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Link to original content: http://pubmed.ncbi.nlm.nih.gov/31845589/
Auditory event-related potentials and associations with sensory patterns in children with autism spectrum disorder, developmental delay, and typical development - PubMed Skip to main page content
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Observational Study
. 2020 Jul;24(5):1093-1110.
doi: 10.1177/1362361319893196. Epub 2019 Dec 17.

Auditory event-related potentials and associations with sensory patterns in children with autism spectrum disorder, developmental delay, and typical development

Franc Cl Donkers  1   2 , Mike Carlson  3 , Sarah E Schipul  1 , Aysenil Belger  1   4 , Grace T Baranek  1   3
Affiliations
Observational Study

Auditory event-related potentials and associations with sensory patterns in children with autism spectrum disorder, developmental delay, and typical development

Franc Cl Donkers et al. Autism. 2020 Jul.

Abstract

Atypical sensory response patterns are common in children with autism and developmental delay. Expanding on previous work, this observational electroencephalogram study assessed auditory event-related potentials and their associations with clinically evaluated sensory response patterns in children with autism spectrum disorder (n = 28), developmental delay (n = 17), and typical development (n = 39). Attention-orienting P3a responses were attenuated in autism spectrum disorder relative to both developmental delay and typical development, but early sensory N2 responses were attenuated in both autism spectrum disorder and developmental delay relative to typical development. Attenuated event-related potentials involving N2 or P3a components, or a P1 × N2 interaction, were related to more severe hyporesponsive or sensory-seeking response patterns across children with autism spectrum disorder and developmental delay. Thus, although attentional disruptions may be unique to autism spectrum disorder, sensory disruptions appear across developmental delay and are associated with atypical sensory behaviors.

Keywords: autism spectrum disorders; development; sensory impairments.

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Conflict of interest statement

Declaration of Conflicting Interest

The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Grand averaged ERPs to standard stimuli. Time is in seconds. Time = 0 indicates stimulus onset. TD = typically developing group. ASD = group with autism. DD = developmentally disabled group
Figure 2.
Figure 2.
Grand averaged ERPs to duration-deviant stimuli. Time is in seconds. Time = 0 indicates stimulus onset. TD = typically developing group. ASD = group with autism. DD = developmentally disabled group
Figure 3.
Figure 3.
Grand averaged ERPs to pitch-deviant stimuli. Time is in seconds. Time = 0 indicates stimulus onset. TD = typically developing group. ASD = group with autism. DD = developmentally disabled group
Figure 4.
Figure 4.
Grand averaged ERPs to novel stimuli. Time is in seconds. Time = 0 indicates stimulus onset. TD = typically developing group. ASD = group with autism. DD = developmentally disabled group
See this image and copyright information in PMC

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