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Link to original content: http://pubmed.ncbi.nlm.nih.gov/35741737/
Detoxification Role of Metabolic Glutathione S-Transferase (GST) Genes in Blood Lead Concentrations of Jamaican Children with and without Autism Spectrum Disorder - PubMed Skip to main page content
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. 2022 May 29;13(6):975.
doi: 10.3390/genes13060975.

Detoxification Role of Metabolic Glutathione S-Transferase (GST) Genes in Blood Lead Concentrations of Jamaican Children with and without Autism Spectrum Disorder

Mohammad H Rahbar  1   2   3 , Maureen Samms-Vaughan  4 , Sori Kim  2   5 , Sepideh Saroukhani  2   3 , Jan Bressler  1   6 , Manouchehr Hessabi  2 , Megan L Grove  1   6 , Sydonnie Shakspeare-Pellington  4 , Katherine A Loveland  7
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Detoxification Role of Metabolic Glutathione S-Transferase (GST) Genes in Blood Lead Concentrations of Jamaican Children with and without Autism Spectrum Disorder

Mohammad H Rahbar et al. Genes (Basel). .

Abstract

Glutathione S-transferases (GST) are involved in the detoxification of exogenous chemicals including lead (Pb). Using data from 344 pairs of autism spectrum disorder (ASD) cases and age- and sex-matched typically developing (TD) controls (2−8 years old) from Jamaica, we investigated the interaction between three GST genes and ASD status as determinants of blood Pb concentrations (BPbCs). We found that ASD cases had lower geometric mean BPbCs than TD children (1.74 vs. 2.27 µg/dL, p < 0.01). Using a co-dominant genetic model, ASD cases with the Ile/Val genotype for the GSTP1 Ile105Val polymorphism had lower GM BPbCs than TD controls, after adjusting for a known interaction between GSTP1 and GSTT1, child’s parish, socioeconomic status, consumption of lettuce, fried plantains, and canned fish (Ile/Val: 1.78 vs. 2.13 µg/dL, p = 0.03). Similarly, among carriers of the I/I or I/D (I*) genotype for GSTT1 and GSTM1, ASD cases had lower adjusted GM BPbCs than TD controls (GSTT1 I*: 1.61 vs. 1.91 µg/dL, p = 0.01; GSTM1 I*: 1.71 vs. 2.04 µg/dL, p = 0.01). Our findings suggest that genetic polymorphisms in GST genes may influence detoxification of Pb by the enzymes they encode in Jamaican children with and without ASD.

Keywords: Jamaica; autism spectrum disorder (ASD); blood lead concentrations; detoxification; glutathione S-transferase (GST) genes; heavy metals.

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Conflict of interest statement

The authors declare no conflict of interest.

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