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Link to original content: http://pubmed.ncbi.nlm.nih.gov/33079128/
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. 2021 Jan-Mar;43(1):61-67.
doi: 10.1590/2175-8239-JBN-2020-0116.

The spleen size in patients undergoing hemodialysis

[Article in English, Portuguese]
Nordeval Cavalcante Araújo  1 , José Hermógenes Rocco Suassuna  1
Affiliations

The spleen size in patients undergoing hemodialysis

[Article in English, Portuguese]
Nordeval Cavalcante Araújo et al. J Bras Nefrol. 2021 Jan-Mar.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] J Bras Nefrol. 2021 Jan-Mar;43(1):142. doi: 10.1590/2175-8239-jbn-2020-0116er. J Bras Nefrol. 2021. PMID: 33503109 Free PMC article.

Abstract
in English, Portuguese

Introduction: Inflammation promotes the progression of chronic renal failure, and the start of dialysis worsens inflammation. The enlargement of the spleen is associated with inflammation, and patients on hemodialysis may show a large spleen. The aim of the present study was to compare the spleen size of patients undergoing hemodialysis versus controls to update this thread.

Methods: Controls and patients were eligible to participate in the study provided they were negative for serological markers of hepatitis B and C viruses and HIV, if they had no lymphoproliferative disorder, and if they were at least 18 years of age. Age, sex, and the duration of dialysis were recorded. Laboratory variables (hemoglobin, hematological cell count, serum creatinine) and the underlying cause of end-stage renal disease were analyzed. The spleen sizes of the patients were divided into tertiles.

Results: The 75 controls and 168 patients selected were sex-matched. The patients were older, had larger spleens and lower platelet counts than controls. The relationship between spleen size and age in the controls and patients was quite similar. The patients in the first tertile of spleen size compared with those in the third were older and had a higher platelet counts. The underlying disease and dialysis vintage had no effect on spleen size.

Discussion: The patients had larger spleens and a greater range of spleen sizes than the controls. In patients, the association between larger and smaller spleen with lower and higher platelet counts, respectively, sparked the speculation of occurrence of hypersplenism and hyposplenism.

Introdução:: A inflamação promove a progressão da insuficiência renal crônica, e o início da diálise agrava a inflamação. O aumento do baço está associado à inflamação e os pacientes em hemodiálise podem apresentar um baço grande. O objetivo do presente estudo foi comparar o tamanho do baço de pacientes em hemodiálise versus aquele de controles, para atualizar este tópico.

Métodos:: Controles e pacientes foram elegíveis para participar do estudo desde que fossem negativos para marcadores sorológicos dos vírus da hepatite B, C e HIV, se não apresentassem distúrbio linfoproliferativo e tivessem pelo menos 18 anos de idade. Registramos idade, sexo e duração da diálise. Avaliamos as variáveis laboratoriais (hemoglobina, contagem de células hematológicas, creatinina sérica) e a causa básica da doença renal terminal. O tamanho dos baços dos pacientes foram divididos em tercis.

Resultados:: Os 75 controles e 168 pacientes selecionados foram pareados por sexo. Os pacientes eram mais velhos, tinham baços maiores e menor contagem de plaquetas do que os controles. A relação entre o tamanho do baço e a idade dos controles e pacientes foi bastante semelhante. Os pacientes do primeiro tercil de tamanho do baço, em comparação com os do terceiro, eram mais velhos e apresentavam contagens de plaquetas mais altas. A doença subjacente e o período de diálise não tiveram efeito no tamanho do baço.

Discussão:: Os pacientes tinham baços maiores e uma maior variedade de tamanhos de baço do que os controles. Entre os pacientes, a associação entre baço maior e menor com contagens de plaquetas mais baixas e mais altas, respectivamente, gerou a especulação da ocorrência de hiperesplenismo e hiposplenismo.

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Conflict of interest statement

Conflict of Interest

The authors declare that they have no conflict of interest related to the publication of this manuscript.

Figures

Figure 1
Figure 1. Correlation between spleen size and age in controls and end-stage renal disease patients undergoing hemodialysis.
See this image and copyright information in PMC

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References

    1. Silverstein DM. Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular disease. Pediatr Nephrol. 2008 Aug;24(8):1445–1452. - PubMed
    1. Jofré R, Rodriguez-Benites P, López-Gómez JM, Pérez-Garcia R. Inflammatory syndrome in patients on hemodialysis. J Am Soc Nephrol. 2006 Dec;17(12) Suppl 3:S274–SS80. - PubMed
    1. Girndt M, Kaul H, Leitnaker CK, Sester M, Sester U, Köhler H. Selective sequestration of cytokine-producing monocytes during hemodialysis treatment. Am J Kidney Dis. 2001 May;37(5):954–963. - PubMed
    1. Taheri S, Baradaran A, Aliakbarian M, Mortazavi M. Level of inflammatory factors in chronic hemodialysis patients with and without cardiovascular disease. J Res Med Sci. 2017 Apr;22:47–47. - PMC - PubMed
    1. Li Y, Wu J, Xu L, Wu Q, Wan Z, Li L. Regulation of leukocyte recruitment to the spleen and peritoneal cavity during pristane-induced inflammation. J Immunol Res. 2017;2017:9891348–9891348. - PMC - PubMed