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Review
. 2015 Sep;11(3):342-54.
doi: 10.1007/s13181-015-0488-6.

A Review of the Toxicologic Implications of Obesity

Matthew Zuckerman  1 , Howard A Greller, Kavita M Babu
Affiliations
Review

A Review of the Toxicologic Implications of Obesity

Matthew Zuckerman et al. J Med Toxicol. 2015 Sep.

Abstract

The increasing prevalence of obesity in developed nations has far-reaching implications for medical toxicology. The management of obese patients is complicated by comorbid illnesses, changes in cardiovascular and respiratory physiology, alterations in pharmacokinetics, and a lack of studies to identify appropriate dosing for current therapeutics and antidotes. In this review article, we examine obesity-associated physiologic and pharmacokinetic changes that may increase the vulnerability of obese patients to overdose. Further research is needed to characterize the relationship between drug toxicity and obesity.

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Figures

Fig. 1
Fig. 1
Prevalence of obesity and normal weight adults as percent of US population. Data from [6, 7]
Fig. 2
Fig. 2
Body composition as a function of BMI. Estimated mass (kg) of various body compartments in an average 1.78-m male. Fat body weight is the difference between TBW and LBW calculated by Jamahasatians formulae. Blood weight is calculated [19]. LBW* LBW calculated by Janmahasatians formulae minus blood weight to give a blood-free LBW
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