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. 2019 Apr 15;20(8):1847.
doi: 10.3390/ijms20081847.

The Association Between Affective Temperament Traits and Dopamine Genes in Obese Population

Natalia Lesiewska  1 , Alina Borkowska  2 , Roman Junik  3 , Anna Kamińska  4 , Joanna Pulkowska-Ulfig  5 , Andrzej Tretyn  6 , Maciej Bieliński  7
Affiliations

The Association Between Affective Temperament Traits and Dopamine Genes in Obese Population

Natalia Lesiewska et al. Int J Mol Sci. .

Abstract

Studies indicate the heritable nature of affective temperament, which shows personality traits predisposing to the development of mental disorders. Dopaminergic gene polymorphisms such as DRD4, COMTVal158Met, and DAT1 have been linked to affective disorders in obesity. Due to possible correlation between the aforementioned polymorphisms and the affective temperament, the aim of our research was to investigate this connection in an obese population. The study enrolled 245 obese patients (178 females; 67 males). The affective temperament was assessed using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS-A). Genetic polymorphisms of DAT1, COMTVal158Met and DRD4 were collected from peripheral blood sample and determined using a polymerase chain reaction (PCR). Only in COMT polymorphisms, the cyclothymic and irritable dimensions were significantly associated with Met/Val carriers (p = 0.04; p = 0.01). Another interesting finding was the correlation between the affective temperament and age in men and women. We assume that dopamine transmission in heterozygotes of COMT may determine the role of the affective temperament in obese persons. Dopaminergic transmission modulated by COMT may be responsible for a greater temperament expression in obese individuals. To our knowledge, this is the first study describing the role of affective temperament in the obese population, but more research is needed in this regard.

Keywords: affective temperament; dopaminergic gene polymorphisms; obesity.

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Conflict of interest statement

All authors declare no conflict of interests connected with this manuscript.

Figures

Figure 1
Figure 1
Photo of the digested COMT PCR products. The results are labeled by genotype: Met/Met (A/A), 96 bp only; Val/Met (A/G) 114 and 96 bp; and Val/Val (G/G), 114 bp only.
Figure 2
Figure 2
Photo of digested DAT1 PCR products. The results are labeled by genotype: 10/10 (L/L) 483 bp only; 10/9 (L/S) 483 and 443 bp; and 9/9 (S/S) 443 bp only.
Figure 3
Figure 3
Photo of digested DRD4 PCR products. Representative photo of separated DRD4 PCR products depending on the genotype: LL—only 619 bp band (7R); S/S 379 bd (2R) or/and 427 bp (3R) or/and 523 bp (5R) band; L/S – 379 bd (2R) or 427 bp (3R) or 523 bp (5R) and 619 bp (7R) bands.
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