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Link to original content: http://pubmed.ncbi.nlm.nih.gov/37127791/
The interplay between bicarbonate kinetics and gastrointestinal upset on ergogenic potential after sodium bicarbonate intake: a randomized double-blind placebo-controlled trial - PubMed Skip to main page content
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Randomized Controlled Trial
. 2023 May 1;13(1):7081.
doi: 10.1038/s41598-023-34343-0.

The interplay between bicarbonate kinetics and gastrointestinal upset on ergogenic potential after sodium bicarbonate intake: a randomized double-blind placebo-controlled trial

Krzysztof Durkalec-Michalski  1   2 , Paulina M Nowaczyk  3 , Joanna Kamińska  4 , Bryan Saunders  5   6 , Igor Łoniewski  7 , Dominika Czubaszek  3 , Michal Steffl  8 , Tomasz Podgórski  4
Affiliations
Randomized Controlled Trial

The interplay between bicarbonate kinetics and gastrointestinal upset on ergogenic potential after sodium bicarbonate intake: a randomized double-blind placebo-controlled trial

Krzysztof Durkalec-Michalski et al. Sci Rep. .

Abstract

This double-blind placebo-controlled cross-over study utilized comprehensive monitoring of blood bicarbonate (HCO3¯) kinetics and evaluation of gastrointestinal (GI) upset to determine their impact on an ergogenic potential of sodium bicarbonate (SB) co-ingested with carbohydrate (CHO). Nineteen CrossFit athletes performed 6 bouts of 15 s Wingate Anaerobic Test (WAnT) 90 min post-ingestion of 0.4 g·kg-1 body mass (BM) of SB (SB + CHO treatment) or PLA (PLA + CHO treatment) with 15 g CHO. Blood HCO3¯ concentration was evaluated at baseline, 30-, 60-, 75- and 90 min post-ingestion, in between WAnT bouts, and 3 and 45 min post-exercise, while GI upset at 120 min after protocol started. Control (no supplementation; CTRL) procedures were also performed. An effective elevation of extra-cellular buffering capacity was observed 60-90 min post-ingestion of SB + CHO. At mean peak blood HCO3¯, or at start of exercise an increase > 6 mmol·L-1 in HCO3¯ was noted in 84% and 52.6% participants, respectively. SB + CHO did not prevent performance decrements in WAnT bouts. There were no significant relationships between changes in blood HCO3¯ and WAnTs' performance. Total GI was significantly higher in SB + CHO compared to CTRL, and stomach problems in SB + CHO compared to CTRL and PLA + CHO. There were inverse associations between peak- (p = 0.031; r = - 0.495), average- (p = 0.002; r = - 0.674) and minimum power (p = 0.008; r = - 0.585) and total GI upset, as well as average power and severe GI distress (p = 0.042; r = - 0.471) at SB + CHO. The implemented dose of SB + CHO was effective in improving buffering capacity, but did not prevent decrements in WAnTs' performance. GI side effects were crucial in affecting the ergogenic potential of SB and thus must be insightfully monitored in future studies.

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Conflict of interest statement

I.Ł. is a shareholder of an alkali products distributor and has received honoraria from the Sanum Polska sp. z o. o. However, the content of this study was not constrained by this fact in absolutely no extend. K.D.-M., P.M.N., J.K., B.S., D.C., M.S., and T.P. report no conflicts of interest. The results of the present study do not constitute endorsement by the Scientific Reports. The authors declare that the results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation.

Figures

Figure 1
Figure 1
Mean and individual (light-colour lines) blood bicarbonate (A), pH (B), lactate (C) values. Data are expressed as means (square), 95% CI (box), 95% CI + SD (whisker), raw data (light-colour lines). a,b,cDifferent lowercased letters refers to significant differences between study conditions (CTRL, SB + CHO, PLA + CHO); A–Gdifferent uppercased letters refers to significant differences between measuring time points (from − 90′EX to + 45′EX) within SB + CHO condition.
Figure 2
Figure 2
∆ of mean and individual (light-colour line) bicarbonate changes between baseline (pre-ingestion) and 30, 60, 75 and 90 min after SB + CHO or PLA + CHO intake or the first blood drawn (CTRL). Data are expressed as means (square), 95% CI (box), 95%CI + SD (whisker), raw data (light-colour lines). A–CDifferent uppercased letters refers to significant differences between measuring time points (from − 90′EX to + 45′EX) within SB + CHO condition.
Figure 3
Figure 3
Mean peak power (A), average power (B), time to peak power (C) during consecutive bouts of 15-s WAnTs. Data are expressed as means (square), 95% CI (box), 95% CI + SD (whisker), raw data. a–eDifferent lowercased letters refers to significant differences between the WAnT bouts (WAnT_1-WAnT_6); RM ANOVA models: †bouts x treatment, ǂbouts x treatment x treatment order and §bouts x treatment x gender).
Figure 4
Figure 4
A flow chart of the study design.
See this image and copyright information in PMC

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