iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: http://pubmed.ncbi.nlm.nih.gov/20696045/
Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Aug 9:6:7.
doi: 10.1186/1745-9974-6-7.

Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome

Yoshihisa Ishiura  1 , Masaki Fujimura, Hiroki Yamamoto, Noriyuki Ohkura, Shigeharu Myou
Affiliations

Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome

Yoshihisa Ishiura et al. Cough. .

Abstract

Background: Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase (COX)-2, one of the inducible isoforms of COX, is a key element in the pathophysiological process of a number of inflammatory disorders. However, little is known about the role of COX-2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation.

Methods: The effect of etodolac, a potent COX-2 inhibitor, on cough response to inhaled capsaicin was examined in 15 patients with sinobronchial syndrome in a randomized, placebo-controlled cross-over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity.

Results: The cough threshold was significantly (p < 0.03) increased after two-week treatment with etodolac (200 mg twice a day orally) compared with placebo [37.5 (GSEM 1.3) vs. 27.2 (GSEM 1.3) muM].

Conclusions: These findings indicate that COX-2 may be a possible modulator augmenting airway cough reflex sensitivity in patients with sinobronchial syndrome.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Individual data of capsaicin cough threshold before each treatment and after placebo and etodolac treatments in patients with chronic bronchitis. Each horizontal bar represents geometric mean value. * P < 0.03: an one-way analysis of variance using logarithmically transformed values.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Homma H, Yamanaka A, Tanimoto S, Tamura M, Chijimatsu Y, Kira S, Izumi T. Diffuse panbronchiolitis; a disease of the transitional zone of the lung. Chest. 1983;83:63–69. doi: 10.1378/chest.83.1.63. - DOI - PubMed
    1. Kudoh S, Azuma A, Yamamoto M, Izumi T, Ando M. Improvement of survival in patients with diffuse panbronchiolitis treated with low-dose erythromycin. Am J Respir Crit Care Med. 1998;157:1829–1832. - PubMed
    1. Ishiura Y, Fujimura M, Saito M, Shibata K, Nomura M, Nakatsumi Y, Matsuda T. Additive effect of continuous low-dose ofloxacin on erythromycin therapy for sinobronchial syndrome. Respir Med. 1995;89:677–684. doi: 10.1016/0954-6111(95)90135-3. - DOI - PubMed
    1. Kurashima K, Fujimura M, Hoyano Y, Takemura K, Matsuda T. Effect of thromboxane A2 synthetase inhibitor, OKY-046, on sputum in chronic bronchitis and diffuse panbronchiolitis. Eur Respir J. 1995;8:1705–1711. doi: 10.1183/09031936.95.08101705. - DOI - PubMed
    1. Tamaoki J, Chiyotani A, Kobayashi K, Sakai N, Kanemura T, Takizawa T. Effect of indomethacin on bronchorrhea in patients with chronic bronchitis, diffuse panbronchiolitis, or bronchiectasis. Am Rev Respir Dis. 1992;145:548–552. - PubMed