Review
doi: 10.2217/fmb.10.61.
Human herpesvirus-6 entry into host cells
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- PMID: 20632802
- DOI: 10.2217/fmb.10.61
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Review
Human herpesvirus-6 entry into host cells
Future Microbiol.
2010 Jul.
Abstract
Human herpesvirus-6 (HHV-6) belongs to the herpesvirus family and is categorized into variant A and B (HHV-6A and HHV-6B). Primary HHV-6 infection in children and its related diseases are almost exclusively caused by HHV-6B and no disease caused by HHV-6A has been identified. The cellular receptor of HHV-6 has been shown to be a human CD46, and its viral ligand is an envelope glycoprotein complex, gH/gL/gQ1/gQ2 in HHV-6A. Furthermore, both cellular and viral lipid rafts play an important role in the HHV-6 entry process, suggesting that HHV-6 may enter its target cells through a lipid raft-associated mechanism.
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