iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: http://pubmed.ncbi.nlm.nih.gov/26810546/
Epstein-Barr virus and multiple sclerosis. From evidence to therapeutic strategies - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Feb 15:361:213-9.
doi: 10.1016/j.jns.2016.01.013. Epub 2016 Jan 6.

Epstein-Barr virus and multiple sclerosis. From evidence to therapeutic strategies

Santiago Fernández-Menéndez  1 , Marta Fernández-Morán  2 , Iván Fernández-Vega  3 , Angel Pérez-Álvarez  4 , Javier Villafani-Echazú  4
Affiliations
Review

Epstein-Barr virus and multiple sclerosis. From evidence to therapeutic strategies

Santiago Fernández-Menéndez et al. J Neurol Sci. .

Abstract

Multiple sclerosis is caused by a complex interaction between genetic predisposition and environmental factors. Epstein-Barr virus (EBV) is an environmental risk factor that is strongly related to multiple sclerosis (MS), since EBV seropositivity is linked to a significant risk of developing MS. EBV may be involved in the pathogenesis of the disease and it is possibly a prerequisite for the development of MS. EBV infection persists in B-cells during the lifetime of the host and can modulate their function. In addition, MS patients might have a deficient capacity to eliminate latent EBV infection in the central nervous system and this would promote the accumulation of infected B cells. Several mechanisms of pathogenesis, including a direct and indirect function of infected B cells, have been postulated in inflammation and neurodegeneration. A relationship between EBV and human endogenous retroviruses in the pathogenesis of MS has also been reported. If EBV is important in the pathogenesis of MS, different therapeutic strategies seem possible for MS treatment.

Keywords: B-cell; CD20; Epstein–Barr virus; Human endogenous retroviruses; Multiple sclerosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources