Alcohol consumption and risk of dementia up to 27 years later in a large, population-based sample: the HUNT study, Norway

doi:10.1007/s10654-015-0029-2

. 2015 Sep;30(9):1049-56.

doi: 10.1007/s10654-015-0029-2. Epub 2015 May 13.

Alcohol consumption and risk of dementia up to 27 years later in a large, population-based sample: the HUNT study, Norway

Ellen Melbye Langballe^{1

2}, Helga Ask³, Jostein Holmen⁴, Eystein Stordal^{5

6}, Ingvild Saltvedt^{6

7}, Geir Selbæk^{8

9

10}, Arvid Fikseaunet¹¹, Sverre Bergh⁹, Per Nafstad^{12

13}, Kristian Tambs³

Affiliations

¹ Division of Mental Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Nydalen, Oslo, Norway. eml@aldringoghelse.no.
² Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway. eml@aldringoghelse.no.
³ Division of Mental Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Nydalen, Oslo, Norway.
⁴ HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology (NTNU), Levanger, Norway.
⁵ Namsos Hospital, Nord-Trøndelag Health Trust, Namsos, Norway.
⁶ Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
⁷ Department of Geriatrics, St Olav Hospital, University Hospital of Trondheim, Trondheim, Norway.
⁸ Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
⁹ Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, P.O. Box 68, 2312, Ottestad, Norway.
¹⁰ Akershus University Hospital, Lørenskog, Norway.
¹¹ Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway.
¹² Institute of Health and Society, University of Oslo, Pb 1130 Blindern, 0318, Oslo, Norway.
¹³ Division of Epidemiology, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Nydalen, Oslo, Norway.

PMID: 25968174
PMCID: PMC4584101
DOI: 10.1007/s10654-015-0029-2

Alcohol consumption and risk of dementia up to 27 years later in a large, population-based sample: the HUNT study, Norway

Ellen Melbye Langballe et al. Eur J Epidemiol. 2015 Sep.

. 2015 Sep;30(9):1049-56.

doi: 10.1007/s10654-015-0029-2. Epub 2015 May 13.

Authors

Affiliations

¹ Division of Mental Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Nydalen, Oslo, Norway. eml@aldringoghelse.no.
² Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway. eml@aldringoghelse.no.
³ Division of Mental Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Nydalen, Oslo, Norway.
⁴ HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology (NTNU), Levanger, Norway.
⁵ Namsos Hospital, Nord-Trøndelag Health Trust, Namsos, Norway.
⁶ Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
⁷ Department of Geriatrics, St Olav Hospital, University Hospital of Trondheim, Trondheim, Norway.
⁸ Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
⁹ Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, P.O. Box 68, 2312, Ottestad, Norway.
¹⁰ Akershus University Hospital, Lørenskog, Norway.
¹¹ Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway.
¹² Institute of Health and Society, University of Oslo, Pb 1130 Blindern, 0318, Oslo, Norway.
¹³ Division of Epidemiology, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Nydalen, Oslo, Norway.

PMID: 25968174
PMCID: PMC4584101
DOI: 10.1007/s10654-015-0029-2

Abstract

The relationship between alcohol consumption and dementia risk is unclear. This investigation estimates the association between alcohol consumption reported in a population-based study in the mid-1980s and the risk for dementia up to 27 years later. The entire adult population in one Norwegian county was invited to the Nord-Trøndelag Health Study during 1984-1986 (HUNT1): 88 % participated. The sample used in this study includes HUNT1 participants born between 1905 and 1946 who completed the questionnaire assessing alcohol consumption. A total of 40,435 individuals, of whom 1084 have developed dementia, are included in the analysis adjusted for age, sex, years of education, hypertension, obesity, smoking, and symptoms of depression. When adjusting for age and sex, and compared to reporting consumption of alcohol 1-4 times during the last 14 days (drinking infrequently), both abstaining from alcohol and reporting consumption of alcohol five or more times (drinking frequently) were statistically significantly associated with increased dementia risk with hazard ratios of 1.30 (95 % CI 1.05-1.61) and 1.45 (1.11-1.90), respectively. In the fully adjusted analysis, drinking alcohol frequently was still significantly associated with increased dementia risk with a hazard ratio of 1.40 (1.07-1.84). However, the association between dementia and abstaining from alcohol was no longer significant (1.15, 0.92-1.43). Equivalent results for Alzheimer's disease and vascular dementia indicated the same patterns of associations. When adjusting for other factors associated with dementia, frequent alcohol drinking, but not abstaining from alcohol, is associated with increased dementia risk compared to drinking alcohol infrequently.

Keywords: Alcohol consumption; Dementia; Epidemiology; Longitudinal study; Risk factor.

PubMed Disclaimer

Cited by

Transgenic expression of human cytochrome P450 2E1 in C. elegans and rat PC-12 cells sensitizes to ethanol-induced locomotor and mitochondrial effects.
Gonzalez HC, Misare KR, Mendenhall TT, Wolf BJ, Mulholland PJ, Gordon KL, Hartman JH. Gonzalez HC, et al. Biochem Biophys Res Commun. 2024 Nov 19;734:150735. doi: 10.1016/j.bbrc.2024.150735. Epub 2024 Sep 24. Biochem Biophys Res Commun. 2024. PMID: 39357336
Association between alcohol consumption and incidence of dementia in current drinkers: linear and non-linear mendelian randomization analysis.
Zheng L, Liao W, Luo S, Li B, Liu D, Yun Q, Zhao Z, Zhao J, Rong J, Gong Z, Sha F, Tang J. Zheng L, et al. EClinicalMedicine. 2024 Sep 5;76:102810. doi: 10.1016/j.eclinm.2024.102810. eCollection 2024 Oct. EClinicalMedicine. 2024. PMID: 39290634 Free PMC article.
Early-Stage Moderate Alcohol Feeding Dysregulates Insulin-Related Metabolic Hormone Expression in the Brain: Potential Links to Neurodegeneration Including Alzheimer's Disease.
Yang Y, Tong M, de la Monte SM. Yang Y, et al. J Alzheimers Dis Rep. 2024 Sep 5;8(1):1211-1228. doi: 10.3233/ADR-240026. eCollection 2024. J Alzheimers Dis Rep. 2024. PMID: 39247872 Free PMC article.
Charting Alzheimer's Disease and Dementia: Epidemiological Insights, Risk Factors and Prevention Pathways.
Contador I, Buch-Vicente B, Del Ser T, Llamas-Velasco S, Villarejo-Galende A, Benito-León J, Bermejo-Pareja F. Contador I, et al. J Clin Med. 2024 Jul 13;13(14):4100. doi: 10.3390/jcm13144100. J Clin Med. 2024. PMID: 39064140 Free PMC article. Review.
A multi-ethnic proteomic profiling analysis in Alzheimer's disease identifies the disparities in dysregulation of proteins and pathogenesis.
Tan MS, Cheah PL, Chin AV, Looi LM, Chang SW. Tan MS, et al. PeerJ. 2024 Jul 18;12:e17643. doi: 10.7717/peerj.17643. eCollection 2024. PeerJ. 2024. PMID: 39035156 Free PMC article.

See all "Cited by" articles

References

1. Kopelman MD, Thomson AD, Guerrini I, Marshall EJ. The Korsakoff syndrome: clinical aspects, psychology and treatment. Alcohol Alcohol. 2009;44:148–154. doi: 10.1093/alcalc/agn118. - DOI - PubMed
1. Järvenpää T, Rinne JO, Koskenvuo M, Räihä I, Kaprio J. Binge drinking in midlife and dementia risk. Epidemiology. 2005;16:766–771. doi: 10.1097/01.ede.0000181307.30826.6c. - DOI - PubMed
1. Kim JW, Lee DY, Lee BC, et al. Alcohol and cognition in the elderly: a review. Psychiatry Investig. 2012;9:8–16. doi: 10.4306/pi.2012.9.1.8. - DOI - PMC - PubMed
1. Harwood DG, Kalechstein A, Barker WW, et al. The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer’s disease. Int J Geriatr Psychiatry. 2010;25(5):511–518. doi: 10.1002/gps.2372. - DOI - PubMed
1. Ruitenberg A, van Swieten JC, Witteman J, et al. Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet. 2002;359:281–286. doi: 10.1016/S0140-6736(02)07493-7. - DOI - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Kopelman MD, Thomson AD, Guerrini I, Marshall EJ. The Korsakoff syndrome: clinical aspects, psychology and treatment. Alcohol Alcohol. 2009;44:148–154. doi: 10.1093/alcalc/agn118. - DOI - PubMed

[2] Kopelman MD, Thomson AD, Guerrini I, Marshall EJ. The Korsakoff syndrome: clinical aspects, psychology and treatment. Alcohol Alcohol. 2009;44:148–154. doi: 10.1093/alcalc/agn118. - DOI - PubMed

[3] Järvenpää T, Rinne JO, Koskenvuo M, Räihä I, Kaprio J. Binge drinking in midlife and dementia risk. Epidemiology. 2005;16:766–771. doi: 10.1097/01.ede.0000181307.30826.6c. - DOI - PubMed

[4] Järvenpää T, Rinne JO, Koskenvuo M, Räihä I, Kaprio J. Binge drinking in midlife and dementia risk. Epidemiology. 2005;16:766–771. doi: 10.1097/01.ede.0000181307.30826.6c. - DOI - PubMed

[5] Kim JW, Lee DY, Lee BC, et al. Alcohol and cognition in the elderly: a review. Psychiatry Investig. 2012;9:8–16. doi: 10.4306/pi.2012.9.1.8. - DOI - PMC - PubMed

[6] Kim JW, Lee DY, Lee BC, et al. Alcohol and cognition in the elderly: a review. Psychiatry Investig. 2012;9:8–16. doi: 10.4306/pi.2012.9.1.8. - DOI - PMC - PubMed

[7] Harwood DG, Kalechstein A, Barker WW, et al. The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer’s disease. Int J Geriatr Psychiatry. 2010;25(5):511–518. doi: 10.1002/gps.2372. - DOI - PubMed

[8] Harwood DG, Kalechstein A, Barker WW, et al. The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer’s disease. Int J Geriatr Psychiatry. 2010;25(5):511–518. doi: 10.1002/gps.2372. - DOI - PubMed

[9] Ruitenberg A, van Swieten JC, Witteman J, et al. Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet. 2002;359:281–286. doi: 10.1016/S0140-6736(02)07493-7. - DOI - PubMed

[10] Ruitenberg A, van Swieten JC, Witteman J, et al. Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet. 2002;359:281–286. doi: 10.1016/S0140-6736(02)07493-7. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Alcohol consumption and risk of dementia up to 27 years later in a large, population-based sample: the HUNT study, Norway

Affiliations

Alcohol consumption and risk of dementia up to 27 years later in a large, population-based sample: the HUNT study, Norway

Authors

Affiliations

Abstract

Similar articles

Cited by

References

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Similar articles

Cited by

References

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical