nlm.nih.gov/38314303/
Severe Jarisch-Herxheimer Reaction (JHR) in a leptospirosis patient: A case report - PubMed Skip to main page content
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Case Reports
. 2024 Jan 13;10(3):e24538.
doi: 10.1016/j.heliyon.2024.e24538. eCollection 2024 Feb 15.

Severe Jarisch-Herxheimer Reaction (JHR) in a leptospirosis patient: A case report

Ruo-Yan Zhao  1   2 , Meng-Die Liu  3   2 , Ying-Xin Lin  2 , Lei Huang  2
Affiliations
Case Reports

Severe Jarisch-Herxheimer Reaction (JHR) in a leptospirosis patient: A case report

Ruo-Yan Zhao et al. Heliyon. .

Abstract

Leptospirosis is a zoonosis that is related to potential respiratory, renal, neurological, and cardiovascular failure. At present, antibiotics are the recommended treatment, but due to the underlying cause of the disease, they may induce the Jarisch-Herxheimer reaction (JHR) within 24 hours. At the same time, we speculate that JHR may aggravate the natural course of leptospirosis. Considering that there are few available reports on this event, we will share a case of pulmonary hemorrhagic leptospirosis, where antibiotic treatment is suspected to have triggered the JHR. This report is expected to improve clinical attention to the relationship between leptospirosis and JHR.

Keywords: Acute renal failure; Acute respiratory distress syndrome; Case report; Jarisch-Herxheimer reaction; Leptospirosis.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Chest high-resolution CT images on admission. Both lungs are scattered with exudative lesions (At the red arrow）. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2
Fig. 2
Chest X-ray captured on the first day of admission.
Fig. 3
Fig. 3
Chest X-ray captured on the tenth day of admission.
Fig. 4
Fig. 4
Chest high-resolution CT images at follow-up. The exudate foci in the lungs are basically absorbed and disappear.
See this image and copyright information in PMC

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References

    1. Dhakal A., Sbar E. StatPearls Publishing; Treasure Island (FL: 2023. Jarisch-Herxheimer Reaction. - PubMed
    1. Maier A., Kaeser R., Thimme R., Boettler T. Acute pancreatitis and vasoplegic shock associated with leptospirosis - a case report and review of the literature. BMC Infect. Dis. 2019;19(1):395. doi: 10.1186/s12879-019-4040-1. - DOI - PMC - PubMed
    1. Pothuri P., Ahuja K., Kumar V., Lal S., Tumarinson T., Mahmood K. Leptospirosis presenting with rapidly progressing acute renal failure and conjugated hyperbilirubinemia: a case report. Am J Case Rep. 2016;17:567–569. - PMC - PubMed
    1. Kupferman T., Coffee M.P., Eckhardt B.J. Case report: a cluster of three leptospirosis cases in a New York city abattoir and an unusual complication in the index case. Am. J. Trop. Med. Hyg. 2017;97(6):1679–1681. doi: 10.4269/ajtmh.17-0545. - DOI - PMC - PubMed
    1. Wang H.J., Chen G.Z., Zhou C.J., Fu Y., Yao L.N. Veno-venous extracorporeal membrane oxygenation successfully treated a case of severe pulmonary hemorrhage caused by leptospirosis. BMC Infect. Dis. 2020;20(1):794. doi: 10.1186/s12879-020-05518-1. - DOI - PMC - PubMed

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