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Link to original content: http://pubmed.ncbi.nlm.nih.gov/29398807/
Value of Soluble Transferrin Receptors and sTfR/log Ferritin in the Diagnosis of Iron Deficiency Accompanied by Acute Infection - PubMed Skip to main page content
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. 2018 Jan;34(1):104-109.
doi: 10.1007/s12288-017-0836-6. Epub 2017 May 25.

Value of Soluble Transferrin Receptors and sTfR/log Ferritin in the Diagnosis of Iron Deficiency Accompanied by Acute Infection

Fady M El-Gendy  1 , Mahmoud A El-Hawy  1 , Mohamed S Rizk  2 , Sally M El-Hefnawy  2 , Mohamed Z Mahmoud  1
Affiliations

Value of Soluble Transferrin Receptors and sTfR/log Ferritin in the Diagnosis of Iron Deficiency Accompanied by Acute Infection

Fady M El-Gendy et al. Indian J Hematol Blood Transfus. 2018 Jan.

Abstract

There are many causes of anemia; the most common of these are acute and chronic infections, iron deficiency, or both. Identifying the cause is a very important step in management of anemia. So, we evaluated the usefulness of soluble transferrin receptor (sTfR) and of the sTfR/log ferritin in the diagnosis of iron deficiency anemia accompanied by acute infection. This study was conducted on 131 children aged 2-11 years old from those who attended the pediatric outpatient clinics in Menoufia university hospital. Hematological indices, iron balance and sTfR were evaluated and the sTfR/log F was calculated for each examined child. From the examined children four groups were distinguished: Group I (control): included 34 healthy children with normal iron status (66.7% males, age 4.2 ± 1.2). Group II (IDA): included 38 children diagnosed as iron deficiency anemia (47.4% males, age 4.9 ± 1.6). Group III (IDA + infection): included 26 children with infectious disease (upper respiratory tract infection, otitis media, pneumonia, stomatitis, and urinary tract infection) and anemia meeting criteria of IDA (50% males, age 4.2 ± 0.7). Group IV (anemia + infection): included 33 children with infectious anemia without iron deficiency (56.2% males, age 5.06 ± 1.4). It was proved that sTfR and sTfR/log Ferritin were significantly higher in children with anemia due to iron deficiency, and in those with infection + iron deficiency, versus those with infectious anemia or in healthy children. The use of sTfR and sTfR/log ferritin improves the diagnosis of IDA in pediatric patients, especially in the presence of coexisting acute infection.

Keywords: Anemia; Infection; sTfR; sTfR/log ferritin.

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Figures

Fig. 1
Fig. 1
ROC curve (receiver operating curve) for prediction of iron deficiency anemia using STFR (mg/l) and sTfR-F index shows AUC (area under the curve) 0.913 and 0.986 respectively. sTfR soluble transferrin receptor, sTfR-F index soluble transferrin receptor-ferritin index
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