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Link to original content: http://pubmed.ncbi.nlm.nih.gov/30337548/
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. 2018 Oct 18;8(1):15428.
doi: 10.1038/s41598-018-33586-6.

The role of functional and structural interhemispheric auditory connectivity for language lateralization - A combined EEG and DTI study

Saskia Steinmann  1 , Rom Amselberg  2 , Bastian Cheng  3 , Götz Thomalla  3 , Andreas K Engel  4 , Gregor Leicht  2 , Christoph Mulert  2   5
Affiliations

The role of functional and structural interhemispheric auditory connectivity for language lateralization - A combined EEG and DTI study

Saskia Steinmann et al. Sci Rep. .

Erratum in

Abstract

Interhemispheric connectivity between auditory areas is highly relevant for normal auditory perception and alterations are a major factor for the development of auditory verbal hallucinations. Surprisingly, there is no combined EEG-DTI study directly addressing the role of functional and structural connectivity in the same group of subjects. Accordingly, nothing is known about the relationship between functional connectivity such as gamma-band synchrony, structural integrity of the interhemispheric auditory pathways (IAPs) and language lateralization as well as whether the gamma-band synchrony is configured on the backbone of IAPs. By applying multimodal imaging of 64-channel EEG and DTI tractography, we investigated in 27 healthy volunteers the functional gamma-band synchrony between either bilateral primary or secondary auditory cortices from eLORETA source-estimation during dichotic listening, as well as the correspondent IAPs from which fractional anisotropy (FA) values were extracted. Correlation and regression analyses revealed highest values for gamma-band synchrony, followed by FA for secondary auditory cortices, which were both significantly related to a reduced language lateralization. There was no such association between the white-matter microstructure and gamma-band synchrony, suggesting that structural connectivity might also be relevant for other (minor) aspects of information transfer in addition to gamma-band synchrony, which are not detected in the present coupling analyses. The combination of multimodal EEG-DTI imaging provides converging evidence of neural correlates by showing that both stronger pathways and increased gamma-band synchrony within one cohort of subjects are related to a reduced leftward-lateralization for language.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Dichotic listening paradigm. After a fixation cross presented on a blank screen for 1000 ms, the syllables were presented bilaterally. Next, the screen showed all six syllables presented in a circular formation. By clicking with the right (dominant) hand the left mouse button it was possible to navigate through the six answer alternatives and with the right mouse button the selection was confirmed. Between the offset of the visual presentation and the onset of the next auditory stimulus a stable interstimulus interval of 1000 ms was applied.
Figure 2
Figure 2
White background (red): EEG-ROIs created in LORETA in standard space. Black background: DTI-ROIs created in FSL in standard space (blue). (A) Heschl’s gyrus (B) posterior superior temporal gyrus (pSTG) (C) 3D illustration of Heschl’s gyri (red), pSTG (blue) and midsagittal callosal body (yellow).
Figure 3
Figure 3
Group mean tractographies. Cumulated fiber densities per voxel connecting (A) Heschl’s gyrus (HG) and (B) posterior superior temporal gyrus (pSTG) on both hemispheres in standard space (MNI152). Note that the intensity (red-yellow gradient) represents how many tracks pass through each voxel. P: posterior; A: anterior; R: right; L: left.
Figure 4
Figure 4
Scatterplots showing the significant association between (A) the mean fractional anisotropy (FA) value of the interhemispheric auditory pathway connecting homolog posterior superior temporal gyrus (pSTG), or (B) the mean gamma-band synchrony (lagged phase synchronization/LPS) connecting either pSTG or Heschl’s gyrus (HG), and the dichotic listening (DL) performance (all p < 0.05). (C) Scatterplots showing the non-significant relation between gamma-band synchrony and the mean FA values of the interhemispheric auditory pathway connecting either homolog pSTG or HG.
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