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Link to original content: http://pubmed.ncbi.nlm.nih.gov/21067973/
Microbial and viral pathogens in colorectal cancer - PubMed Skip to main page content
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Review
. 2011 May;12(5):504-12.
doi: 10.1016/S1470-2045(10)70186-8. Epub 2010 Nov 8.

Microbial and viral pathogens in colorectal cancer

Danielle Collins  1 , Aisling M Hogan, Desmond C Winter
Affiliations
Review

Microbial and viral pathogens in colorectal cancer

Danielle Collins et al. Lancet Oncol. 2011 May.

Abstract

The heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial-epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.

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