Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats
- PMID: 17097082
- DOI: 10.1016/j.ejphar.2006.09.064
Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats
Abstract
Using conflict drinking and forced swimming tests in rats, we examined the anxiolytic- and the antidepressant-like activity, respectively, of (2R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]-pyrrolidine (SB 269970), a selective 5-HT(7) receptor antagonist, after its intrahippocampal administration. SB 269970 at doses of 0.3, 1 and 3 mug showed an anticonflict effect which was weaker than that of diazepam (40 mug), whereas SB 269970 at doses of 3 and 10 mug had marked anti-immobility action comparable to that of imipramine (0.1 mug). Importantly, the anxiolytic- and antidepressant-like activity of SB 269970 seemed to be specific, since that agent - when given by the same route in doses effective in either model - affected neither the shock threshold, nor the non-punished water consumption, nor the exploratory activity of rats. The obtained results indicate that the hippocampus is one of the neuroanatomical structures involved in the potential anxiolytic and, in particular, antidepressant activity of SB 269970.
Similar articles
-
Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats.Behav Pharmacol. 2007 Sep;18(5-6):439-46. doi: 10.1097/FBP.0b013e3282d28f9c. Behav Pharmacol. 2007. PMID: 17762512
-
Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression.Neuropharmacology. 2007 Apr;52(5):1274-83. doi: 10.1016/j.neuropharm.2007.01.007. Epub 2007 Jan 20. Neuropharmacology. 2007. PMID: 17320917
-
Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression.Neuropharmacology. 2006 Sep;51(3):578-86. doi: 10.1016/j.neuropharm.2006.04.017. Epub 2006 Jul 7. Neuropharmacology. 2006. PMID: 16828124
-
Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents.J Pharmacol Exp Ther. 2007 May;321(2):690-8. doi: 10.1124/jpet.107.119404. Epub 2007 Feb 21. J Pharmacol Exp Ther. 2007. PMID: 17314195
-
Electrophysiologically-identified serotonin receptors in the rat CNS. Effect of antidepressant treatment.Neuropharmacology. 1984 Dec;23(12B):1511-20. doi: 10.1016/0028-3908(84)90095-9. Neuropharmacology. 1984. PMID: 6396527 Review. No abstract available.
Cited by
-
The interplay of serotonin 5-HT1A and 5-HT7 receptors in chronic stress.J Cell Sci. 2024 Oct 1;137(19):jcs262219. doi: 10.1242/jcs.262219. Epub 2024 Oct 11. J Cell Sci. 2024. PMID: 39279505 Free PMC article.
-
The 5-HT7 receptor system as a treatment target for mood and anxiety disorders: A systematic review.J Psychopharmacol. 2023 Dec;37(12):1167-1181. doi: 10.1177/02698811231211228. Epub 2023 Nov 23. J Psychopharmacol. 2023. PMID: 37994803 Free PMC article. Review.
-
Potential Anti-Amnesic Activity of a Novel Multimodal Derivative of Salicylamide, JJGW08, in Mice.Pharmaceuticals (Basel). 2023 Mar 6;16(3):399. doi: 10.3390/ph16030399. Pharmaceuticals (Basel). 2023. PMID: 36986498 Free PMC article.
-
Therapeutic Potential and Limitation of Serotonin Type 7 Receptor Modulation.Int J Mol Sci. 2023 Jan 20;24(3):2070. doi: 10.3390/ijms24032070. Int J Mol Sci. 2023. PMID: 36768393 Free PMC article. Review.
-
Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases.Mol Med. 2022 Jun 20;28(1):70. doi: 10.1186/s10020-022-00497-2. Mol Med. 2022. PMID: 35725396 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
