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Link to original content: http://pubmed.ncbi.nlm.nih.gov/16311631
An update on bioactive plant lignans - PubMed Skip to main page content
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Review
. 2005 Dec;22(6):696-716.
doi: 10.1039/b514045p. Epub 2005 Nov 2.

An update on bioactive plant lignans

Muhammad Saleem  1 , Hyoung Ja Kim, Muhammad Shaiq Ali, Yong Sup Lee
Affiliations
Review

An update on bioactive plant lignans

Muhammad Saleem et al. Nat Prod Rep. 2005 Dec.

Abstract

Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C6-C3) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives due to applications in cancer chemotherapy and various other pharmacological effects. This review deals with lignans possessing anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities, and comprises the data reported in more than 100 peer-reviewed articles, so as to highlight the recently reported bioactive lignans that could be a first step towards the development of potential new therapeutic agents.

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