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Link to original content: http://pubmed.ncbi.nlm.nih.gov/19847206/
Integrase-defective lentiviral vectors: progress and applications - PubMed Skip to main page content
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Review
. 2010 Feb;17(2):150-7.
doi: 10.1038/gt.2009.135. Epub 2009 Oct 22.

Integrase-defective lentiviral vectors: progress and applications

M B Banasik  1 , P B McCray Jr
Affiliations
Review

Integrase-defective lentiviral vectors: progress and applications

M B Banasik et al. Gene Ther. 2010 Feb.

Abstract

Lentiviral vectors (LVs) offer the advantages of a large packaging capacity, broad cell tropism or specific cell-type targeting through pseudotyping, and long-term expression from integrated gene cassettes. However, transgene integration carries a risk of disrupting gene expression through insertional mutagenesis and may not be required for all applications. A non-integrating LV may be beneficial in cases in which transient gene expression is desired. Several recent publications outline the development and initial biological characterization of such vectors. Here, we discuss the potential applications and new directions for the development of integration-defective LVs.

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