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Link to original content: http://pubmed.ncbi.nlm.nih.gov/24399558/
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Comment
. 2014 Jan 8;311(2):193-4.
doi: 10.1001/jama.2013.283787.

Pharmacological treatments for smoking cessation

Kate Cahill  1 , Sarah Stevens  2 , Tim Lancaster  1
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Pharmacological treatments for smoking cessation

Kate Cahill et al. JAMA. .

Abstract

Clinical question: Among the 3 first-line smoking cessation treatments (nicotine replacement therapy [NRT], bupropion, and varenicline), which is most effective in helping people who smoke achieve and maintain abstinence from smoking for at least 6 months, and what serious adverse events are associated with each?

Bottom line: Higher rates of smoking cessation were associated with NRT (17.6%) and bupropion (19.1%) compared with placebo (10.6%). Varenicline (27.6%) and combination NRT (31.5%) (eg, patch plus inhaler) were most effective for achieving smoking cessation. None of the therapies was associated with an increased rate of serious adverse events.

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