iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: http://pubmed.ncbi.nlm.nih.gov/34569081/
Processed pseudogenes: A substrate for evolutionary innovation: Retrotransposition contributes to genome evolution by propagating pseudogene sequences with rich regulatory potential throughout the genome - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;43(11):e2100186.
doi: 10.1002/bies.202100186. Epub 2021 Sep 27.

Processed pseudogenes: A substrate for evolutionary innovation: Retrotransposition contributes to genome evolution by propagating pseudogene sequences with rich regulatory potential throughout the genome

Robin-Lee Troskie  1 , Geoffrey J Faulkner  1   2 , Seth W Cheetham  1
Affiliations

Processed pseudogenes: A substrate for evolutionary innovation: Retrotransposition contributes to genome evolution by propagating pseudogene sequences with rich regulatory potential throughout the genome

Robin-Lee Troskie et al. Bioessays. 2021 Nov.

Abstract

Processed pseudogenes may serve as a genetic reservoir for evolutionary innovation. Here, we argue that through the activity of long interspersed element-1 retrotransposons, processed pseudogenes disperse coding and noncoding sequences rich with regulatory potential throughout the human genome. While these sequences may appear to be non-functional, a lack of contemporary function does not prohibit future development of biological activity. Here, we discuss the dynamic evolution of certain processed pseudogenes into coding and noncoding genes and regulatory elements, and their implication in wide-ranging biological and pathological processes. Also see the video abstract here: https://youtu.be/iUY_mteVoPI.

Keywords: evolution; lncRNA; neofunctionalisation; pseudogene; retrotransposition.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Necsulea, A., & Kaessmann, H. (2014). Evolutionary dynamics of coding and non-coding transcriptomes. Nature Reviews Genetics, 15(11), 734-748.
    1. Long, M., Betrán, E., Thornton, K., & Wang, W. (2003). The origin of new genes: Glimpses from the young and old. Nature Reviews Genetics, 4, 865-875.
    1. Kaessmann, H. (2010). Origins, evolution, and phenotypic impact of new genes. Genome Research, 20(10), 1313-1326.
    1. Kaessmann, H., Vinckenbosch, N., & Long, M. (2009). RNA-based gene duplication: Mechanistic and evolutionary insights. Nature Reviews Genetics, 10(1), 19-31.
    1. Esnault, C., Maestre, J., & Heidmann, T. (2000). Human LINE retrotransposons generate processed pseudogenes. Nature Genetics, 24(4), 363-367.

Publication types

LinkOut - more resources