Comparative Study
doi: 10.1093/jnci/82.15.1272.
Evidence for mendelian inheritance in the pathogenesis of lung cancer
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- PMID: 2374177
- DOI: 10.1093/jnci/82.15.1272
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Comparative Study
Evidence for mendelian inheritance in the pathogenesis of lung cancer
J Natl Cancer Inst.
.
Abstract
Segregation analyses that allowed for variable age of onset of lung cancer and smoking history were performed on 337 families, each ascertained through a lung cancer proband. Results indicated compatibility of the data with mendelian codominant inheritance of a rare major autosomal gene that produces earlier age of onset of the cancer. Segregation at this putative locus could account for 69% and 47% of the cumulative incidence of lung cancer in individuals up to ages 50 and 60, respectively. The gene was involved in only 22% of all lung cancers in persons up to age 70, a reflection of an increasing proportion of noncarriers succumbing to the effects of long-term exposure to tobacco.
Comment in
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Heredity as a determining factor in which smokers die of lung cancer.J Natl Cancer Inst. 1991 Jan 2;83(1):64-6. doi: 10.1093/jnci/83.1.64. J Natl Cancer Inst. 1991. PMID: 1984522 No abstract available.
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Interactions of genes, environment, and life-style in lung cancer development.J Natl Cancer Inst. 1990 Aug 1;82(15):1236-7. doi: 10.1093/jnci/82.15.1236. J Natl Cancer Inst. 1990. PMID: 2374172 No abstract available.
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