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Link to original content: http://pubmed.ncbi.nlm.nih.gov/15366830
Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation - PubMed Skip to main page content
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. 2004 Sep 22;52(19):5843-8.
doi: 10.1021/jf040114k.

Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation

Kohei Kamiya  1 , Yohei Tanaka, Hanani Endang, Mansur Umar, Toshiko Satake
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Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation

Kohei Kamiya et al. J Agric Food Chem. .

Abstract

The oxidative modification of low-density lipoprotein (LDL) plays an important role in the genesis of arteriosclerosis. The present study focused on the effects of the fruits of Morinda citrifolia on preventing arteriosclerosis. The MeOH extract and CHCl(3)-, EtOAc-, n-BuOH-, and H(2)O-soluble phases derived from the fruits of M. citrifolia were evaluated for their inhibitory activity on copper-induced LDL oxidation by the thiobarbituric acid-reactive substances (TBARS) method. The MeOH extract and EtOAc-soluble phase showed 88 and 96% inhibition, respectively. Six lignans were isolated by repeated column chromatography from the EtOAc-soluble phase. These compounds were determined by spectroscopic analysis to be 3,3'-bisdemethylpinoresinol (1), americanol A (2), americanin A (3), americanoic acid A (4), morindolin (5), and isoprincepin (6), of which 4 and 5 are novel compounds. These compounds inhibited copper-induced LDL oxidation in a dose-dependent manner. 1, 2, 5, and 6 exhibited remarkably strong activities, which were the same or better than that of the known antioxidant 2,6-di-tert-butyl-p-cresol. The IC(50) values for 1, 2, 5, and 6 were 1.057, 2.447, 2.020, and 1.362 microM, respectively. The activity of these compounds is mainly due to their number of phenolic hydroxyl groups.

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