iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: http://pubmed.ncbi.nlm.nih.gov/37299569/
The Potential of Natural Oils to Improve Inflammatory Bowel Disease - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun 1;15(11):2606.
doi: 10.3390/nu15112606.

The Potential of Natural Oils to Improve Inflammatory Bowel Disease

Yaxi Zhou  1   2 , Diandian Wang  1   2 , Hao Duan  1   2 , Shiqi Zhou  1   2 , Jinhong Guo  1   2 , Wenjie Yan  1   2
Affiliations
Review

The Potential of Natural Oils to Improve Inflammatory Bowel Disease

Yaxi Zhou et al. Nutrients. .

Abstract

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder that includes ulcerative colitis (UC) and Crohn's disease (CD), the exact cause of which is still unknown. Numerous studies have confirmed that diet is one of the major environmental factors associated with IBD, as it can regulate the gut microbiota and reduce inflammation and oxidative stress. Since the consumption of oil is essential in the diet, improving IBD through oil has potential. In this article, we first briefly reviewed the current treatment methods for IBD and introduce the role of natural oils in improving inflammatory diseases. We then focused on the recent discovery of the role of natural oils in the prevention and treatment of IBD and summarized their main mechanisms of action. The results showed that the anti-inflammatory activity of oils derived from different plants and animals has been validated in various experimental animal models. These oils are capable of improving the intestinal homeostasis in IBD animal models through multiple mechanisms, including modulation of the gut microbiota, protection of the intestinal barrier, reduction in colonic inflammation, improvement in oxidative stress levels in the intestine, and regulation of immune homeostasis. Therefore, dietary or topical use of natural oils may have potential therapeutic effects on IBD. However, currently, only a few clinical trials support the aforementioned conclusions. This review emphasized the positive effects of natural oils on IBD and encouraged more clinical trials to provide more reliable evidence on the improvement of human IBD by natural oils as functional substances.

Keywords: inflammatory bowel disease; mechanisms of action; natural oil; therapeutic drugs.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Current therapeutic drugs and methods for IBD. The content highlighted in red font indicates the limitations of the method.
Figure 2
Figure 2
Natural oils regulate the intestinal microbiota and improve the intestinal barrier mechanism (By Figdraw.).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Aufses A.H., Jr. The History of Crohn’s Disease. Surg. Clin. 2001;81:1–11. doi: 10.1016/S0039-6109(05)70270-X. - DOI - PubMed
    1. Mulder D.J., Noble A.J., Justinich C.J., Duffin J.M. A tale of two diseases: The history of inflammatory bowel disease. J. Crohn’s Colitis. 2014;8:341–348. doi: 10.1016/j.crohns.2013.09.009. - DOI - PubMed
    1. Niu W., Chen X., Xu R., Dong H., Yang F., Wang Y., Zhang Z., Ju J. Polysaccharides from natural resources exhibit great potential in the treatment of ulcerative colitis: A review. Carbohydr. Polym. 2021;254:117189. doi: 10.1016/j.carbpol.2020.117189. - DOI - PubMed
    1. Ramos G.P., Papadakis K.A. Mechanisms of Disease: Inflammatory Bowel Diseases. Mayo Clin. Proc. 2019;94:155–165. doi: 10.1016/j.mayocp.2018.09.013. - DOI - PMC - PubMed
    1. Hodson R. Inflammatory bowel disease. Nature. 2016;540:S97. doi: 10.1038/540S97a. - DOI - PubMed