iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: http://pubmed.ncbi.nlm.nih.gov/25999228/
Human granulocytic anaplasmosis - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun;29(2):341-55.
doi: 10.1016/j.idc.2015.02.007.

Human granulocytic anaplasmosis

Johan S Bakken  1 , J Stephen Dumler  2
Affiliations
Review

Human granulocytic anaplasmosis

Johan S Bakken et al. Infect Dis Clin North Am. 2015 Jun.

Abstract

Human granulocytic anaplasmosis, a deer tick-transmitted rickettsial infection caused by Anaplasma phagocytophilum, is a common cause of undifferentiated fever in the northeast and upper Midwest United States. Patients are often initially diagnosed with a mild viral infection, and illness readily resolves in most cases. However, as many as 3% develop life-threatening complications and nearly 1% die from the infection. Although coinfections with Borrelia burgdorferi and Babesia microti occur, there is little evidence to suggest synergism of disease or a role for A phagocytophilum in chronic illness. No vaccine is available.

Keywords: Anaplasmosis; Diagnosis; Granulocytic; Human; Management.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Reported cases of tick-borne rickettsial infections in the U.S., 1987-2013. The cumulative area plots demonstrate the overall burden of infection during this time interval. HGA – human granulocytic anaplasmosis; HME – human monocytic ehrlichiosis; spotted fever – spotted fever group rickettsioses, including Rocky Mountain spotted fever; nos – not otherwise specified. Data extracted from Morbidity and Mortality Weekly Reports, 1987-2014.
Figure 2
Figure 2
Anaplasma phagocytophilum-infected band neutrophil in human peripheral blood (Wright stain, original magnification × 260). The top left inset shows the same band neutrophil and demonstrates several morulae with a stippled basophilic appearance corresponding to individual bacteria (magnification × 520). The bottom right insert shows A. phagocytophilum cultivated in vitro in the human promyelocytic leukemia cell line HL-60. Here, the individual basophilic bacteria are easily visualized within vacuoles of the infected cell (LeukoStat stain; magnification × 520).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ricketts HT. The study of “Rocky Mountain spotted fever“ (tick fever) by means of animal inoculations. J Am Med Assoc. 1906;47:1–10.
    1. Pritt BS, McFadden JD, Stromdahl E, et al. Emergence of a novel Ehrlichia sp. agent pathogenic for humans in the Midwestern United States. 6th International Meeting on Rickettsiae and Rickettsial Diseases; Heraklion, Crete, Greece: Hellenic Society for Infectious Diseases; 2011. Abstract no P075.
    1. Platonov AE, Karan LS, Kolyasnikova NM, et al. Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia. Emerg Infect Dis. 2011;17:1816–23. - PMC - PubMed
    1. Steere AC, Malawista SE, Snydman DR, et al. Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. Arthritis and rheumatism. 1977;20:7–17. - PubMed
    1. Maeda K, Markowitz N, Hawley RC, Ristic M, Cox D, McDade JE. Human infection with Ehrlichia canis, a leukocytic rickettsia. N Engl J Med. 1987;316:853–6. - PubMed

Publication types

MeSH terms