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Link to original content: http://pubmed.ncbi.nlm.nih.gov/37456624/
Physical activity and sleep relate to antibody maintenance following naturalistic infection and/or vaccination in older adults - PubMed Skip to main page content
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. 2023 Jun 25:32:100661.
doi: 10.1016/j.bbih.2023.100661. eCollection 2023 Oct.

Physical activity and sleep relate to antibody maintenance following naturalistic infection and/or vaccination in older adults

Anna C Whittaker  1 , Len De Nys  1 , Ryan C Brindle  2 , Mark T Drayson  3
Affiliations

Physical activity and sleep relate to antibody maintenance following naturalistic infection and/or vaccination in older adults

Anna C Whittaker et al. Brain Behav Immun Health. .

Abstract

Health behaviours such as being physically active and having good quality sleep have been associated with decreased susceptibility to infection and stronger antibody responses to vaccination. Less is known about how such factors might influence the maintenance of immunity following naturalistic infection and/or prior vaccination, particularly among older adults who may have formed initial antibodies some time ago. This analysis explored antibody levels against a range of common infectious diseases in 104 older adults (60 women) aged 65+ years, and whether these relate to self-reported physical activity (PA) and sleep. PA and sleep were measured subjectively through standardized questions. Antibody levels to a range of common pathogens, including pneumococcal (Pn) and meningococcal (Men) serotypes, Haemophilus influenza type b, diphtheria, and tetanus were assayed using Multiplex technology. Higher PA at baseline related to higher antibody levels against three Pn serotypes and MenY, and higher PA at one month with higher levels against six Pn serotypes. Longer time in bed related to higher antibody levels against Pn4, and longer sleep related to higher levels against Pn19f. More difficulty staying awake in the day related to lower antibodies against Pn19a, Pn19f, MenA and MenY, and more frequent daytime napping related to lower levels against three Pn serotypes and MenY. Using clinically protective antibody thresholds as an outcome showed similar results for PA, but effects for sleep became non-significant, with the exception of time in bed. This extends beyond existing literature demonstrating associations between PA and sleep and peak antibody response to vaccination to antibody maintenance. Longitudinal research with objective measures of health behaviours is warranted.

Keywords: Antibodies; Naturalistic immunity; Physical activity; Sleep; Vaccination; ageing.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Differences in PA score at baseline between those with seroprotection and those not protected against MenY (n = 90).
Fig. 2
Fig. 2
Differences in PA score at one month between those with seroprotection and those not protected against Pn serotypes (n = 98).
Fig. 3
Fig. 3
Differences in time in bed between those with sero-protection and those not protected (n = 104).
See this image and copyright information in PMC

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